Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy)
ABSTRACT Involvement of the digestive system in AIDS pathologies or injuries is frequent. Aiming at comparing the frequency, the importance that these lesions have for death and the survival time in patients using or not using HAART, we studied 322 necropsies classified as follows: Group A - without...
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ftdoajarticles:oai:doaj.org/article:01d78935de6e480bb6db261c334866d2 2024-09-09T19:26:53+00:00 Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy) Lucinda Calheiros Guimarães Ana Cristina Araújo Lemos da Silva Adilha Misson Rua Micheletti Everton Nunes Melo Moura Mario Léon Silva-Vergara Sebastião Tostes Júnior Sheila Jorge Adad https://doi.org/10.1590/s1678-9946201759003 https://doaj.org/article/01d78935de6e480bb6db261c334866d2 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652017005000201&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946201759003 https://doaj.org/article/01d78935de6e480bb6db261c334866d2 Revista do Instituto de Medicina Tropical de São Paulo, Vol 59, Iss 0 Autopsy Necropsy AIDS Digestive system HAART Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article ftdoajarticles https://doi.org/10.1590/s1678-9946201759003 2024-08-05T17:49:31Z ABSTRACT Involvement of the digestive system in AIDS pathologies or injuries is frequent. Aiming at comparing the frequency, the importance that these lesions have for death and the survival time in patients using or not using HAART, we studied 322 necropsies classified as follows: Group A - without antiretroviral drugs (185 cases); B - one or two antiretroviral drugs or HAART for less than six months (83 cases); C - HAART for six months or longer (54 cases). In the overall analysis of the digestive system, changes were present in 73.6% of cases. The most frequent was Candida infection (22.7%), followed by cytomegalovirus (19.2%), Histoplasma capsulatum (6.5%), mycobacteria (5.6%), and Toxoplasma gondii (4.3%). T. gondii infection was more frequent in group A compared with group C, and cytomegalovirus (CMV) was more frequent in group A compared with groups B and C (p < 0.05); 2.2% of the deaths were due to gastrointestinal bleeding. Regarding the segments, only in the large intestine, and only cytomegalovirus, were more frequent in group A compared with group C. We conclude that digestive system infections are still frequent, even with the use of HAART. However, the average survival time in group C was more than three times greater than the one in group A and nearly double that of group B, demonstrating the clear benefit of this therapy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 59 0 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Autopsy Necropsy AIDS Digestive system HAART Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Autopsy Necropsy AIDS Digestive system HAART Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Lucinda Calheiros Guimarães Ana Cristina Araújo Lemos da Silva Adilha Misson Rua Micheletti Everton Nunes Melo Moura Mario Léon Silva-Vergara Sebastião Tostes Júnior Sheila Jorge Adad Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy) |
topic_facet |
Autopsy Necropsy AIDS Digestive system HAART Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
ABSTRACT Involvement of the digestive system in AIDS pathologies or injuries is frequent. Aiming at comparing the frequency, the importance that these lesions have for death and the survival time in patients using or not using HAART, we studied 322 necropsies classified as follows: Group A - without antiretroviral drugs (185 cases); B - one or two antiretroviral drugs or HAART for less than six months (83 cases); C - HAART for six months or longer (54 cases). In the overall analysis of the digestive system, changes were present in 73.6% of cases. The most frequent was Candida infection (22.7%), followed by cytomegalovirus (19.2%), Histoplasma capsulatum (6.5%), mycobacteria (5.6%), and Toxoplasma gondii (4.3%). T. gondii infection was more frequent in group A compared with group C, and cytomegalovirus (CMV) was more frequent in group A compared with groups B and C (p < 0.05); 2.2% of the deaths were due to gastrointestinal bleeding. Regarding the segments, only in the large intestine, and only cytomegalovirus, were more frequent in group A compared with group C. We conclude that digestive system infections are still frequent, even with the use of HAART. However, the average survival time in group C was more than three times greater than the one in group A and nearly double that of group B, demonstrating the clear benefit of this therapy. |
format |
Article in Journal/Newspaper |
author |
Lucinda Calheiros Guimarães Ana Cristina Araújo Lemos da Silva Adilha Misson Rua Micheletti Everton Nunes Melo Moura Mario Léon Silva-Vergara Sebastião Tostes Júnior Sheila Jorge Adad |
author_facet |
Lucinda Calheiros Guimarães Ana Cristina Araújo Lemos da Silva Adilha Misson Rua Micheletti Everton Nunes Melo Moura Mario Léon Silva-Vergara Sebastião Tostes Júnior Sheila Jorge Adad |
author_sort |
Lucinda Calheiros Guimarães |
title |
Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy) |
title_short |
Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy) |
title_full |
Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy) |
title_fullStr |
Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy) |
title_full_unstemmed |
Morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-HAART (Highly Active Antiretroviral Therapy) |
title_sort |
morphological changes in the digestive system of 322 necropsies of patients with acquired immune deficiency syndrome: comparison of findings pre- and post-haart (highly active antiretroviral therapy) |
publisher |
Universidade de São Paulo (USP) |
url |
https://doi.org/10.1590/s1678-9946201759003 https://doaj.org/article/01d78935de6e480bb6db261c334866d2 |
geographic |
Arctic |
geographic_facet |
Arctic |
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Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 59, Iss 0 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652017005000201&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946201759003 https://doaj.org/article/01d78935de6e480bb6db261c334866d2 |
op_doi |
https://doi.org/10.1590/s1678-9946201759003 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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59 |
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