A new approach for monitoring ebolavirus in wild great apes.
Central Africa is a "hotspot" for emerging infectious diseases (EIDs) of global and local importance, and a current outbreak of ebolavirus is affecting multiple countries simultaneously. Ebolavirus is suspected to have caused recent declines in resident great apes. While ebolavirus vaccine...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0003143 https://doaj.org/article/0312dd862c0f413081b0db76134adbef |
id |
ftdoajarticles:oai:doaj.org/article:0312dd862c0f413081b0db76134adbef |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:0312dd862c0f413081b0db76134adbef 2023-05-15T15:10:58+02:00 A new approach for monitoring ebolavirus in wild great apes. Patricia E Reed Sabue Mulangu Kenneth N Cameron Alain U Ondzie Damien Joly Magdalena Bermejo Pierre Rouquet Giulia Fabozzi Michael Bailey Zhimin Shen Brandon F Keele Beatrice Hahn William B Karesh Nancy J Sullivan 2014-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003143 https://doaj.org/article/0312dd862c0f413081b0db76134adbef EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4169258?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003143 https://doaj.org/article/0312dd862c0f413081b0db76134adbef PLoS Neglected Tropical Diseases, Vol 8, Iss 9, p e3143 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003143 2022-12-31T01:48:57Z Central Africa is a "hotspot" for emerging infectious diseases (EIDs) of global and local importance, and a current outbreak of ebolavirus is affecting multiple countries simultaneously. Ebolavirus is suspected to have caused recent declines in resident great apes. While ebolavirus vaccines have been proposed as an intervention to protect apes, their effectiveness would be improved if we could diagnostically confirm Ebola virus disease (EVD) as the cause of die-offs, establish ebolavirus geographical distribution, identify immunologically naïve populations, and determine whether apes survive virus exposure.Here we report the first successful noninvasive detection of antibodies against Ebola virus (EBOV) from wild ape feces. Using this method, we have been able to identify gorillas with antibodies to EBOV with an overall prevalence rate reaching 10% on average, demonstrating that EBOV exposure or infection is not uniformly lethal in this species. Furthermore, evidence of antibodies was identified in gorillas thought previously to be unexposed to EBOV (protected from exposure by rivers as topological barriers of transmission).Our new approach will contribute to a strategy to protect apes from future EBOV infections by early detection of increased incidence of exposure, by identifying immunologically naïve at-risk populations as potential targets for vaccination, and by providing a means to track vaccine efficacy if such intervention is deemed appropriate. Finally, since human EVD is linked to contact with infected wildlife carcasses, efforts aimed at identifying great ape outbreaks could have a profound impact on public health in local communities, where EBOV causes case-fatality rates of up to 88%. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 9 e3143 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Patricia E Reed Sabue Mulangu Kenneth N Cameron Alain U Ondzie Damien Joly Magdalena Bermejo Pierre Rouquet Giulia Fabozzi Michael Bailey Zhimin Shen Brandon F Keele Beatrice Hahn William B Karesh Nancy J Sullivan A new approach for monitoring ebolavirus in wild great apes. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Central Africa is a "hotspot" for emerging infectious diseases (EIDs) of global and local importance, and a current outbreak of ebolavirus is affecting multiple countries simultaneously. Ebolavirus is suspected to have caused recent declines in resident great apes. While ebolavirus vaccines have been proposed as an intervention to protect apes, their effectiveness would be improved if we could diagnostically confirm Ebola virus disease (EVD) as the cause of die-offs, establish ebolavirus geographical distribution, identify immunologically naïve populations, and determine whether apes survive virus exposure.Here we report the first successful noninvasive detection of antibodies against Ebola virus (EBOV) from wild ape feces. Using this method, we have been able to identify gorillas with antibodies to EBOV with an overall prevalence rate reaching 10% on average, demonstrating that EBOV exposure or infection is not uniformly lethal in this species. Furthermore, evidence of antibodies was identified in gorillas thought previously to be unexposed to EBOV (protected from exposure by rivers as topological barriers of transmission).Our new approach will contribute to a strategy to protect apes from future EBOV infections by early detection of increased incidence of exposure, by identifying immunologically naïve at-risk populations as potential targets for vaccination, and by providing a means to track vaccine efficacy if such intervention is deemed appropriate. Finally, since human EVD is linked to contact with infected wildlife carcasses, efforts aimed at identifying great ape outbreaks could have a profound impact on public health in local communities, where EBOV causes case-fatality rates of up to 88%. |
format |
Article in Journal/Newspaper |
author |
Patricia E Reed Sabue Mulangu Kenneth N Cameron Alain U Ondzie Damien Joly Magdalena Bermejo Pierre Rouquet Giulia Fabozzi Michael Bailey Zhimin Shen Brandon F Keele Beatrice Hahn William B Karesh Nancy J Sullivan |
author_facet |
Patricia E Reed Sabue Mulangu Kenneth N Cameron Alain U Ondzie Damien Joly Magdalena Bermejo Pierre Rouquet Giulia Fabozzi Michael Bailey Zhimin Shen Brandon F Keele Beatrice Hahn William B Karesh Nancy J Sullivan |
author_sort |
Patricia E Reed |
title |
A new approach for monitoring ebolavirus in wild great apes. |
title_short |
A new approach for monitoring ebolavirus in wild great apes. |
title_full |
A new approach for monitoring ebolavirus in wild great apes. |
title_fullStr |
A new approach for monitoring ebolavirus in wild great apes. |
title_full_unstemmed |
A new approach for monitoring ebolavirus in wild great apes. |
title_sort |
new approach for monitoring ebolavirus in wild great apes. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0003143 https://doaj.org/article/0312dd862c0f413081b0db76134adbef |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 9, p e3143 (2014) |
op_relation |
http://europepmc.org/articles/PMC4169258?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003143 https://doaj.org/article/0312dd862c0f413081b0db76134adbef |
op_doi |
https://doi.org/10.1371/journal.pntd.0003143 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
8 |
container_issue |
9 |
container_start_page |
e3143 |
_version_ |
1766341893529010176 |