In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom
The available Razi Institute antivenom is still, empirically, used by intramuscular (IM) administration for the treatment of scorpion stings in humans by six medically dangerous species including Hemiscorpius lepturus (H. lepturus). The aim of this study was to assess the neutralizing ability and ef...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:041f958280a642e4bf43acd5228dfc7a 2023-05-15T15:05:56+02:00 In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom A Jalali M H Pipelzadeh R Seyedian A H Rahmani N Omidian 2011-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992011000200004 https://doaj.org/article/041f958280a642e4bf43acd5228dfc7a EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000200004 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992011000200004 1678-9199 https://doaj.org/article/041f958280a642e4bf43acd5228dfc7a Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 17, Iss 2, Pp 142-149 (2011) Hemiscorpius lepturus scorpion venom hemolysis antivenom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2011 ftdoajarticles https://doi.org/10.1590/S1678-91992011000200004 2022-12-31T14:11:04Z The available Razi Institute antivenom is still, empirically, used by intramuscular (IM) administration for the treatment of scorpion stings in humans by six medically dangerous species including Hemiscorpius lepturus (H. lepturus). The aim of this study was to assess the neutralizing ability and effectiveness of the antivenom in inhibiting hemoglobinuria, biochemical changes, increased microalbuminuria and urinary lactate dehydrogenase (LDH) following H. lepturus sting. Simultaneous intramuscular administration of 10 μL and 100 μL of antivenom, after 24 hours, had no significant preventive effect on the extent and degree of hemoglobinuria or proteinuria produced in venom-treated rats. After IM administration of antivenom, no significant changes in decreased red blood cell (RBC) count and hemoglobin were observed. Immediate intramuscular administration of 10 μL of antivenom had no significant effects on both LDH and microalbuminuria. The present findings did not present correlation with clinical signs. Therefore, to fully assess the efficacy of the available antivenom and make appropriate recommendations, more in vivo or in vitro investigations including antigen-antibody interaction, enzymatic analysis and route-dependent administration are required. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 17 2 142 149 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Hemiscorpius lepturus scorpion venom hemolysis antivenom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Hemiscorpius lepturus scorpion venom hemolysis antivenom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 A Jalali M H Pipelzadeh R Seyedian A H Rahmani N Omidian In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom |
topic_facet |
Hemiscorpius lepturus scorpion venom hemolysis antivenom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
The available Razi Institute antivenom is still, empirically, used by intramuscular (IM) administration for the treatment of scorpion stings in humans by six medically dangerous species including Hemiscorpius lepturus (H. lepturus). The aim of this study was to assess the neutralizing ability and effectiveness of the antivenom in inhibiting hemoglobinuria, biochemical changes, increased microalbuminuria and urinary lactate dehydrogenase (LDH) following H. lepturus sting. Simultaneous intramuscular administration of 10 μL and 100 μL of antivenom, after 24 hours, had no significant preventive effect on the extent and degree of hemoglobinuria or proteinuria produced in venom-treated rats. After IM administration of antivenom, no significant changes in decreased red blood cell (RBC) count and hemoglobin were observed. Immediate intramuscular administration of 10 μL of antivenom had no significant effects on both LDH and microalbuminuria. The present findings did not present correlation with clinical signs. Therefore, to fully assess the efficacy of the available antivenom and make appropriate recommendations, more in vivo or in vitro investigations including antigen-antibody interaction, enzymatic analysis and route-dependent administration are required. |
format |
Article in Journal/Newspaper |
author |
A Jalali M H Pipelzadeh R Seyedian A H Rahmani N Omidian |
author_facet |
A Jalali M H Pipelzadeh R Seyedian A H Rahmani N Omidian |
author_sort |
A Jalali |
title |
In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom |
title_short |
In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom |
title_full |
In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom |
title_fullStr |
In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom |
title_full_unstemmed |
In vivo pharmacological study on the effectiveness of available polyclonal antivenom against Hemiscorpius lepturus venom |
title_sort |
in vivo pharmacological study on the effectiveness of available polyclonal antivenom against hemiscorpius lepturus venom |
publisher |
SciELO |
publishDate |
2011 |
url |
https://doi.org/10.1590/S1678-91992011000200004 https://doaj.org/article/041f958280a642e4bf43acd5228dfc7a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 17, Iss 2, Pp 142-149 (2011) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000200004 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992011000200004 1678-9199 https://doaj.org/article/041f958280a642e4bf43acd5228dfc7a |
op_doi |
https://doi.org/10.1590/S1678-91992011000200004 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
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17 |
container_issue |
2 |
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142 |
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149 |
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