Impact of Leishmania mexicana infection on dendritic cell signaling and functions.
Leishmania parasites have the ability to modify macrophage signaling pathways in order to survive and multiply within its mammalian host. They are also known to invade other cells including neutrophils, fibroblasts and dendritic cells (DCs). DCs have an important role in immunity as the link between...
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ftdoajarticles:oai:doaj.org/article:032db9e4671247a5bd2d53ddb4f61051 2023-05-15T15:07:40+02:00 Impact of Leishmania mexicana infection on dendritic cell signaling and functions. Irazú Contreras José A Estrada Hannah Guak Caroline Martel Alborz Borjian Benjamin Ralph Marina T Shio Sylvie Fournier Connie M Krawczyk Martin Olivier 2014-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003202 https://doaj.org/article/032db9e4671247a5bd2d53ddb4f61051 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4177750?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003202 https://doaj.org/article/032db9e4671247a5bd2d53ddb4f61051 PLoS Neglected Tropical Diseases, Vol 8, Iss 9, p e3202 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003202 2022-12-30T21:04:27Z Leishmania parasites have the ability to modify macrophage signaling pathways in order to survive and multiply within its mammalian host. They are also known to invade other cells including neutrophils, fibroblasts and dendritic cells (DCs). DCs have an important role in immunity as the link between innate and adaptive immunity, necessary for the development of an effective response; however, the impact of Leishmania mexicana infection on DCs has been poorly studied. Herein, we report that Leishmania infection rapidly induced DC protein tyrosine phosphatases activity, leading to MAP kinases inactivation. In line with this, L. mexicana was found to decrease the nuclear translocation of transcription factors such as AP-1 and NF-κB. Concomitantly, L. mexicana-infected DCs showed reduced expression of several surface antigen-presenting and co-stimulatory molecules upon LPS stimulation. Leishmania-induced interference on DC maturation was further reflected by their reduced capacity to present OVA antigen to OVA-specific T cells, as shown by abrogation of IL-2 production by the T cells. Collectively, our data revealed that DC infection by L. mexicana appears to affect the cellular and immunological mechanisms necessary for the development of an effective and protective immune response, therefore favouring the survival and propagation of the parasite within its host. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 9 e3202 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Irazú Contreras José A Estrada Hannah Guak Caroline Martel Alborz Borjian Benjamin Ralph Marina T Shio Sylvie Fournier Connie M Krawczyk Martin Olivier Impact of Leishmania mexicana infection on dendritic cell signaling and functions. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Leishmania parasites have the ability to modify macrophage signaling pathways in order to survive and multiply within its mammalian host. They are also known to invade other cells including neutrophils, fibroblasts and dendritic cells (DCs). DCs have an important role in immunity as the link between innate and adaptive immunity, necessary for the development of an effective response; however, the impact of Leishmania mexicana infection on DCs has been poorly studied. Herein, we report that Leishmania infection rapidly induced DC protein tyrosine phosphatases activity, leading to MAP kinases inactivation. In line with this, L. mexicana was found to decrease the nuclear translocation of transcription factors such as AP-1 and NF-κB. Concomitantly, L. mexicana-infected DCs showed reduced expression of several surface antigen-presenting and co-stimulatory molecules upon LPS stimulation. Leishmania-induced interference on DC maturation was further reflected by their reduced capacity to present OVA antigen to OVA-specific T cells, as shown by abrogation of IL-2 production by the T cells. Collectively, our data revealed that DC infection by L. mexicana appears to affect the cellular and immunological mechanisms necessary for the development of an effective and protective immune response, therefore favouring the survival and propagation of the parasite within its host. |
format |
Article in Journal/Newspaper |
author |
Irazú Contreras José A Estrada Hannah Guak Caroline Martel Alborz Borjian Benjamin Ralph Marina T Shio Sylvie Fournier Connie M Krawczyk Martin Olivier |
author_facet |
Irazú Contreras José A Estrada Hannah Guak Caroline Martel Alborz Borjian Benjamin Ralph Marina T Shio Sylvie Fournier Connie M Krawczyk Martin Olivier |
author_sort |
Irazú Contreras |
title |
Impact of Leishmania mexicana infection on dendritic cell signaling and functions. |
title_short |
Impact of Leishmania mexicana infection on dendritic cell signaling and functions. |
title_full |
Impact of Leishmania mexicana infection on dendritic cell signaling and functions. |
title_fullStr |
Impact of Leishmania mexicana infection on dendritic cell signaling and functions. |
title_full_unstemmed |
Impact of Leishmania mexicana infection on dendritic cell signaling and functions. |
title_sort |
impact of leishmania mexicana infection on dendritic cell signaling and functions. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0003202 https://doaj.org/article/032db9e4671247a5bd2d53ddb4f61051 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 9, p e3202 (2014) |
op_relation |
http://europepmc.org/articles/PMC4177750?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003202 https://doaj.org/article/032db9e4671247a5bd2d53ddb4f61051 |
op_doi |
https://doi.org/10.1371/journal.pntd.0003202 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
8 |
container_issue |
9 |
container_start_page |
e3202 |
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1766339116906053632 |