An outbreak of Leishmania major from an endemic to a non-endemic region posed a public health threat in Iraq from 2014-2017: Epidemiological, molecular and phylogenetic studies.
Cutaneous leishmaniasis (CL) is a neglected worldwide, zoonotic, vector-borne, tropical disease that is a threat to public health. This threat may spread from endemic to non-endemic areas. Current research has exploited epidemiological, molecular and phylogenetical studies to determine the danger of...
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ftdoajarticles:oai:doaj.org/article:027050f0ecd4496ea56179b662843c27 2023-05-15T15:07:16+02:00 An outbreak of Leishmania major from an endemic to a non-endemic region posed a public health threat in Iraq from 2014-2017: Epidemiological, molecular and phylogenetic studies. Mariwan M M Al-Bajalan Sirwan M A Al-Jaf Sherko S Niranji Dler R Abdulkareem Khudhair K Al-Kayali Hirotomo Kato 2018-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006255 https://doaj.org/article/027050f0ecd4496ea56179b662843c27 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5832184?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006255 https://doaj.org/article/027050f0ecd4496ea56179b662843c27 PLoS Neglected Tropical Diseases, Vol 12, Iss 3, p e0006255 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006255 2022-12-31T14:07:20Z Cutaneous leishmaniasis (CL) is a neglected worldwide, zoonotic, vector-borne, tropical disease that is a threat to public health. This threat may spread from endemic to non-endemic areas. Current research has exploited epidemiological, molecular and phylogenetical studies to determine the danger of an outbreak of CL in the borderline area between northern and central Iraq from 2014-2017.For the first time, using sequence analysis of the cytochrome b gene, the occurrence of CL in the borderline area between northern and central Iraq was confirmed to be due to Leishmania major. The phylogenetic analysis indicated that it was closely related to the L. major MRHO/IR/75/ER strain in Iran.In conclusion, the genotype confirmation of the L. major strain will improve our understanding of the epidemiology of the disease. This is important for facilitating control programs to prevent the further spread of CL. Furthermore, this area could be considered as a model for further research on the risk of global CL epidemics in other non-endemic countries where both reservoir hosts and sandfly vectors are present. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 3 e0006255 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Mariwan M M Al-Bajalan Sirwan M A Al-Jaf Sherko S Niranji Dler R Abdulkareem Khudhair K Al-Kayali Hirotomo Kato An outbreak of Leishmania major from an endemic to a non-endemic region posed a public health threat in Iraq from 2014-2017: Epidemiological, molecular and phylogenetic studies. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Cutaneous leishmaniasis (CL) is a neglected worldwide, zoonotic, vector-borne, tropical disease that is a threat to public health. This threat may spread from endemic to non-endemic areas. Current research has exploited epidemiological, molecular and phylogenetical studies to determine the danger of an outbreak of CL in the borderline area between northern and central Iraq from 2014-2017.For the first time, using sequence analysis of the cytochrome b gene, the occurrence of CL in the borderline area between northern and central Iraq was confirmed to be due to Leishmania major. The phylogenetic analysis indicated that it was closely related to the L. major MRHO/IR/75/ER strain in Iran.In conclusion, the genotype confirmation of the L. major strain will improve our understanding of the epidemiology of the disease. This is important for facilitating control programs to prevent the further spread of CL. Furthermore, this area could be considered as a model for further research on the risk of global CL epidemics in other non-endemic countries where both reservoir hosts and sandfly vectors are present. |
format |
Article in Journal/Newspaper |
author |
Mariwan M M Al-Bajalan Sirwan M A Al-Jaf Sherko S Niranji Dler R Abdulkareem Khudhair K Al-Kayali Hirotomo Kato |
author_facet |
Mariwan M M Al-Bajalan Sirwan M A Al-Jaf Sherko S Niranji Dler R Abdulkareem Khudhair K Al-Kayali Hirotomo Kato |
author_sort |
Mariwan M M Al-Bajalan |
title |
An outbreak of Leishmania major from an endemic to a non-endemic region posed a public health threat in Iraq from 2014-2017: Epidemiological, molecular and phylogenetic studies. |
title_short |
An outbreak of Leishmania major from an endemic to a non-endemic region posed a public health threat in Iraq from 2014-2017: Epidemiological, molecular and phylogenetic studies. |
title_full |
An outbreak of Leishmania major from an endemic to a non-endemic region posed a public health threat in Iraq from 2014-2017: Epidemiological, molecular and phylogenetic studies. |
title_fullStr |
An outbreak of Leishmania major from an endemic to a non-endemic region posed a public health threat in Iraq from 2014-2017: Epidemiological, molecular and phylogenetic studies. |
title_full_unstemmed |
An outbreak of Leishmania major from an endemic to a non-endemic region posed a public health threat in Iraq from 2014-2017: Epidemiological, molecular and phylogenetic studies. |
title_sort |
outbreak of leishmania major from an endemic to a non-endemic region posed a public health threat in iraq from 2014-2017: epidemiological, molecular and phylogenetic studies. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006255 https://doaj.org/article/027050f0ecd4496ea56179b662843c27 |
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Arctic |
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Arctic |
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Arctic |
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Arctic |
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PLoS Neglected Tropical Diseases, Vol 12, Iss 3, p e0006255 (2018) |
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http://europepmc.org/articles/PMC5832184?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006255 https://doaj.org/article/027050f0ecd4496ea56179b662843c27 |
op_doi |
https://doi.org/10.1371/journal.pntd.0006255 |
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PLOS Neglected Tropical Diseases |
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12 |
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3 |
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e0006255 |
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