Anti-hyperglycemic effects of aqueous Lenzites betulina extracts from the Philippines on the blood glucose levels of the ICR mice (Mus musculus)
Objective: To examine the anti-hyperglycemic effects of aqueous Lenzites betulina (L. betulina) extracts on normoglycemic glucose-loaded mice. Methods: Different doses of aqueous extract from L. betulina were administered to 45 ICR mice (Mus musculus) to determine whether there was an effect of L. b...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
2016
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Online Access: | https://doi.org/10.1016/j.apjtb.2015.04.013 https://doaj.org/article/02b2d9ff09c449f19bbc393f4533d723 |
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ftdoajarticles:oai:doaj.org/article:02b2d9ff09c449f19bbc393f4533d723 2023-05-15T15:18:32+02:00 Anti-hyperglycemic effects of aqueous Lenzites betulina extracts from the Philippines on the blood glucose levels of the ICR mice (Mus musculus) Faizal Rajeeb Mangudadatu Hussin Rodel Jonathan Santos Vitor, II Julie Ann Oraa Joaquin Melody Mendoza Clerigo Anamy Ma. Caterial Paano 2016-02-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2015.04.013 https://doaj.org/article/02b2d9ff09c449f19bbc393f4533d723 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115002609 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.04.013 https://doaj.org/article/02b2d9ff09c449f19bbc393f4533d723 Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 2, Pp 155-158 (2016) Anti-hyperglycemic Glucose Lenzites betulina ICR mice Oral glucose tolerance test Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2016 ftdoajarticles https://doi.org/10.1016/j.apjtb.2015.04.013 2022-12-31T10:15:32Z Objective: To examine the anti-hyperglycemic effects of aqueous Lenzites betulina (L. betulina) extracts on normoglycemic glucose-loaded mice. Methods: Different doses of aqueous extract from L. betulina were administered to 45 ICR mice (Mus musculus) to determine whether there was an effect of L. betulina extracts on the blood glucose level of the ICR mice. Aqueous extracts of L. betulina were orally gavaged to mice using oral glucose tolerance test. A total of five groups were used to determine the effect of the fungi on blood glucose of the mice. Group A (positive control) was given 16.7 μg/kg glimepiride; Group B (negative control) was given distilled water; Group C (low dosage) was given 200 mg/kg aqueous extract; Group D (mid dosage) was given 400 mg/kg aqueous extract and Group E (high dosage) was given 800 mg/kg aqueous extract. Baseline blood glucose value was firstly acquired before induction of hyperglycemia through d-glucose, after which another check on blood glucose was made after 0.5 h. Immediately, after the acquisition of hyperglycemic blood glucose level, the individual administration of treatments were done. After that, three blood collections were done spanning 3 h with 1 h interval. Results: The low dose (200 mg/kg) and the mid dose (400 mg/kg) of L. betulina extracts were significantly different (P < 0.05) from their respective baseline values throughout the whole experiment with the latter surpassing its baseline value during the 3rd hour. On the other hand, the high dose (800 mg/kg) during the 1st hour after administration was not significantly different (P > 0.05) from its corresponding baseline value, acting faster than the positive control (glimepiride), which only became significantly different (P < 0.05) at the 2nd hour. Conclusions: Aqueous L. betulina extract is able to produce hypoglycemic effects on the mice with all doses, which are able to normalize blood glucose levels at varying times. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 6 2 155 158 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Anti-hyperglycemic Glucose Lenzites betulina ICR mice Oral glucose tolerance test Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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Anti-hyperglycemic Glucose Lenzites betulina ICR mice Oral glucose tolerance test Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Faizal Rajeeb Mangudadatu Hussin Rodel Jonathan Santos Vitor, II Julie Ann Oraa Joaquin Melody Mendoza Clerigo Anamy Ma. Caterial Paano Anti-hyperglycemic effects of aqueous Lenzites betulina extracts from the Philippines on the blood glucose levels of the ICR mice (Mus musculus) |
