A polyvalent coral snake antivenom with broad neutralization capacity.
Coral snakes of the genus Micrurus have a high diversity and wide distribution in the Americas. Despite envenomings by these animals being uncommon, accidents are often severe and may result in death. Producing an antivenom to treat these envenomings has been challenging since coral snakes are diffi...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0007250 https://doaj.org/article/01f9aa8884cc4f3baf4614bf8d4ea4f1 |
id |
ftdoajarticles:oai:doaj.org/article:01f9aa8884cc4f3baf4614bf8d4ea4f1 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:01f9aa8884cc4f3baf4614bf8d4ea4f1 2023-05-15T15:02:33+02:00 A polyvalent coral snake antivenom with broad neutralization capacity. María Carlina Castillo-Beltrán Juan Pablo Hurtado-Gómez Vladimir Corredor-Espinel Francisco Javier Ruiz-Gómez 2019-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007250 https://doaj.org/article/01f9aa8884cc4f3baf4614bf8d4ea4f1 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007250 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007250 https://doaj.org/article/01f9aa8884cc4f3baf4614bf8d4ea4f1 PLoS Neglected Tropical Diseases, Vol 13, Iss 3, p e0007250 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007250 2022-12-31T07:36:44Z Coral snakes of the genus Micrurus have a high diversity and wide distribution in the Americas. Despite envenomings by these animals being uncommon, accidents are often severe and may result in death. Producing an antivenom to treat these envenomings has been challenging since coral snakes are difficult to catch, produce small amounts of venom, and the antivenoms produced have shown limited cross neutralization. Here we present data of cross neutralization among monovalent antivenoms raised against M. dumerilii, M. isozonus, M. mipartitus and M. surinamensis and the development of a new polyvalent coral snake antivenom, resulting from the mix of monovalent antivenoms. Our results, show that this coral snake antivenom has high neutralizing potency and wide taxonomic coverage, constituting a possible alternative for a long sought Pan-American coral snake antivenom. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 3 e0007250 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 María Carlina Castillo-Beltrán Juan Pablo Hurtado-Gómez Vladimir Corredor-Espinel Francisco Javier Ruiz-Gómez A polyvalent coral snake antivenom with broad neutralization capacity. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Coral snakes of the genus Micrurus have a high diversity and wide distribution in the Americas. Despite envenomings by these animals being uncommon, accidents are often severe and may result in death. Producing an antivenom to treat these envenomings has been challenging since coral snakes are difficult to catch, produce small amounts of venom, and the antivenoms produced have shown limited cross neutralization. Here we present data of cross neutralization among monovalent antivenoms raised against M. dumerilii, M. isozonus, M. mipartitus and M. surinamensis and the development of a new polyvalent coral snake antivenom, resulting from the mix of monovalent antivenoms. Our results, show that this coral snake antivenom has high neutralizing potency and wide taxonomic coverage, constituting a possible alternative for a long sought Pan-American coral snake antivenom. |
format |
Article in Journal/Newspaper |
author |
María Carlina Castillo-Beltrán Juan Pablo Hurtado-Gómez Vladimir Corredor-Espinel Francisco Javier Ruiz-Gómez |
author_facet |
María Carlina Castillo-Beltrán Juan Pablo Hurtado-Gómez Vladimir Corredor-Espinel Francisco Javier Ruiz-Gómez |
author_sort |
María Carlina Castillo-Beltrán |
title |
A polyvalent coral snake antivenom with broad neutralization capacity. |
title_short |
A polyvalent coral snake antivenom with broad neutralization capacity. |
title_full |
A polyvalent coral snake antivenom with broad neutralization capacity. |
title_fullStr |
A polyvalent coral snake antivenom with broad neutralization capacity. |
title_full_unstemmed |
A polyvalent coral snake antivenom with broad neutralization capacity. |
title_sort |
polyvalent coral snake antivenom with broad neutralization capacity. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007250 https://doaj.org/article/01f9aa8884cc4f3baf4614bf8d4ea4f1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 3, p e0007250 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007250 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007250 https://doaj.org/article/01f9aa8884cc4f3baf4614bf8d4ea4f1 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007250 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
3 |
container_start_page |
e0007250 |
_version_ |
1766334496026656768 |