The Molecular Genetic Features of Patients with Juvenile Arthritis in Yakutia
The research objective was to conduct a retrospective study of patients with Juvenile arthritis (JA) in association with the carriage of the HLA-B27 allele. Materials and Methods: A total of 73 patients (39 boys and 34 girls aged from 1 to 16 years, mean age of 10.28±4.24 years) living in Yakutia wi...
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International Medical Research and Development Corporation
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ftdoajarticles:oai:doaj.org/article:0303ded5554a404a821ef796087cc9ca 2023-05-15T18:44:58+02:00 The Molecular Genetic Features of Patients with Juvenile Arthritis in Yakutia Khariton A. Kurtanov ¹; Fekla V. Vinokurova Nadezhda I. Pavlova Aitalina S. Golderova Aleksandra T. Diakonova Galina A. Apsolikhova Vlad A. Alekseev 2019-06-01T00:00:00Z https://doi.org/10.21103/Article9(2)_OA7 https://doaj.org/article/0303ded5554a404a821ef796087cc9ca EN eng International Medical Research and Development Corporation http://ijbm.org/articles/IJBM_9(2)_OA7.pdf https://doaj.org/toc/2158-0510 https://doaj.org/toc/2158-0529 doi:10.21103/Article9(2)_OA7 2158-0510 2158-0529 https://doaj.org/article/0303ded5554a404a821ef796087cc9ca International Journal of Biomedicine, Vol 9, Iss 2, Pp 121-124 (2019) Juvenile ankylosing spondylitis HLA-B27 Yakuts Medicine R article 2019 ftdoajarticles https://doi.org/10.21103/Article9(2)_OA7 2022-12-31T02:56:17Z The research objective was to conduct a retrospective study of patients with Juvenile arthritis (JA) in association with the carriage of the HLA-B27 allele. Materials and Methods: A total of 73 patients (39 boys and 34 girls aged from 1 to 16 years, mean age of 10.28±4.24 years) living in Yakutia with Juvenile Chronic Arthritis (JCA), Juvenile Ankylosing Spondylitis (JAS), Juvenile Psoriatic Arthritis (JPsA), and reactive arthritis (RA) were examined. Among them, 62(84.9%) children were of Yakut nationality, and 11(15.1%) – the Russian nationality. The control group included 85 Yakuts without clinical diagnosis of arthritis. Testing for the HLA-B27 allele was performed according to Dominquez et al. (1992) as modified by Steffens-Nakken et al. (1995). Results: According to the genotyping results, in 30 of 73 examined samples an association was found between the HLA-B27 allele carriage and JA. The HLA-B27 allele was diagnosed in 24(38.7%) Yakuts and 6(54.5%) ethnic Russians. For further analysis, all patients (Yakuts, Russians) were divided into diagnosis-related groups. Diagnoses of JAS (n=10) and JCA (n=9) prevailed in Yakuts. In the Russian children, RA was more common (n=4). In population sampling of Yakuts, the frequency of the HLA-B27 allele was 33%. A comparison of the frequencies of the HLA-B27 allele among the Yakut patient groups and the control group found a statistically significant association with JAS. The carriage of the HLA-B27 allele in Yakut females did not increase the risk of JAS development, whereas in male Yakuts this risk increased by 5.6 times. Article in Journal/Newspaper Yakutia Yakuts Directory of Open Access Journals: DOAJ Articles Nakken ENVELOPE(13.235,13.235,65.700,65.700) International Journal of Biomedicine 9 2 121 124 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Juvenile ankylosing spondylitis HLA-B27 Yakuts Medicine R |
spellingShingle |
Juvenile ankylosing spondylitis HLA-B27 Yakuts Medicine R Khariton A. Kurtanov ¹; Fekla V. Vinokurova Nadezhda I. Pavlova Aitalina S. Golderova Aleksandra T. Diakonova Galina A. Apsolikhova Vlad A. Alekseev The Molecular Genetic Features of Patients with Juvenile Arthritis in Yakutia |
