Overview of protein posttranslational modifications in Arthropoda venoms
Abstract Accidents with venomous animals are a public health issue worldwide. Among the species involved in these accidents are scorpions, spiders, bees, wasps, and other members of the phylum Arthropoda. The knowledge of the function of proteins present in these venoms is important to guide diagnos...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:053aa4543ea843f79ecd713d20ef54df 2023-05-15T15:12:11+02:00 Overview of protein posttranslational modifications in Arthropoda venoms Marcella Nunes de Melo-Braga Raniele da Silva Moreira João Henrique Diniz Brandão Gervásio Liza Figueiredo Felicori 2022-04-01T00:00:00Z https://doi.org/10.1590/1678-9199-jvatitd-2021-0047 https://doaj.org/article/053aa4543ea843f79ecd713d20ef54df EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992022000100202&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2021-0047 https://doaj.org/article/053aa4543ea843f79ecd713d20ef54df Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 28 (2022) Arthropod venom Posttranslational modification Glycosylation Phosphorylation PTM-venomics Mass spectrometry-based proteomics PTM-functional-venomics UniProtKB/Swiss-Prot database Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2022 ftdoajarticles https://doi.org/10.1590/1678-9199-jvatitd-2021-0047 2022-12-31T03:27:22Z Abstract Accidents with venomous animals are a public health issue worldwide. Among the species involved in these accidents are scorpions, spiders, bees, wasps, and other members of the phylum Arthropoda. The knowledge of the function of proteins present in these venoms is important to guide diagnosis, therapeutics, besides being a source of a large variety of biotechnological active molecules. Although our understanding about the characteristics and function of arthropod venoms has been evolving in the last decades, a major aspect crucial for the function of these proteins remains poorly studied, the posttranslational modifications (PTMs). Comprehension of such modifications can contribute to better understanding the basis of envenomation, leading to improvements in the specificities of potential therapeutic toxins. Therefore, in this review, we bring to light protein/toxin PTMs in arthropod venoms by accessing the information present in the UniProtKB/Swiss-Prot database, including experimental and putative inferences. Then, we concentrate our discussion on the current knowledge on protein phosphorylation and glycosylation, highlighting the potential functionality of these modifications in arthropod venom. We also briefly describe general approaches to study “PTM-functional-venomics”, herein referred to the integration of PTM-venomics with a functional investigation of PTM impact on venom biology. Furthermore, we discuss the bottlenecks in toxinology studies covering PTM investigation. In conclusion, through the mining of PTMs in arthropod venoms, we observed a large gap in this field that limits our understanding on the biology of these venoms, affecting the diagnosis and therapeutics development. Hence, we encourage community efforts to draw attention to a better understanding of PTM in arthropod venom toxins. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 28 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arthropod venom Posttranslational modification Glycosylation Phosphorylation PTM-venomics Mass spectrometry-based proteomics PTM-functional-venomics UniProtKB/Swiss-Prot database Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Arthropod venom Posttranslational modification Glycosylation Phosphorylation PTM-venomics Mass spectrometry-based proteomics PTM-functional-venomics UniProtKB/Swiss-Prot database Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Marcella Nunes de Melo-Braga Raniele da Silva Moreira João Henrique Diniz Brandão Gervásio Liza Figueiredo Felicori Overview of protein posttranslational modifications in Arthropoda venoms |
topic_facet |
Arthropod venom Posttranslational modification Glycosylation Phosphorylation PTM-venomics Mass spectrometry-based proteomics PTM-functional-venomics UniProtKB/Swiss-Prot database Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract Accidents with venomous animals are a public health issue worldwide. Among the species involved in these accidents are scorpions, spiders, bees, wasps, and other members of the phylum Arthropoda. The knowledge of the function of proteins present in these venoms is important to guide diagnosis, therapeutics, besides being a source of a large variety of biotechnological active molecules. Although our understanding about the characteristics and function of arthropod venoms has been evolving in the last decades, a major aspect crucial for the function of these proteins remains poorly studied, the posttranslational modifications (PTMs). Comprehension of such modifications can contribute to better understanding the basis of envenomation, leading to improvements in the specificities of potential therapeutic toxins. Therefore, in this review, we bring to light protein/toxin PTMs in arthropod venoms by accessing the information present in the UniProtKB/Swiss-Prot database, including experimental and putative inferences. Then, we concentrate our discussion on the current knowledge on protein phosphorylation and glycosylation, highlighting the potential functionality of these modifications in arthropod venom. We also briefly describe general approaches to study “PTM-functional-venomics”, herein referred to the integration of PTM-venomics with a functional investigation of PTM impact on venom biology. Furthermore, we discuss the bottlenecks in toxinology studies covering PTM investigation. In conclusion, through the mining of PTMs in arthropod venoms, we observed a large gap in this field that limits our understanding on the biology of these venoms, affecting the diagnosis and therapeutics development. Hence, we encourage community efforts to draw attention to a better understanding of PTM in arthropod venom toxins. |
format |
Article in Journal/Newspaper |
author |
Marcella Nunes de Melo-Braga Raniele da Silva Moreira João Henrique Diniz Brandão Gervásio Liza Figueiredo Felicori |
author_facet |
Marcella Nunes de Melo-Braga Raniele da Silva Moreira João Henrique Diniz Brandão Gervásio Liza Figueiredo Felicori |
author_sort |
Marcella Nunes de Melo-Braga |
title |
Overview of protein posttranslational modifications in Arthropoda venoms |
title_short |
Overview of protein posttranslational modifications in Arthropoda venoms |
title_full |
Overview of protein posttranslational modifications in Arthropoda venoms |
title_fullStr |
Overview of protein posttranslational modifications in Arthropoda venoms |
title_full_unstemmed |
Overview of protein posttranslational modifications in Arthropoda venoms |
title_sort |
overview of protein posttranslational modifications in arthropoda venoms |
publisher |
SciELO |
publishDate |
2022 |
url |
https://doi.org/10.1590/1678-9199-jvatitd-2021-0047 https://doaj.org/article/053aa4543ea843f79ecd713d20ef54df |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 28 (2022) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992022000100202&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2021-0047 https://doaj.org/article/053aa4543ea843f79ecd713d20ef54df |
op_doi |
https://doi.org/10.1590/1678-9199-jvatitd-2021-0047 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
28 |
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