Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017.
Dengue fever, a mosquito-borne viral disease in humans, has been endemic in many Southeast Asian countries. Since its first outbreak in 1978 in Foshan, Guangdong province, China, dengue has been continually epidemic in recent years in Guangdong, which raised the concern whether dengue infection is e...
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ftdoajarticles:oai:doaj.org/article:04c39b81d85b4fd79e412a960d57ec1c 2023-05-15T15:09:02+02:00 Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017. Bangyao Sun Xin Zhang Huan Zhang Haizhou Liu Lina Sun Qiqi Tan Mifang Liang De Wu Di Liu 2020-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008049 https://doaj.org/article/04c39b81d85b4fd79e412a960d57ec1c EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008049 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008049 https://doaj.org/article/04c39b81d85b4fd79e412a960d57ec1c PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008049 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008049 2022-12-31T13:53:10Z Dengue fever, a mosquito-borne viral disease in humans, has been endemic in many Southeast Asian countries. Since its first outbreak in 1978 in Foshan, Guangdong province, China, dengue has been continually epidemic in recent years in Guangdong, which raised the concern whether dengue infection is endemic in Guangdong. In this study, we performed phylogenetic, recombinant, and nucleotide variation analyses of 114 complete genome sequences of dengue virus serotypes 1-4 (DENV1-4) collected from 2013 to 2017 in 18 of 21 cities of Guangdong. Phylogenetic analyses revealed that DENV sequences did not form a single cluster, indicating that dengue fever was not endemic in Guangdong, although DENV1-4 co-circulated in Guangdong. Twenty intra-serotype recombinant isolates involving DENV1-4 were detected, but no inter-serotype recombinant events were identified in this study. Additionally, the most recombinant events were detected simultaneously in the gene NS3 of DENV1-4. Nucleotide variation analyses showed that no significant intra-serotype differences were observed, whereas more significant inter-subtype differences were discovered in non-structural genes than in structural genes. Our investigation will facilitate the understanding of the current prevalent status of dengue fever in Guangdong and contribute to designing more effective preventive and control strategies for dengue infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 3 e0008049 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Bangyao Sun Xin Zhang Huan Zhang Haizhou Liu Lina Sun Qiqi Tan Mifang Liang De Wu Di Liu Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Dengue fever, a mosquito-borne viral disease in humans, has been endemic in many Southeast Asian countries. Since its first outbreak in 1978 in Foshan, Guangdong province, China, dengue has been continually epidemic in recent years in Guangdong, which raised the concern whether dengue infection is endemic in Guangdong. In this study, we performed phylogenetic, recombinant, and nucleotide variation analyses of 114 complete genome sequences of dengue virus serotypes 1-4 (DENV1-4) collected from 2013 to 2017 in 18 of 21 cities of Guangdong. Phylogenetic analyses revealed that DENV sequences did not form a single cluster, indicating that dengue fever was not endemic in Guangdong, although DENV1-4 co-circulated in Guangdong. Twenty intra-serotype recombinant isolates involving DENV1-4 were detected, but no inter-serotype recombinant events were identified in this study. Additionally, the most recombinant events were detected simultaneously in the gene NS3 of DENV1-4. Nucleotide variation analyses showed that no significant intra-serotype differences were observed, whereas more significant inter-subtype differences were discovered in non-structural genes than in structural genes. Our investigation will facilitate the understanding of the current prevalent status of dengue fever in Guangdong and contribute to designing more effective preventive and control strategies for dengue infection. |
format |
Article in Journal/Newspaper |
author |
Bangyao Sun Xin Zhang Huan Zhang Haizhou Liu Lina Sun Qiqi Tan Mifang Liang De Wu Di Liu |
author_facet |
Bangyao Sun Xin Zhang Huan Zhang Haizhou Liu Lina Sun Qiqi Tan Mifang Liang De Wu Di Liu |
author_sort |
Bangyao Sun |
title |
Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017. |
title_short |
Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017. |
title_full |
Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017. |
title_fullStr |
Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017. |
title_full_unstemmed |
Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017. |
title_sort |
genomic epidemiological characteristics of dengue fever in guangdong province, china from 2013 to 2017. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008049 https://doaj.org/article/04c39b81d85b4fd79e412a960d57ec1c |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008049 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008049 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008049 https://doaj.org/article/04c39b81d85b4fd79e412a960d57ec1c |
op_doi |
https://doi.org/10.1371/journal.pntd.0008049 |
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PLOS Neglected Tropical Diseases |
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14 |
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3 |
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e0008049 |
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