topic_facet |
Juvenile ankylosing spondylitis HLA-B27 Yakuts Medicine R |
description |
The research objective was to conduct a retrospective study of patients with Juvenile arthritis (JA) in association with the carriage of the HLA-B27 allele. Materials and Methods: A total of 73 patients (39 boys and 34 girls aged from 1 to 16 years, mean age of 10.28±4.24 years) living in Yakutia with Juvenile Chronic Arthritis (JCA), Juvenile Ankylosing Spondylitis (JAS), Juvenile Psoriatic Arthritis (JPsA), and reactive arthritis (RA) were examined. Among them, 62(84.9%) children were of Yakut nationality, and 11(15.1%) – the Russian nationality. The control group included 85 Yakuts without clinical diagnosis of arthritis. Testing for the HLA-B27 allele was performed according to Dominquez et al. (1992) as modified by Steffens-Nakken et al. (1995). Results: According to the genotyping results, in 30 of 73 examined samples an association was found between the HLA-B27 allele carriage and JA. The HLA-B27 allele was diagnosed in 24(38.7%) Yakuts and 6(54.5%) ethnic Russians. For further analysis, all patients (Yakuts, Russians) were divided into diagnosis-related groups. Diagnoses of JAS (n=10) and JCA (n=9) prevailed in Yakuts. In the Russian children, RA was more common (n=4). In population sampling of Yakuts, the frequency of the HLA-B27 allele was 33%. A comparison of the frequencies of the HLA-B27 allele among the Yakut patient groups and the control group found a statistically significant association with JAS. The carriage of the HLA-B27 allele in Yakut females did not increase the risk of JAS development, whereas in male Yakuts this risk increased by 5.6 times. |
format |
Article in Journal/Newspaper |
author |
Khariton A. Kurtanov ¹; Fekla V. Vinokurova Nadezhda I. Pavlova Aitalina S. Golderova Aleksandra T. Diakonova Galina A. Apsolikhova Vlad A. Alekseev |
author_facet |
Khariton A. Kurtanov ¹; Fekla V. Vinokurova Nadezhda I. Pavlova Aitalina S. Golderova Aleksandra T. Diakonova Galina A. Apsolikhova Vlad A. Alekseev |
author_sort |
Khariton A. Kurtanov |
title |
The Molecular Genetic Features of Patients with Juvenile Arthritis in Yakutia |
title_short |
The Molecular Genetic Features of Patients with Juvenile Arthritis in Yakutia |
title_full |
The Molecular Genetic Features of Patients with Juvenile Arthritis in Yakutia |
title_fullStr |
The Molecular Genetic Features of Patients with Juvenile Arthritis in Yakutia |
title_full_unstemmed |
The Molecular Genetic Features of Patients with Juvenile Arthritis in Yakutia |
title_sort |
molecular genetic features of patients with juvenile arthritis in yakutia |
publisher |
International Medical Research and Development Corporation |
publishDate |
2019 |
url |
https://doi.org/10.21103/Article9(2)_OA7 https://doaj.org/article/0303ded5554a404a821ef796087cc9ca |
long_lat |
ENVELOPE(13.235,13.235,65.700,65.700) |
geographic |
Nakken |
geographic_facet |
Nakken |
genre |
Yakutia Yakuts |
genre_facet |
Yakutia Yakuts |
op_source |
International Journal of Biomedicine, Vol 9, Iss 2, Pp 121-124 (2019) |
op_relation |
http://ijbm.org/articles/IJBM_9(2)_OA7.pdf https://doaj.org/toc/2158-0510 https://doaj.org/toc/2158-0529 doi:10.21103/Article9(2)_OA7 2158-0510 2158-0529 https://doaj.org/article/0303ded5554a404a821ef796087cc9ca |
op_doi |
https://doi.org/10.21103/Article9(2)_OA7 |
container_title |
International Journal of Biomedicine |
container_volume |
9 |
container_issue |
2 |
container_start_page |
121 |
op_container_end_page |
124 |
_version_ |
1766235860743749632 |