Post-treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia
Abstract Parenteral artesunate has been shown to be a superior treatment option compared to parenteral quinine in adults and children with severe malaria. Little evidence, however, is available on long-term safety. Recently, cases of late-onset haemolysis after parenteral treatment with artesunate h...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2012
|
Subjects: | |
Online Access: | https://doi.org/10.1186/1475-2875-11-169 https://doaj.org/article/052284e943a843d88e8c84d2f5832b3a |
id |
ftdoajarticles:oai:doaj.org/article:052284e943a843d88e8c84d2f5832b3a |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:052284e943a843d88e8c84d2f5832b3a 2023-05-15T15:07:36+02:00 Post-treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia Rolling Thierry Schmiedel Stefan Wichmann Dominic Wittkopf Dieter Burchard Gerd-Dieter Cramer Jakob P 2012-05-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-169 https://doaj.org/article/052284e943a843d88e8c84d2f5832b3a EN eng BMC http://www.malariajournal.com/content/11/1/169 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-169 1475-2875 https://doaj.org/article/052284e943a843d88e8c84d2f5832b3a Malaria Journal, Vol 11, Iss 1, p 169 (2012) Severe imported malaria Artesunate Haemolysis Reticulocytes Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-169 2022-12-31T09:14:41Z Abstract Parenteral artesunate has been shown to be a superior treatment option compared to parenteral quinine in adults and children with severe malaria. Little evidence, however, is available on long-term safety. Recently, cases of late-onset haemolysis after parenteral treatment with artesunate have been reported in European travellers with imported Plasmodium falciparum malaria. Therefore, an extended follow-up of adult patients treated for severe imported malaria was started in August 2011 at the University Medical Center Hamburg-Eppendorf. Until January 2012, three patients with hyperparasitaemia (range: 14-21%) were included for analysis. In all three patients, delayed haemolysis was detected in the second week after the first dose of intravenous artesunate. Reticulocyte production index remained inadequately low in the 7 – 14 days following the first dose of artesunate despite rapid parasite clearance. Post-treatment haemolysis after parenteral artesunate may be of clinical relevance in particular in imported severe malaria characterized by high parasite levels. Extended follow-up of at least 30 days including controls of haematological parameters after artesunate treatment seems to be indicated. Further investigations are needed to assess frequency and pathophysiological background of this complication. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Severe imported malaria Artesunate Haemolysis Reticulocytes Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Severe imported malaria Artesunate Haemolysis Reticulocytes Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Rolling Thierry Schmiedel Stefan Wichmann Dominic Wittkopf Dieter Burchard Gerd-Dieter Cramer Jakob P Post-treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia |
topic_facet |
Severe imported malaria Artesunate Haemolysis Reticulocytes Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Parenteral artesunate has been shown to be a superior treatment option compared to parenteral quinine in adults and children with severe malaria. Little evidence, however, is available on long-term safety. Recently, cases of late-onset haemolysis after parenteral treatment with artesunate have been reported in European travellers with imported Plasmodium falciparum malaria. Therefore, an extended follow-up of adult patients treated for severe imported malaria was started in August 2011 at the University Medical Center Hamburg-Eppendorf. Until January 2012, three patients with hyperparasitaemia (range: 14-21%) were included for analysis. In all three patients, delayed haemolysis was detected in the second week after the first dose of intravenous artesunate. Reticulocyte production index remained inadequately low in the 7 – 14 days following the first dose of artesunate despite rapid parasite clearance. Post-treatment haemolysis after parenteral artesunate may be of clinical relevance in particular in imported severe malaria characterized by high parasite levels. Extended follow-up of at least 30 days including controls of haematological parameters after artesunate treatment seems to be indicated. Further investigations are needed to assess frequency and pathophysiological background of this complication. |
format |
Article in Journal/Newspaper |
author |
Rolling Thierry Schmiedel Stefan Wichmann Dominic Wittkopf Dieter Burchard Gerd-Dieter Cramer Jakob P |
author_facet |
Rolling Thierry Schmiedel Stefan Wichmann Dominic Wittkopf Dieter Burchard Gerd-Dieter Cramer Jakob P |
author_sort |
Rolling Thierry |
title |
Post-treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia |
title_short |
Post-treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia |
title_full |
Post-treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia |
title_fullStr |
Post-treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia |
title_full_unstemmed |
Post-treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia |
title_sort |
post-treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-169 https://doaj.org/article/052284e943a843d88e8c84d2f5832b3a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 169 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/169 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-169 1475-2875 https://doaj.org/article/052284e943a843d88e8c84d2f5832b3a |
op_doi |
https://doi.org/10.1186/1475-2875-11-169 |
container_title |
Malaria Journal |
container_volume |
11 |
container_issue |
1 |
_version_ |
1766339066640465920 |