Epidemiological, clinical and radiological characteristics of people with neurocysticercosis in Tanzania–A cross-sectional study
Background Neurocysticercosis (NCC) is common among people with epilepsy in low-resource settings. Prevalence of NCC and radiological characteristics of patients with NCC vary considerably even within small areas but differences have been poorly characterized so far. Methods We conducted a cross-sec...
Main Authors: | , , , , , , , , , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2022
|
Subjects: | |
Online Access: | https://doaj.org/article/026a914443f3456fbcf5f31a90dd36c2 |
id |
ftdoajarticles:oai:doaj.org/article:026a914443f3456fbcf5f31a90dd36c2 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:026a914443f3456fbcf5f31a90dd36c2 2023-05-15T15:16:20+02:00 Epidemiological, clinical and radiological characteristics of people with neurocysticercosis in Tanzania–A cross-sectional study Dominik Stelzle Charles Makasi Veronika Schmidt Chiara Trevisan Inge van Damme Tamara M. Welte Charlotte Ruether Agnes Fleury Pierre Dorny Pascal Magnussen Gideon Zulu Kabemba E. Mwape Emmanuel Bottieau Sarah Gabriël Bernard J. Ngowi Andrea S. Winkler 2022-11-01T00:00:00Z https://doaj.org/article/026a914443f3456fbcf5f31a90dd36c2 EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704569/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 https://doaj.org/article/026a914443f3456fbcf5f31a90dd36c2 PLoS Neglected Tropical Diseases, Vol 16, Iss 11 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles 2022-12-30T19:40:11Z Background Neurocysticercosis (NCC) is common among people with epilepsy in low-resource settings. Prevalence of NCC and radiological characteristics of patients with NCC vary considerably even within small areas but differences have been poorly characterized so far. Methods We conducted a cross-sectional study between August 2018 and April 2020 in three district hospitals in southern Tanzania (Ifisi, Tukuyu and Vwawa). Patients with and without epileptic seizures were included in this study. All patients were tested with a novel antibody-detecting point-of-care test for the diagnosis of Taenia solium cysticercosis. All test positives and a subset of test negatives had a further clinical work-up including medical examination and computed tomography of the brain. NCC was defined according to the Del Brutto criteria. We assessed epidemiological, clinical and radiological characteristics of patients with NCC by presence of epileptic seizures and by serology status. Results In all three district hospitals, more than 30% of all people with epileptic seizures (PWE) had NCC lesions in their brain (38% in Vwawa, 32% in Tukuyu and 31% in Ifisi). Most PWE with NCC had multiple lesions and mostly parenchymal lesions (at least 85%). If patients were serologically positive, they had in the median more lesions than serologically negative patients (15 [interquartile range 8–29] versus 5 [1.8–11]), and only serologically positive patients had active stage lesions. Furthermore, serologically positive PWE had more lesions than serologically positive people without epileptic seizures (10.5 [7–23]), and more often had active lesions. PWE diagnosed with NCC (n = 53) were older, and more commonly had focal onset seizures (68% versus 44%, p = 0.03) and headache episodes (34% versus 14%, p = 0.06), which were also stronger than in PWE without NCC (p = 0.04). Conclusion NCC is common among PWE. A combination of clinical and serological factors could help to establish an algorithm to identify patients potentially suffering from active ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Brutto ENVELOPE(20.743,20.743,69.985,69.985) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Dominik Stelzle Charles Makasi Veronika Schmidt Chiara Trevisan Inge van Damme Tamara M. Welte Charlotte Ruether Agnes Fleury Pierre Dorny Pascal Magnussen Gideon Zulu Kabemba E. Mwape Emmanuel Bottieau Sarah Gabriël Bernard J. Ngowi Andrea S. Winkler Epidemiological, clinical and radiological characteristics of people with neurocysticercosis in Tanzania–A cross-sectional study |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Neurocysticercosis (NCC) is common among people with epilepsy in low-resource settings. Prevalence of NCC and radiological characteristics of patients with NCC vary considerably even within small areas but differences have been poorly characterized so far. Methods We conducted a cross-sectional study between August 2018 and April 2020 in three district hospitals in southern Tanzania (Ifisi, Tukuyu and Vwawa). Patients with and without epileptic seizures were included in this study. All patients were tested with a novel antibody-detecting point-of-care test for the diagnosis of Taenia solium cysticercosis. All test positives and a subset of test negatives had a further clinical work-up including medical examination and computed tomography of the brain. NCC was defined according to the Del Brutto criteria. We assessed epidemiological, clinical and radiological characteristics of patients with NCC by presence of epileptic seizures and by serology status. Results In all three district hospitals, more than 30% of all people with epileptic seizures (PWE) had NCC lesions in their brain (38% in Vwawa, 32% in Tukuyu and 31% in Ifisi). Most PWE with NCC had multiple lesions and mostly parenchymal lesions (at least 85%). If patients were serologically positive, they had in the median more lesions than serologically negative patients (15 [interquartile range 8–29] versus 5 [1.8–11]), and only serologically positive patients had active stage lesions. Furthermore, serologically positive PWE had more lesions than serologically positive people without epileptic seizures (10.5 [7–23]), and more often had active lesions. PWE diagnosed with NCC (n = 53) were older, and more commonly had focal onset seizures (68% versus 44%, p = 0.03) and headache episodes (34% versus 14%, p = 0.06), which were also stronger than in PWE without NCC (p = 0.04). Conclusion NCC is common among PWE. A combination of clinical and serological factors could help to establish an algorithm to identify patients potentially suffering from active ... |
format |
Article in Journal/Newspaper |
author |
Dominik Stelzle Charles Makasi Veronika Schmidt Chiara Trevisan Inge van Damme Tamara M. Welte Charlotte Ruether Agnes Fleury Pierre Dorny Pascal Magnussen Gideon Zulu Kabemba E. Mwape Emmanuel Bottieau Sarah Gabriël Bernard J. Ngowi Andrea S. Winkler |
author_facet |
Dominik Stelzle Charles Makasi Veronika Schmidt Chiara Trevisan Inge van Damme Tamara M. Welte Charlotte Ruether Agnes Fleury Pierre Dorny Pascal Magnussen Gideon Zulu Kabemba E. Mwape Emmanuel Bottieau Sarah Gabriël Bernard J. Ngowi Andrea S. Winkler |
author_sort |
Dominik Stelzle |
title |
Epidemiological, clinical and radiological characteristics of people with neurocysticercosis in Tanzania–A cross-sectional study |
title_short |
Epidemiological, clinical and radiological characteristics of people with neurocysticercosis in Tanzania–A cross-sectional study |
title_full |
Epidemiological, clinical and radiological characteristics of people with neurocysticercosis in Tanzania–A cross-sectional study |
title_fullStr |
Epidemiological, clinical and radiological characteristics of people with neurocysticercosis in Tanzania–A cross-sectional study |
title_full_unstemmed |
Epidemiological, clinical and radiological characteristics of people with neurocysticercosis in Tanzania–A cross-sectional study |
title_sort |
epidemiological, clinical and radiological characteristics of people with neurocysticercosis in tanzania–a cross-sectional study |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doaj.org/article/026a914443f3456fbcf5f31a90dd36c2 |
long_lat |
ENVELOPE(20.743,20.743,69.985,69.985) |
geographic |
Arctic Brutto |
geographic_facet |
Arctic Brutto |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 11 (2022) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704569/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 https://doaj.org/article/026a914443f3456fbcf5f31a90dd36c2 |
_version_ |
1766346627254059008 |