Acute kidney failure following severe viper envenomation: clinical, biological and ultrasonographic aspects
Abstract Background: Acute kidney injury (AKI) is a frequent complication of snakebite envenomation, which is still little known in sub-Saharan Africa. This study aims to describe the clinical, biological and ultrasonographic aspects of AKI following severe snakebite envenomation managed in the inte...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:0514210ad1694e1c83d9e521bcc57db0 2023-05-15T15:15:41+02:00 Acute kidney failure following severe viper envenomation: clinical, biological and ultrasonographic aspects Blaise Adelin Tchaou Kofi-Mensa Savi de Tové Charles Frédéric Tchégnonsi N’Vènonfon Patrick Kouomboua Mfin Abdou-Rahman Aguemon Martin Chobli Jean-Philippe Chippaux https://doi.org/10.1590/1678-9199-jvatitd-2020-0059 https://doaj.org/article/0514210ad1694e1c83d9e521bcc57db0 EN eng SciELO http://www.scielo.br/pdf/jvatitd/v26/1678-9199-jvatitd-26-e20200059.pdf http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992020000100340&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2020-0059 https://doaj.org/article/0514210ad1694e1c83d9e521bcc57db0 Journal of Venomous Animals and Toxins including Tropical Diseases Envenomation Snakebite Antivenom Acute kidney injury KDIGO Subcapsular hematoma Hemorrhagic syndrome Benin Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article ftdoajarticles https://doi.org/10.1590/1678-9199-jvatitd-2020-0059 2022-12-31T14:37:26Z Abstract Background: Acute kidney injury (AKI) is a frequent complication of snakebite envenomation, which is still little known in sub-Saharan Africa. This study aims to describe the clinical, biological and ultrasonographic aspects of AKI following severe snakebite envenomation managed in the intensive care unit. Method: A prospective observational survey was performed in Benin over a period of 18 months. All patients suffering severe snakebite envenomation (SBE) were included. The diagnosis of AKI was made using the KDIGO criteria. Kidney ultrasound exam was performed in all patients to assess internal bleeding and morphological and structural abnormalities of the kidneys. Results: Fifty-one cases of severe SBE were included. All patients presented inflammatory syndrome and showed abnormal WBCT whereas bleeding was found in 46 of them (90%). The median time to hospital presentation was three days. The majority of patients were male (M/F sex ratio = 1.55) and the median age was 26. Sixteen patients (31%) showed AKI according to the KDIGO criteria. Severe AKI (KDIGO stage 2 and 3) was observed in three patients, including one stage 2 and two stage 3. Kidney ultrasound revealed three cases of kidney capsular hematoma (6%), two cases of kidney hypertrophy (3%), three cases of kidney injury (4%), two stage 1 KDIGO and one stage 2 KDIGO. Only one patient benefited from hemodialysis. All patients showing AKI recovered without sequels. The median duration of hospital stays was four days. Seven patients died (14%) including four among the 16 AKI patients. Antivenom has been administered to 41 patients (80%). The comparison between patients without and with AKI did not show any significant difference except gender (p = 10-2). Conclusion: AKI is a common complication of severe snakebite envenomation. Resulting from inflammatory and hemorrhagic disorders, AKI may prove to be a short-term life-threatening factor. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Envenomation Snakebite Antivenom Acute kidney injury KDIGO Subcapsular hematoma Hemorrhagic syndrome Benin Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Envenomation Snakebite Antivenom Acute kidney injury KDIGO Subcapsular hematoma Hemorrhagic syndrome Benin Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Blaise Adelin Tchaou Kofi-Mensa Savi de Tové Charles Frédéric Tchégnonsi N’Vènonfon Patrick Kouomboua Mfin Abdou-Rahman Aguemon Martin Chobli Jean-Philippe Chippaux Acute kidney failure following severe viper envenomation: clinical, biological and ultrasonographic aspects |
topic_facet |
Envenomation Snakebite Antivenom Acute kidney injury KDIGO Subcapsular hematoma Hemorrhagic syndrome Benin Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract Background: Acute kidney injury (AKI) is a frequent complication of snakebite envenomation, which is still little known in sub-Saharan Africa. This study aims to describe the clinical, biological and ultrasonographic aspects of AKI following severe snakebite envenomation managed in the intensive care unit. Method: A prospective observational survey was performed in Benin over a period of 18 months. All patients suffering severe snakebite envenomation (SBE) were included. The diagnosis of AKI was made using the KDIGO criteria. Kidney ultrasound exam was performed in all patients to assess internal bleeding and morphological and structural abnormalities of the kidneys. Results: Fifty-one cases of severe SBE were included. All patients presented inflammatory syndrome and showed abnormal WBCT whereas bleeding was found in 46 of them (90%). The median time to hospital presentation was three days. The majority of patients were male (M/F sex ratio = 1.55) and the median age was 26. Sixteen patients (31%) showed AKI according to the KDIGO criteria. Severe AKI (KDIGO stage 2 and 3) was observed in three patients, including one stage 2 and two stage 3. Kidney ultrasound revealed three cases of kidney capsular hematoma (6%), two cases of kidney hypertrophy (3%), three cases of kidney injury (4%), two stage 1 KDIGO and one stage 2 KDIGO. Only one patient benefited from hemodialysis. All patients showing AKI recovered without sequels. The median duration of hospital stays was four days. Seven patients died (14%) including four among the 16 AKI patients. Antivenom has been administered to 41 patients (80%). The comparison between patients without and with AKI did not show any significant difference except gender (p = 10-2). Conclusion: AKI is a common complication of severe snakebite envenomation. Resulting from inflammatory and hemorrhagic disorders, AKI may prove to be a short-term life-threatening factor. |
format |
Article in Journal/Newspaper |
author |
Blaise Adelin Tchaou Kofi-Mensa Savi de Tové Charles Frédéric Tchégnonsi N’Vènonfon Patrick Kouomboua Mfin Abdou-Rahman Aguemon Martin Chobli Jean-Philippe Chippaux |
author_facet |
Blaise Adelin Tchaou Kofi-Mensa Savi de Tové Charles Frédéric Tchégnonsi N’Vènonfon Patrick Kouomboua Mfin Abdou-Rahman Aguemon Martin Chobli Jean-Philippe Chippaux |
author_sort |
Blaise Adelin Tchaou |
title |
Acute kidney failure following severe viper envenomation: clinical, biological and ultrasonographic aspects |
title_short |
Acute kidney failure following severe viper envenomation: clinical, biological and ultrasonographic aspects |
title_full |
Acute kidney failure following severe viper envenomation: clinical, biological and ultrasonographic aspects |
title_fullStr |
Acute kidney failure following severe viper envenomation: clinical, biological and ultrasonographic aspects |
title_full_unstemmed |
Acute kidney failure following severe viper envenomation: clinical, biological and ultrasonographic aspects |
title_sort |
acute kidney failure following severe viper envenomation: clinical, biological and ultrasonographic aspects |
publisher |
SciELO |
url |
https://doi.org/10.1590/1678-9199-jvatitd-2020-0059 https://doaj.org/article/0514210ad1694e1c83d9e521bcc57db0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases |
op_relation |
http://www.scielo.br/pdf/jvatitd/v26/1678-9199-jvatitd-26-e20200059.pdf http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992020000100340&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2020-0059 https://doaj.org/article/0514210ad1694e1c83d9e521bcc57db0 |
op_doi |
https://doi.org/10.1590/1678-9199-jvatitd-2020-0059 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
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