Antivenom reversal of biochemical alterations induced by black scorpion Heterometrus fastigiousus Couzijn venom in mice

• Published in: Journal of Venomous Animals and Toxins including Tropical Diseases
• Main Author: MK Chaubey
• Format: Article in Journal/Newspaper
• Language: English
• Published: SciELO 2009
• Subjects: venom; antivenom; envenomation; Heterometrus fastigiousus; serotherapy; Arctic medicine. Tropical medicine; RC955-962; Toxicology. Poisons; RA1190-1270; Zoology; QL1-991; Arctic; Sav’
• Online Access: https://doi.org/10.1590/S1678-91992009000200006; https://doaj.org/article/0202918c782c4ddd987d776e118191f5

In the present study, Heterometrus fastigiousus venom (HFV) was employed as antigen to produce species-specific scorpion antivenom (SAV) in albino mice (NIH) strain. To determine SAV efficacy, it was pre-incubated with 10 LD50 of HFV and then injected subcutaneously into mice. Subsequently, mortalit...