Serological Evidence of Hepatitis E Virus Infection in Semi-Domesticated Eurasian Tundra Reindeer ( Rangifer tarandus tarandus ) in Norway
Hepatitis E virus (HEV) is a common cause of viral hepatitis in humans. In developing countries, HEV-infections seem to be mainly associated with pigs, but other animal species may be involved in viral transmission. Recently, anti-HEV antibodies were detected in Norwegian wild reindeer. Here, we inv...
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ftdoajarticles:oai:doaj.org/article:01f58076723d4ebf9bb8ca05cb1a1956 2023-05-15T18:04:22+02:00 Serological Evidence of Hepatitis E Virus Infection in Semi-Domesticated Eurasian Tundra Reindeer ( Rangifer tarandus tarandus ) in Norway Christine Hanssen Rinaldo Ingebjørg Helena Nymo Javier Sánchez Romano Eva Marie Breines Francisco Javier Ancin Murguzur Morten Tryland 2021-11-01T00:00:00Z https://doi.org/10.3390/pathogens10121542 https://doaj.org/article/01f58076723d4ebf9bb8ca05cb1a1956 EN eng MDPI AG https://www.mdpi.com/2076-0817/10/12/1542 https://doaj.org/toc/2076-0817 doi:10.3390/pathogens10121542 2076-0817 https://doaj.org/article/01f58076723d4ebf9bb8ca05cb1a1956 Pathogens, Vol 10, Iss 1542, p 1542 (2021) hepatitis E virus Hepeviridae Rangifer serology zoonosis Medicine R article 2021 ftdoajarticles https://doi.org/10.3390/pathogens10121542 2022-12-30T23:45:40Z Hepatitis E virus (HEV) is a common cause of viral hepatitis in humans. In developing countries, HEV-infections seem to be mainly associated with pigs, but other animal species may be involved in viral transmission. Recently, anti-HEV antibodies were detected in Norwegian wild reindeer. Here, we investigated anti-HEV seroprevalence in Norwegian semi-domesticated reindeer, animals in closer contact with humans than their wild counterparts. Blood samples (n = 516) were obtained from eight reindeer herds during the period 2013–2017 and analysed with a commercial enzyme-linked immunosorbent assay designed for detecting anti-HEV antibodies in livestock. Antibodies were found in all herds and for all sampling seasons. The overall seroprevalence was 15.7% (81/516), with adults showing a slightly higher seroprevalence (18.0%, 46/256) than calves (13.5%, 35/260, p = 0.11). The seroprevalence was not influenced by gender or latitude, and there was no temporal trend ( p > 0.15). A positive association between the presence of anti-HEV antibodies and antibodies against alphaherpesvirus and pestivirus, detected in a previous screening, was found ( p < 0.05). We conclude that Norwegian semi-domesticated reindeer are exposed to HEV or an antigenically similar virus. Whether the virus is affecting reindeer health or infects humans and poses a threat for human health remains unknown and warrants further investigations. Article in Journal/Newspaper Rangifer tarandus Tundra Directory of Open Access Journals: DOAJ Articles Norway Pathogens 10 12 1542 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
hepatitis E virus Hepeviridae Rangifer serology zoonosis Medicine R |
spellingShingle |
hepatitis E virus Hepeviridae Rangifer serology zoonosis Medicine R Christine Hanssen Rinaldo Ingebjørg Helena Nymo Javier Sánchez Romano Eva Marie Breines Francisco Javier Ancin Murguzur Morten Tryland Serological Evidence of Hepatitis E Virus Infection in Semi-Domesticated Eurasian Tundra Reindeer ( Rangifer tarandus tarandus ) in Norway |
topic_facet |
hepatitis E virus Hepeviridae Rangifer serology zoonosis Medicine R |
description |
Hepatitis E virus (HEV) is a common cause of viral hepatitis in humans. In developing countries, HEV-infections seem to be mainly associated with pigs, but other animal species may be involved in viral transmission. Recently, anti-HEV antibodies were detected in Norwegian wild reindeer. Here, we investigated anti-HEV seroprevalence in Norwegian semi-domesticated reindeer, animals in closer contact with humans than their wild counterparts. Blood samples (n = 516) were obtained from eight reindeer herds during the period 2013–2017 and analysed with a commercial enzyme-linked immunosorbent assay designed for detecting anti-HEV antibodies in livestock. Antibodies were found in all herds and for all sampling seasons. The overall seroprevalence was 15.7% (81/516), with adults showing a slightly higher seroprevalence (18.0%, 46/256) than calves (13.5%, 35/260, p = 0.11). The seroprevalence was not influenced by gender or latitude, and there was no temporal trend ( p > 0.15). A positive association between the presence of anti-HEV antibodies and antibodies against alphaherpesvirus and pestivirus, detected in a previous screening, was found ( p < 0.05). We conclude that Norwegian semi-domesticated reindeer are exposed to HEV or an antigenically similar virus. Whether the virus is affecting reindeer health or infects humans and poses a threat for human health remains unknown and warrants further investigations. |
format |
Article in Journal/Newspaper |
author |
Christine Hanssen Rinaldo Ingebjørg Helena Nymo Javier Sánchez Romano Eva Marie Breines Francisco Javier Ancin Murguzur Morten Tryland |
author_facet |
Christine Hanssen Rinaldo Ingebjørg Helena Nymo Javier Sánchez Romano Eva Marie Breines Francisco Javier Ancin Murguzur Morten Tryland |
author_sort |
Christine Hanssen Rinaldo |
title |
Serological Evidence of Hepatitis E Virus Infection in Semi-Domesticated Eurasian Tundra Reindeer ( Rangifer tarandus tarandus ) in Norway |
title_short |
Serological Evidence of Hepatitis E Virus Infection in Semi-Domesticated Eurasian Tundra Reindeer ( Rangifer tarandus tarandus ) in Norway |
title_full |
Serological Evidence of Hepatitis E Virus Infection in Semi-Domesticated Eurasian Tundra Reindeer ( Rangifer tarandus tarandus ) in Norway |
title_fullStr |
Serological Evidence of Hepatitis E Virus Infection in Semi-Domesticated Eurasian Tundra Reindeer ( Rangifer tarandus tarandus ) in Norway |
title_full_unstemmed |
Serological Evidence of Hepatitis E Virus Infection in Semi-Domesticated Eurasian Tundra Reindeer ( Rangifer tarandus tarandus ) in Norway |
title_sort |
serological evidence of hepatitis e virus infection in semi-domesticated eurasian tundra reindeer ( rangifer tarandus tarandus ) in norway |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doi.org/10.3390/pathogens10121542 https://doaj.org/article/01f58076723d4ebf9bb8ca05cb1a1956 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Rangifer tarandus Tundra |
genre_facet |
Rangifer tarandus Tundra |
op_source |
Pathogens, Vol 10, Iss 1542, p 1542 (2021) |
op_relation |
https://www.mdpi.com/2076-0817/10/12/1542 https://doaj.org/toc/2076-0817 doi:10.3390/pathogens10121542 2076-0817 https://doaj.org/article/01f58076723d4ebf9bb8ca05cb1a1956 |
op_doi |
https://doi.org/10.3390/pathogens10121542 |
container_title |
Pathogens |
container_volume |
10 |
container_issue |
12 |
container_start_page |
1542 |
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1766175731142885376 |