Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects
Abstract Background The world has made great strides towards beating malaria, although about half of the world population is still exposed to the risk of contracting malaria. Developing an effective malaria vaccine was a huge challenge for medical science. In 2021 the World Health Organization (WHO)...
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ftdoajarticles:oai:doaj.org/article:02c19d9c8243470ba9316bc352137d41 2023-06-11T04:09:38+02:00 Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects Amal A. El-Moamly Mohamed A. El-Sweify 2023-05-01T00:00:00Z https://doi.org/10.1186/s41182-023-00516-w https://doaj.org/article/02c19d9c8243470ba9316bc352137d41 EN eng BMC https://doi.org/10.1186/s41182-023-00516-w https://doaj.org/toc/1349-4147 doi:10.1186/s41182-023-00516-w 1349-4147 https://doaj.org/article/02c19d9c8243470ba9316bc352137d41 Tropical Medicine and Health, Vol 51, Iss 1, Pp 1-18 (2023) Malaria Plasmodium falciparum Vaccine Development History Challenges Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.1186/s41182-023-00516-w 2023-05-28T00:37:56Z Abstract Background The world has made great strides towards beating malaria, although about half of the world population is still exposed to the risk of contracting malaria. Developing an effective malaria vaccine was a huge challenge for medical science. In 2021 the World Health Organization (WHO) approved the first malaria vaccine, RTS,S/AS01 vaccine (Mosquirix™), for widespread use. Main abstract body This review highlights the history of development, and the different approaches and types of malaria vaccines, and the literature to date. It covers the developmental stages of RTS,S/AS01 and recommends steps for its deployment. The review explores other potential vaccine candidates and their status, and suggests options for their further development. It also recommends future roles for vaccines in eradicating malaria. Questions remain on how RTS,S vaccine will work in widespread use and how it can best be utilized to benefit vulnerable communities. Conclusion Malaria vaccines have been in development for almost 60 years. The RTS,S/AS01 vaccine has now been approved, but cannot be a stand-alone solution. Development should continue on promising candidates such as R21, PfSPZ and P. vivax vaccines. Multi-component vaccines may be a useful addition to other malaria control techniques in achieving eradication of malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Tropical Medicine and Health 51 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Malaria Plasmodium falciparum Vaccine Development History Challenges Arctic medicine. Tropical medicine RC955-962 |
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Malaria Plasmodium falciparum Vaccine Development History Challenges Arctic medicine. Tropical medicine RC955-962 Amal A. El-Moamly Mohamed A. El-Sweify Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects |
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Malaria Plasmodium falciparum Vaccine Development History Challenges Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background The world has made great strides towards beating malaria, although about half of the world population is still exposed to the risk of contracting malaria. Developing an effective malaria vaccine was a huge challenge for medical science. In 2021 the World Health Organization (WHO) approved the first malaria vaccine, RTS,S/AS01 vaccine (Mosquirix™), for widespread use. Main abstract body This review highlights the history of development, and the different approaches and types of malaria vaccines, and the literature to date. It covers the developmental stages of RTS,S/AS01 and recommends steps for its deployment. The review explores other potential vaccine candidates and their status, and suggests options for their further development. It also recommends future roles for vaccines in eradicating malaria. Questions remain on how RTS,S vaccine will work in widespread use and how it can best be utilized to benefit vulnerable communities. Conclusion Malaria vaccines have been in development for almost 60 years. The RTS,S/AS01 vaccine has now been approved, but cannot be a stand-alone solution. Development should continue on promising candidates such as R21, PfSPZ and P. vivax vaccines. Multi-component vaccines may be a useful addition to other malaria control techniques in achieving eradication of malaria. |
format |
Article in Journal/Newspaper |
author |
Amal A. El-Moamly Mohamed A. El-Sweify |
author_facet |
Amal A. El-Moamly Mohamed A. El-Sweify |
author_sort |
Amal A. El-Moamly |
title |
Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects |
title_short |
Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects |
title_full |
Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects |
title_fullStr |
Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects |
title_full_unstemmed |
Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects |
title_sort |
malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects |
publisher |
BMC |
publishDate |
2023 |
url |
https://doi.org/10.1186/s41182-023-00516-w https://doaj.org/article/02c19d9c8243470ba9316bc352137d41 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Medicine and Health, Vol 51, Iss 1, Pp 1-18 (2023) |
op_relation |
https://doi.org/10.1186/s41182-023-00516-w https://doaj.org/toc/1349-4147 doi:10.1186/s41182-023-00516-w 1349-4147 https://doaj.org/article/02c19d9c8243470ba9316bc352137d41 |
op_doi |
https://doi.org/10.1186/s41182-023-00516-w |
container_title |
Tropical Medicine and Health |
container_volume |
51 |
container_issue |
1 |
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1768383597559939072 |