Assessment of false negative rates of lactate dehydrogenase-based malaria rapid diagnostic tests for Plasmodium ovale detection.
Currently, malaria rapid diagnostic tests (RDTs) are widely used for malaria diagnosis, but test performance and the factors that lead to failure of Plasmodium ovale detection are not well understood. In this study, three pLDH-based RDTs were evaluated using cases in China that originated in Africa....
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ftdoajarticles:oai:doaj.org/article:0447582609d945b88f976091c2e33285 2023-05-15T15:05:37+02:00 Assessment of false negative rates of lactate dehydrogenase-based malaria rapid diagnostic tests for Plasmodium ovale detection. Jianxia Tang Feng Tang Hongru Zhu Feng Lu Sui Xu Yuanyuan Cao Yaping Gu Xiaoqin He Huayun Zhou Guoding Zhu Jun Cao 2019-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007254 https://doaj.org/article/0447582609d945b88f976091c2e33285 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007254 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007254 https://doaj.org/article/0447582609d945b88f976091c2e33285 PLoS Neglected Tropical Diseases, Vol 13, Iss 3, p e0007254 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007254 2022-12-31T11:51:07Z Currently, malaria rapid diagnostic tests (RDTs) are widely used for malaria diagnosis, but test performance and the factors that lead to failure of Plasmodium ovale detection are not well understood. In this study, three pLDH-based RDTs were evaluated using cases in China that originated in Africa. The sensitivity of Wondfo Pf/Pan, CareStart pLDH PAN and SD BIOLINE Pf/Pan in P. ovale detection was 70, 55 and 18%, respectively. CareStart was worse at detecting P. o. curtisi (36.5%) than at detecting P. o. wallikeri (75.0%), and SD could not detect P. o. curtisi. The overall detection ratio of all three RDTs decreased with parasite density and pLDH concentration. Wondfo, CareStart and SD detected only 75.0, 78.1 and 46.9% of the P. ovale cases, respectively, even when the parasitemia were higher than 5000 parasites/μL. Subspecies of P. ovale should be considered while to improve RDT quality for P. ovale diagnosis to achieve the goal of malaria elimination. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 3 e0007254 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jianxia Tang Feng Tang Hongru Zhu Feng Lu Sui Xu Yuanyuan Cao Yaping Gu Xiaoqin He Huayun Zhou Guoding Zhu Jun Cao Assessment of false negative rates of lactate dehydrogenase-based malaria rapid diagnostic tests for Plasmodium ovale detection. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Currently, malaria rapid diagnostic tests (RDTs) are widely used for malaria diagnosis, but test performance and the factors that lead to failure of Plasmodium ovale detection are not well understood. In this study, three pLDH-based RDTs were evaluated using cases in China that originated in Africa. The sensitivity of Wondfo Pf/Pan, CareStart pLDH PAN and SD BIOLINE Pf/Pan in P. ovale detection was 70, 55 and 18%, respectively. CareStart was worse at detecting P. o. curtisi (36.5%) than at detecting P. o. wallikeri (75.0%), and SD could not detect P. o. curtisi. The overall detection ratio of all three RDTs decreased with parasite density and pLDH concentration. Wondfo, CareStart and SD detected only 75.0, 78.1 and 46.9% of the P. ovale cases, respectively, even when the parasitemia were higher than 5000 parasites/μL. Subspecies of P. ovale should be considered while to improve RDT quality for P. ovale diagnosis to achieve the goal of malaria elimination. |
format |
Article in Journal/Newspaper |
author |
Jianxia Tang Feng Tang Hongru Zhu Feng Lu Sui Xu Yuanyuan Cao Yaping Gu Xiaoqin He Huayun Zhou Guoding Zhu Jun Cao |
author_facet |
Jianxia Tang Feng Tang Hongru Zhu Feng Lu Sui Xu Yuanyuan Cao Yaping Gu Xiaoqin He Huayun Zhou Guoding Zhu Jun Cao |
author_sort |
Jianxia Tang |
title |
Assessment of false negative rates of lactate dehydrogenase-based malaria rapid diagnostic tests for Plasmodium ovale detection. |
title_short |
Assessment of false negative rates of lactate dehydrogenase-based malaria rapid diagnostic tests for Plasmodium ovale detection. |
title_full |
Assessment of false negative rates of lactate dehydrogenase-based malaria rapid diagnostic tests for Plasmodium ovale detection. |
title_fullStr |
Assessment of false negative rates of lactate dehydrogenase-based malaria rapid diagnostic tests for Plasmodium ovale detection. |
title_full_unstemmed |
Assessment of false negative rates of lactate dehydrogenase-based malaria rapid diagnostic tests for Plasmodium ovale detection. |
title_sort |
assessment of false negative rates of lactate dehydrogenase-based malaria rapid diagnostic tests for plasmodium ovale detection. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007254 https://doaj.org/article/0447582609d945b88f976091c2e33285 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 3, p e0007254 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007254 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007254 https://doaj.org/article/0447582609d945b88f976091c2e33285 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007254 |
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PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
3 |
container_start_page |
e0007254 |
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1766337283309436928 |