topic_facet |
Anti-hyperglycemic Glucose Lenzites betulina ICR mice Oral glucose tolerance test Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To examine the anti-hyperglycemic effects of aqueous Lenzites betulina (L. betulina) extracts on normoglycemic glucose-loaded mice. Methods: Different doses of aqueous extract from L. betulina were administered to 45 ICR mice (Mus musculus) to determine whether there was an effect of L. betulina extracts on the blood glucose level of the ICR mice. Aqueous extracts of L. betulina were orally gavaged to mice using oral glucose tolerance test. A total of five groups were used to determine the effect of the fungi on blood glucose of the mice. Group A (positive control) was given 16.7 μg/kg glimepiride; Group B (negative control) was given distilled water; Group C (low dosage) was given 200 mg/kg aqueous extract; Group D (mid dosage) was given 400 mg/kg aqueous extract and Group E (high dosage) was given 800 mg/kg aqueous extract. Baseline blood glucose value was firstly acquired before induction of hyperglycemia through d-glucose, after which another check on blood glucose was made after 0.5 h. Immediately, after the acquisition of hyperglycemic blood glucose level, the individual administration of treatments were done. After that, three blood collections were done spanning 3 h with 1 h interval. Results: The low dose (200 mg/kg) and the mid dose (400 mg/kg) of L. betulina extracts were significantly different (P < 0.05) from their respective baseline values throughout the whole experiment with the latter surpassing its baseline value during the 3rd hour. On the other hand, the high dose (800 mg/kg) during the 1st hour after administration was not significantly different (P > 0.05) from its corresponding baseline value, acting faster than the positive control (glimepiride), which only became significantly different (P < 0.05) at the 2nd hour. Conclusions: Aqueous L. betulina extract is able to produce hypoglycemic effects on the mice with all doses, which are able to normalize blood glucose levels at varying times. |
format |
Article in Journal/Newspaper |
author |
Faizal Rajeeb Mangudadatu Hussin Rodel Jonathan Santos Vitor, II Julie Ann Oraa Joaquin Melody Mendoza Clerigo Anamy Ma. Caterial Paano |
author_facet |
Faizal Rajeeb Mangudadatu Hussin Rodel Jonathan Santos Vitor, II Julie Ann Oraa Joaquin Melody Mendoza Clerigo Anamy Ma. Caterial Paano |
author_sort |
Faizal Rajeeb Mangudadatu Hussin |
title |
Anti-hyperglycemic effects of aqueous Lenzites betulina extracts from the Philippines on the blood glucose levels of the ICR mice (Mus musculus) |
title_short |
Anti-hyperglycemic effects of aqueous Lenzites betulina extracts from the Philippines on the blood glucose levels of the ICR mice (Mus musculus) |
title_full |
Anti-hyperglycemic effects of aqueous Lenzites betulina extracts from the Philippines on the blood glucose levels of the ICR mice (Mus musculus) |
title_fullStr |
Anti-hyperglycemic effects of aqueous Lenzites betulina extracts from the Philippines on the blood glucose levels of the ICR mice (Mus musculus) |
title_full_unstemmed |
Anti-hyperglycemic effects of aqueous Lenzites betulina extracts from the Philippines on the blood glucose levels of the ICR mice (Mus musculus) |
title_sort |
anti-hyperglycemic effects of aqueous lenzites betulina extracts from the philippines on the blood glucose levels of the icr mice (mus musculus) |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2016 |
url |
https://doi.org/10.1016/j.apjtb.2015.04.013 https://doaj.org/article/02b2d9ff09c449f19bbc393f4533d723 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 2, Pp 155-158 (2016) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115002609 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.04.013 https://doaj.org/article/02b2d9ff09c449f19bbc393f4533d723 |
op_doi |
https://doi.org/10.1016/j.apjtb.2015.04.013 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
6 |
container_issue |
2 |
container_start_page |
155 |
op_container_end_page |
158 |
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1766348726634283008 |