Genes that encodes NAGT, MIF1 and MIF2 are not virulence factors for kala-azar caused by Leishmania infantum

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Bruno Guedes Alcoforado Aguiar, Daniela Lemos Coelho, Dorcas Lamounier Costa, Betânia Paiva Drumond, Luiz Felipe Leomil Coelho, Lívio Carvalho Figueiredo, Danielle Alves Zacarias, Jailthon Carlos da Silva, Diego Peres Alonso, Paulo Eduardo Martins Ribolla, Edna Aoba Yassui Ishikawa, Samara Belchior Gaído, Carlos Henrique Nery Costa
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2014
• Subjects: Genetic diversity; Kala-azar; Visceral leishmaniasis; Macrophage inhibition factor; Tropical diseases; Single nucleotide polymorphism; Arctic medicine. Tropical medicine; RC955-962; Arctic; Azar
• Online Access: https://doi.org/10.1590/0037-8682-0183-2014; https://doaj.org/article/0339e28f5f8f4f6f808376c65540e658

Introduction Kala-azar is a disease resulting from infection by Leishmania donovani and Leishmania infantum. Most patients with the disease exhibit prolonged fever, wasting, anemia and hepatosplenomegaly without complications. However, some patients develop severe disease with hemorrhagic manifestat...