Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo

Abstract Background Malaria morbidity and mortality increase in the Democratic Republic of the Congo (DRC) may be the consequence of the low utilization rate of long-lasting insecticidal nets (LLINs) resulting from poor compliance due to adverse events (AEs). This study aimed at determining the prev...

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Published in:Malaria Journal
Main Authors: Gillon Ilombe, Thérèse Mpiempie, Gauthier Mesia, Junior R. Matangila, Aimée M. Lulebo, Vivi Maketa, Baby Mabanzila, Nicole M. Muela, Flory T. Muanda, Sylvie Linsuke, Jean-Pierre van Geertruyden, Pascal Lutumba
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2023
Subjects:
Online Access:https://doi.org/10.1186/s12936-023-04458-w
https://doaj.org/article/04265a0605774c4798b72ede4a52837e
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spelling ftdoajarticles:oai:doaj.org/article:04265a0605774c4798b72ede4a52837e 2023-05-15T15:15:44+02:00 Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo Gillon Ilombe Thérèse Mpiempie Gauthier Mesia Junior R. Matangila Aimée M. Lulebo Vivi Maketa Baby Mabanzila Nicole M. Muela Flory T. Muanda Sylvie Linsuke Jean-Pierre van Geertruyden Pascal Lutumba 2023-02-01T00:00:00Z https://doi.org/10.1186/s12936-023-04458-w https://doaj.org/article/04265a0605774c4798b72ede4a52837e EN eng BMC https://doi.org/10.1186/s12936-023-04458-w https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04458-w 1475-2875 https://doaj.org/article/04265a0605774c4798b72ede4a52837e Malaria Journal, Vol 22, Iss 1, Pp 1-8 (2023) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1186/s12936-023-04458-w 2023-02-12T01:32:43Z Abstract Background Malaria morbidity and mortality increase in the Democratic Republic of the Congo (DRC) may be the consequence of the low utilization rate of long-lasting insecticidal nets (LLINs) resulting from poor compliance due to adverse events (AEs). This study aimed at determining the prevalence and predictors of AEs following the mass distribution of LLINs in the Kisantu Health Zone (KHZ), a high malaria-endemic region in the DRC. Methods A community-based cross-sectional study embedded was conducted within a randomized controlled trial (RCT) after the mass distribution of LLINs in 30 villages located in DRC KHZ. A three-stage sampling method was used without replacement to select 1790 children. Data was collected on adverse events (AEs) using a reporting form and information on demographics, nutritional status, and house characteristics. This was done using a structured questionnaire administered to household heads. Logistic regression models were used to identify predictors of AEs following the mass distribution of LLINs. Result In a total of 1790 children enrolled, 17.8% (95% CI 16.1–19.7) experienced AEs. The most common AEs were respiratory-related (61%). Around 60% of AEs occurred within 24 h of use, and 51% were resolved without treatment. Sleeping under deltamethrin LLINs (Adjusted OR, 95% CI 5.5 [3.8–8.0]) and zinc roofing (Adjusted OR, 95% CI 1.98 [1.1–3.57]) were associated with the risk of reporting an AE following the mass distribution of LLINs. Conclusion Approximately 1 out of 5 children had an AE within 24 h following LLIN use. These adverse events were often respiratory-related. LLINs and roofing types were associated with a higher risk of reporting AEs. However, further research using a robust study design is needed to confirm these findings. Future studies should design and implement interventions aiming to reduce AEs and improve compliance with LLINs. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 22 1
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
spellingShingle Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Gillon Ilombe
Thérèse Mpiempie
Gauthier Mesia
Junior R. Matangila
Aimée M. Lulebo
Vivi Maketa
Baby Mabanzila
Nicole M. Muela
Flory T. Muanda
Sylvie Linsuke
Jean-Pierre van Geertruyden
Pascal Lutumba
Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo
topic_facet Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
description Abstract Background Malaria morbidity and mortality increase in the Democratic Republic of the Congo (DRC) may be the consequence of the low utilization rate of long-lasting insecticidal nets (LLINs) resulting from poor compliance due to adverse events (AEs). This study aimed at determining the prevalence and predictors of AEs following the mass distribution of LLINs in the Kisantu Health Zone (KHZ), a high malaria-endemic region in the DRC. Methods A community-based cross-sectional study embedded was conducted within a randomized controlled trial (RCT) after the mass distribution of LLINs in 30 villages located in DRC KHZ. A three-stage sampling method was used without replacement to select 1790 children. Data was collected on adverse events (AEs) using a reporting form and information on demographics, nutritional status, and house characteristics. This was done using a structured questionnaire administered to household heads. Logistic regression models were used to identify predictors of AEs following the mass distribution of LLINs. Result In a total of 1790 children enrolled, 17.8% (95% CI 16.1–19.7) experienced AEs. The most common AEs were respiratory-related (61%). Around 60% of AEs occurred within 24 h of use, and 51% were resolved without treatment. Sleeping under deltamethrin LLINs (Adjusted OR, 95% CI 5.5 [3.8–8.0]) and zinc roofing (Adjusted OR, 95% CI 1.98 [1.1–3.57]) were associated with the risk of reporting an AE following the mass distribution of LLINs. Conclusion Approximately 1 out of 5 children had an AE within 24 h following LLIN use. These adverse events were often respiratory-related. LLINs and roofing types were associated with a higher risk of reporting AEs. However, further research using a robust study design is needed to confirm these findings. Future studies should design and implement interventions aiming to reduce AEs and improve compliance with LLINs.
format Article in Journal/Newspaper
author Gillon Ilombe
Thérèse Mpiempie
Gauthier Mesia
Junior R. Matangila
Aimée M. Lulebo
Vivi Maketa
Baby Mabanzila
Nicole M. Muela
Flory T. Muanda
Sylvie Linsuke
Jean-Pierre van Geertruyden
Pascal Lutumba
author_facet Gillon Ilombe
Thérèse Mpiempie
Gauthier Mesia
Junior R. Matangila
Aimée M. Lulebo
Vivi Maketa
Baby Mabanzila
Nicole M. Muela
Flory T. Muanda
Sylvie Linsuke
Jean-Pierre van Geertruyden
Pascal Lutumba
author_sort Gillon Ilombe
title Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo
title_short Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo
title_full Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo
title_fullStr Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo
title_full_unstemmed Prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the Democratic Republic of the Congo
title_sort prevalence and predictors of adverse events following exposure to long-lasting insecticidal nets used for malaria prevention: a community based cross-sectional study in the democratic republic of the congo
publisher BMC
publishDate 2023
url https://doi.org/10.1186/s12936-023-04458-w
https://doaj.org/article/04265a0605774c4798b72ede4a52837e
geographic Arctic
geographic_facet Arctic
genre Arctic
genre_facet Arctic
op_source Malaria Journal, Vol 22, Iss 1, Pp 1-8 (2023)
op_relation https://doi.org/10.1186/s12936-023-04458-w
https://doaj.org/toc/1475-2875
doi:10.1186/s12936-023-04458-w
1475-2875
https://doaj.org/article/04265a0605774c4798b72ede4a52837e
op_doi https://doi.org/10.1186/s12936-023-04458-w
container_title Malaria Journal
container_volume 22
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