Opportunity cost for early treatment of Chagas disease in Mexico.
BACKGROUND: Given current neglect for Chagas disease in public health programs in Mexico, future healthcare and economic development policies will need a more robust model to analyze costs and impacts of timely clinical attention of infected populations. METHODOLOGY/PRINCIPAL FINDINGS: A Markov deci...
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ftdoajarticles:oai:doaj.org/article:04b06760774640b0883be5352d166e75 2023-05-15T15:08:05+02:00 Opportunity cost for early treatment of Chagas disease in Mexico. Janine M Ramsey Miguel Elizondo-Cano Gilberto Sanchez-González Adriana Peña-Nieves Alejandro Figueroa-Lara 2014-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002776 https://doaj.org/article/04b06760774640b0883be5352d166e75 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3990484?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002776 https://doaj.org/article/04b06760774640b0883be5352d166e75 PLoS Neglected Tropical Diseases, Vol 8, Iss 4, p e2776 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002776 2022-12-31T14:11:46Z BACKGROUND: Given current neglect for Chagas disease in public health programs in Mexico, future healthcare and economic development policies will need a more robust model to analyze costs and impacts of timely clinical attention of infected populations. METHODOLOGY/PRINCIPAL FINDINGS: A Markov decision model was constructed to simulate the natural history of a Chagas disease cohort in Mexico and to project the associated short and long-term clinical outcomes and corresponding costs. The lifetime cost for a timely diagnosed and treated Chagas disease patient is US$ 10,160, while the cost for an undiagnosed individual is US$ 11,877. The cost of a diagnosed and treated case increases 24-fold from early acute to indeterminate stage. The major cost component for lifetime cost was working days lost, between 44% and 75%, depending on the program scenario for timely diagnosis and treatment. CONCLUSIONS/SIGNIFICANCE: In the long term, it is cheaper to diagnose and treat chagasic patients early, instead of doing nothing. This finding by itself argues for the need to shift current policy, in order to prioritize and attend this neglected disease for the benefit of social and economic development, which implies including treatment drugs in the national formularies. Present results are even more relevant, if one considers that timely diagnosis and treatment can arrest clinical progression and enhance a chronic patient's quality of life. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 4 e2776 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Janine M Ramsey Miguel Elizondo-Cano Gilberto Sanchez-González Adriana Peña-Nieves Alejandro Figueroa-Lara Opportunity cost for early treatment of Chagas disease in Mexico. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Given current neglect for Chagas disease in public health programs in Mexico, future healthcare and economic development policies will need a more robust model to analyze costs and impacts of timely clinical attention of infected populations. METHODOLOGY/PRINCIPAL FINDINGS: A Markov decision model was constructed to simulate the natural history of a Chagas disease cohort in Mexico and to project the associated short and long-term clinical outcomes and corresponding costs. The lifetime cost for a timely diagnosed and treated Chagas disease patient is US$ 10,160, while the cost for an undiagnosed individual is US$ 11,877. The cost of a diagnosed and treated case increases 24-fold from early acute to indeterminate stage. The major cost component for lifetime cost was working days lost, between 44% and 75%, depending on the program scenario for timely diagnosis and treatment. CONCLUSIONS/SIGNIFICANCE: In the long term, it is cheaper to diagnose and treat chagasic patients early, instead of doing nothing. This finding by itself argues for the need to shift current policy, in order to prioritize and attend this neglected disease for the benefit of social and economic development, which implies including treatment drugs in the national formularies. Present results are even more relevant, if one considers that timely diagnosis and treatment can arrest clinical progression and enhance a chronic patient's quality of life. |
format |
Article in Journal/Newspaper |
author |
Janine M Ramsey Miguel Elizondo-Cano Gilberto Sanchez-González Adriana Peña-Nieves Alejandro Figueroa-Lara |
author_facet |
Janine M Ramsey Miguel Elizondo-Cano Gilberto Sanchez-González Adriana Peña-Nieves Alejandro Figueroa-Lara |
author_sort |
Janine M Ramsey |
title |
Opportunity cost for early treatment of Chagas disease in Mexico. |
title_short |
Opportunity cost for early treatment of Chagas disease in Mexico. |
title_full |
Opportunity cost for early treatment of Chagas disease in Mexico. |
title_fullStr |
Opportunity cost for early treatment of Chagas disease in Mexico. |
title_full_unstemmed |
Opportunity cost for early treatment of Chagas disease in Mexico. |
title_sort |
opportunity cost for early treatment of chagas disease in mexico. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0002776 https://doaj.org/article/04b06760774640b0883be5352d166e75 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 4, p e2776 (2014) |
op_relation |
http://europepmc.org/articles/PMC3990484?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002776 https://doaj.org/article/04b06760774640b0883be5352d166e75 |
op_doi |
https://doi.org/10.1371/journal.pntd.0002776 |
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PLoS Neglected Tropical Diseases |
container_volume |
8 |
container_issue |
4 |
container_start_page |
e2776 |
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1766339513772146688 |