Analysis of Preferences in the Use of Fixed-Doses Combinations Antihypertensive Drugs in the Regions of Far-Eastern Federal District

• Main Authors: Soboleva MS, Loskutova EE
• Format: Article in Journal/Newspaper
• Language: English
• Published: Dove Medical Press 2020
• Subjects: arterial hypertension; fixed-dose combinations; pharmaceutical market; far eastern federal district; russian federation; acquisition of drugs; intra-group analysis; Medicine (General); R5-920; Therapeutics. Pharmacology; RM1-950; Magadan; Sakhalin
• Online Access: https://doaj.org/article/02c1b809e66840d789469179ec545c6a

Mariia Sergeevna Soboleva,1 Ekaterina Efimovna Loskutova2 1Department of Pharmacy and Pharmacology, The Far-Eastern State Medical University, Khabarovsk, 680000, Russian Federation; 2Peoples’ Friendship University of Russia Medical Faculty, Moscow 117198, Russian FederationCorrespondence: Mariia Sergeevna Soboleva Email [e-mail]: Diseases characterized by elevated blood pressure are the most frequently diagnosed pathology among socially significant diseases in the Russian Federation. According to clinical recommendations of the Russian Medical Society for Arterial Hypertension 2010– 2019, the use of two and more component drugs improves the compliance of patients to treatment. The purpose of this study was a comparative analysis of preferences in the usage of combined antihypertensive drugs in ten regions of the Far Eastern Federal District (FSD).Materials and Methods: Intra-group analysis of data on the sale of antihypertensive drugs in pharmacy organizations (162 drugstores) for the period 2018 was carried out in the 10 regions of the FSD. The sample is uneven due to the difference in total number of drugstores in the regions. The sample was random. Pharmacies were in urban and rural areas. The total purchase of all defined daily doses of all antihypertensive drugs was taken as 100%. Then, fixed-dose combinations were selected. The share of each drug in the sales structure was then calculated. Kruskal–Wallis criterion was used for determining the differences in the structure of acquisition of drugs between the regions. The Spearman’s rank correlation and factor analysis were used for determining the correlation between the drug’s acquisition structure and the FSD region.Results: Two-component drugs are most in demand in the Amur region – 15.2% and Zabaykalsky Krai – 12.3%, and the lowest demand in the Sakhalin region – 5.25% and Magadan region – 6.5%. The largest sales indicators of three-component drugs were observed in the Zabaykalsky Krai – 1.2% and the Republic of Buryatia – 1.0%. The ...