Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study
Previous studies suggested that dengue was associated with an increased risk of several autoimmune diseases. However, this association still needs to be explored due to the limitations of these studies. A population-based cohort study was conducted using national health databases in Taiwan and inclu...
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ftdoajarticles:oai:doaj.org/article:03a113ad32564c7b8d096e39d2f02f8a 2023-05-15T15:14:14+02:00 Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study Hsin-I Shih Chia-Yu Chi Pei-Fang Tsai Yu-Ping Wang Yu-Wen Chien 2023-03-01T00:00:00Z https://doaj.org/article/03a113ad32564c7b8d096e39d2f02f8a EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990932/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 https://doaj.org/article/03a113ad32564c7b8d096e39d2f02f8a PLoS Neglected Tropical Diseases, Vol 17, Iss 3 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles 2023-03-12T01:30:19Z Previous studies suggested that dengue was associated with an increased risk of several autoimmune diseases. However, this association still needs to be explored due to the limitations of these studies. A population-based cohort study was conducted using national health databases in Taiwan and included 63,814 newly diagnosed, laboratory-confirmed dengue patients between 2002 and 2015 and 1:4 controls (n = 255,256) matched by age, sex, area of residence and symptom onset time. Multivariate Cox proportional hazard regression models were used to investigate the risk of autoimmune diseases after dengue infection. Dengue patients had a slightly higher risk of overall autoimmune diseases than non-dengue controls (aHR 1.16; P = 0.0002). Stratified analyses by specific autoimmune diseases showed that only autoimmune encephalomyelitis remained statistically significant after Bonferroni correction for multiple testing (aHR 2.72; P < 0.0001). Sixteen (0.025%) dengue patients and no (0%) controls developed autoimmune encephalomyelitis in the first month of follow-up (HR >9999, P < 0.0001), but the risk between groups was not significantly different thereafter. Contrary to previous studies, our findings showed that dengue was associated with an increased short-term risk of a rare complication, autoimmune encephalomyelitis, but not associated with other autoimmune diseases. Author summary Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Antibodies produced during dengue infection can cross-react with several self-antigens to the tissues of the body and contribute to thrombocytopenia, coagulopathy, and vascular leakage in severe dengue. Autoimmunity might occur after dengue infection and cause some autoimmune diseases. Previous studies suggested some autoimmune diseases might be associated with dengue infection. Contrary to previous studies, our findings showed that dengue was associated with an increased short-term risk of a rare complication, autoimmune encephalomyelitis, but not ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Hsin-I Shih Chia-Yu Chi Pei-Fang Tsai Yu-Ping Wang Yu-Wen Chien Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Previous studies suggested that dengue was associated with an increased risk of several autoimmune diseases. However, this association still needs to be explored due to the limitations of these studies. A population-based cohort study was conducted using national health databases in Taiwan and included 63,814 newly diagnosed, laboratory-confirmed dengue patients between 2002 and 2015 and 1:4 controls (n = 255,256) matched by age, sex, area of residence and symptom onset time. Multivariate Cox proportional hazard regression models were used to investigate the risk of autoimmune diseases after dengue infection. Dengue patients had a slightly higher risk of overall autoimmune diseases than non-dengue controls (aHR 1.16; P = 0.0002). Stratified analyses by specific autoimmune diseases showed that only autoimmune encephalomyelitis remained statistically significant after Bonferroni correction for multiple testing (aHR 2.72; P < 0.0001). Sixteen (0.025%) dengue patients and no (0%) controls developed autoimmune encephalomyelitis in the first month of follow-up (HR >9999, P < 0.0001), but the risk between groups was not significantly different thereafter. Contrary to previous studies, our findings showed that dengue was associated with an increased short-term risk of a rare complication, autoimmune encephalomyelitis, but not associated with other autoimmune diseases. Author summary Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Antibodies produced during dengue infection can cross-react with several self-antigens to the tissues of the body and contribute to thrombocytopenia, coagulopathy, and vascular leakage in severe dengue. Autoimmunity might occur after dengue infection and cause some autoimmune diseases. Previous studies suggested some autoimmune diseases might be associated with dengue infection. Contrary to previous studies, our findings showed that dengue was associated with an increased short-term risk of a rare complication, autoimmune encephalomyelitis, but not ... |
format |
Article in Journal/Newspaper |
author |
Hsin-I Shih Chia-Yu Chi Pei-Fang Tsai Yu-Ping Wang Yu-Wen Chien |
author_facet |
Hsin-I Shih Chia-Yu Chi Pei-Fang Tsai Yu-Ping Wang Yu-Wen Chien |
author_sort |
Hsin-I Shih |
title |
Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study |
title_short |
Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study |
title_full |
Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study |
title_fullStr |
Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study |
title_full_unstemmed |
Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study |
title_sort |
re-examination of the risk of autoimmune diseases after dengue virus infection: a population-based cohort study |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doaj.org/article/03a113ad32564c7b8d096e39d2f02f8a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 3 (2023) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990932/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 https://doaj.org/article/03a113ad32564c7b8d096e39d2f02f8a |
_version_ |
1766344707503292416 |