Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North
Scientific medical literature has accumulated a lot of data suggesting most important components of coronary heart disease pathogenesis and hypertension to be complex triggering processes of neuro-immune and neuro-endocrine interactions. Risk factors for cardiovascular diseases at the initial stages...
Published in: | Medical Immunology (Russia) |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2021
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Online Access: | https://doi.org/10.15789/1563-0625-EVF-2160 https://doaj.org/article/025ac9827a774657b13f648cb8f4bdad |
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ftdoajarticles:oai:doaj.org/article:025ac9827a774657b13f648cb8f4bdad 2024-09-09T19:28:19+00:00 Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North A. V. Gertsev Yu. N. Zakrevskii V. N. Ischuk 2021-06-01T00:00:00Z https://doi.org/10.15789/1563-0625-EVF-2160 https://doaj.org/article/025ac9827a774657b13f648cb8f4bdad RU rus St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists https://www.mimmun.ru/mimmun/article/view/2191 https://doaj.org/toc/1563-0625 https://doaj.org/toc/2313-741X 1563-0625 2313-741X doi:10.15789/1563-0625-EVF-2160 https://doaj.org/article/025ac9827a774657b13f648cb8f4bdad Медицинская иммунология, Vol 23, Iss 3, Pp 541-556 (2021) neuropeptide-cytokine status ischemic heart disease hypertension atherosclerosis anxiety-depressive disorders p-endorphin cytokines Immunologic diseases. Allergy RC581-607 article 2021 ftdoajarticles https://doi.org/10.15789/1563-0625-EVF-2160 2024-08-05T17:48:49Z Scientific medical literature has accumulated a lot of data suggesting most important components of coronary heart disease pathogenesis and hypertension to be complex triggering processes of neuro-immune and neuro-endocrine interactions. Risk factors for cardiovascular diseases at the initial stages of atherosclerosis formation cause endothelial dysfunction and trigger a cascade of immune inflammation in coronary vessels, which is based on shifting immune response towards activation of lymphocytes, with predominance of cellular immune reactions. As a rule, it results in remodeling of the vascular wall under participation of proinflammatory cytokines, shifting blood lipid balance towards atherogenicity, destabilization of atherosclerotic plaque, development of thrombosis and acute coronary syndrome. In this respect, the aim of our work was to develop treatment methods that allow, under participation of endogenous immune regulators, to change the structure of pro-atherogenic links via their interactions at the initial stages of the atherosclerotic lesion formation in chronic coronary heart disease and hypertension.To achieve this goal, 80 patients (men) were selected among the marine specialists of the ship crews serving in the Arctic latitudes and the Far North, with ischemic heart disease, stage 1 hypertension and astheno-neurotic disorders with anxiety and depressive manifestations. The groups of patients were formed as follows: Group 1 (n = 31, patients who received standard therapy with cardiotropic drugs; Group 2 (n = 29), subjects who underwent drug correction with weak tranquilizers as a part of standard cardiotropic therapy; Group 3 (n = 34), standard therapy accompanied by medical and psychological rehabilitation and digital psychophysiological therapy. Effectiveness of the treatment was studied by assessing the dynamics of parameters characterizing the neuropeptide-cytokine immune status, the markers used in the diagnostics of atherosclerosis, as well as paired relationships between them. The laboratory ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Medical Immunology (Russia) 23 3 541 556 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
Russian |
topic |
neuropeptide-cytokine status ischemic heart disease hypertension atherosclerosis anxiety-depressive disorders p-endorphin cytokines Immunologic diseases. Allergy RC581-607 |
spellingShingle |
neuropeptide-cytokine status ischemic heart disease hypertension atherosclerosis anxiety-depressive disorders p-endorphin cytokines Immunologic diseases. Allergy RC581-607 A. V. Gertsev Yu. N. Zakrevskii V. N. Ischuk Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North |
topic_facet |
neuropeptide-cytokine status ischemic heart disease hypertension atherosclerosis anxiety-depressive disorders p-endorphin cytokines Immunologic diseases. Allergy RC581-607 |
description |
Scientific medical literature has accumulated a lot of data suggesting most important components of coronary heart disease pathogenesis and hypertension to be complex triggering processes of neuro-immune and neuro-endocrine interactions. Risk factors for cardiovascular diseases at the initial stages of atherosclerosis formation cause endothelial dysfunction and trigger a cascade of immune inflammation in coronary vessels, which is based on shifting immune response towards activation of lymphocytes, with predominance of cellular immune reactions. As a rule, it results in remodeling of the vascular wall under participation of proinflammatory cytokines, shifting blood lipid balance towards atherogenicity, destabilization of atherosclerotic plaque, development of thrombosis and acute coronary syndrome. In this respect, the aim of our work was to develop treatment methods that allow, under participation of endogenous immune regulators, to change the structure of pro-atherogenic links via their interactions at the initial stages of the atherosclerotic lesion formation in chronic coronary heart disease and hypertension.To achieve this goal, 80 patients (men) were selected among the marine specialists of the ship crews serving in the Arctic latitudes and the Far North, with ischemic heart disease, stage 1 hypertension and astheno-neurotic disorders with anxiety and depressive manifestations. The groups of patients were formed as follows: Group 1 (n = 31, patients who received standard therapy with cardiotropic drugs; Group 2 (n = 29), subjects who underwent drug correction with weak tranquilizers as a part of standard cardiotropic therapy; Group 3 (n = 34), standard therapy accompanied by medical and psychological rehabilitation and digital psychophysiological therapy. Effectiveness of the treatment was studied by assessing the dynamics of parameters characterizing the neuropeptide-cytokine immune status, the markers used in the diagnostics of atherosclerosis, as well as paired relationships between them. The laboratory ... |
format |
Article in Journal/Newspaper |
author |
A. V. Gertsev Yu. N. Zakrevskii V. N. Ischuk |
author_facet |
A. V. Gertsev Yu. N. Zakrevskii V. N. Ischuk |
author_sort |
A. V. Gertsev |
title |
Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North |
title_short |
Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North |
title_full |
Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North |
title_fullStr |
Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North |
title_full_unstemmed |
Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North |
title_sort |
efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the far north |
publisher |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
publishDate |
2021 |
url |
https://doi.org/10.15789/1563-0625-EVF-2160 https://doaj.org/article/025ac9827a774657b13f648cb8f4bdad |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Медицинская иммунология, Vol 23, Iss 3, Pp 541-556 (2021) |
op_relation |
https://www.mimmun.ru/mimmun/article/view/2191 https://doaj.org/toc/1563-0625 https://doaj.org/toc/2313-741X 1563-0625 2313-741X doi:10.15789/1563-0625-EVF-2160 https://doaj.org/article/025ac9827a774657b13f648cb8f4bdad |
op_doi |
https://doi.org/10.15789/1563-0625-EVF-2160 |
container_title |
Medical Immunology (Russia) |
container_volume |
23 |
container_issue |
3 |
container_start_page |
541 |
op_container_end_page |
556 |
_version_ |
1809897568692338688 |