Feasible introgression of an anti-pathogen transgene into an urban mosquito population without using gene-drive.
Introgressing anti-pathogen constructs into wild vector populations could reduce disease transmission. It is generally assumed that such introgression would require linking an anti-pathogen gene with a selfish genetic element or similar technologies. Yet none of the proposed transgenic anti-pathogen...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0002827 https://doaj.org/article/018fd28e3f7c4d60960cfdbe1a85bc3b |
id |
ftdoajarticles:oai:doaj.org/article:018fd28e3f7c4d60960cfdbe1a85bc3b |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:018fd28e3f7c4d60960cfdbe1a85bc3b 2023-05-15T15:16:52+02:00 Feasible introgression of an anti-pathogen transgene into an urban mosquito population without using gene-drive. Kenichi W Okamoto Michael A Robert Fred Gould Alun L Lloyd 2014-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002827 https://doaj.org/article/018fd28e3f7c4d60960cfdbe1a85bc3b EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4081001?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002827 https://doaj.org/article/018fd28e3f7c4d60960cfdbe1a85bc3b PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e2827 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002827 2022-12-30T21:57:33Z Introgressing anti-pathogen constructs into wild vector populations could reduce disease transmission. It is generally assumed that such introgression would require linking an anti-pathogen gene with a selfish genetic element or similar technologies. Yet none of the proposed transgenic anti-pathogen gene-drive mechanisms are likely to be implemented as public health measures in the near future. Thus, much attention now focuses instead on transgenic strategies aimed at mosquito population suppression, an approach generally perceived to be practical. By contrast, aiming to replace vector competent mosquito populations with vector incompetent populations by releasing mosquitoes carrying a single anti-pathogen gene without a gene-drive mechanism is widely considered impractical.Here we use Skeeter Buster, a previously published stochastic, spatially explicit model of Aedes aegypti to investigate whether a number of approaches for releasing mosquitoes with only an anti-pathogen construct would be efficient and effective in the tropical city of Iquitos, Peru. To assess the performance of such releases using realistic release numbers, we compare the transient and long-term effects of this strategy with two other genetic control strategies that have been developed in Ae. aegypti: release of a strain with female-specific lethality, and a strain with both female-specific lethality and an anti-pathogen gene. We find that releasing mosquitoes carrying only an anti-pathogen construct can substantially decrease vector competence of a natural population, even at release ratios well below that required for the two currently feasible alternatives that rely on population reduction. Finally, although current genetic control strategies based on population reduction are compromised by immigration of wild-type mosquitoes, releasing mosquitoes carrying only an anti-pathogen gene is considerably more robust to such immigration.Contrary to the widely held view that transgenic control programs aimed at population replacement require ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 7 e2827 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Kenichi W Okamoto Michael A Robert Fred Gould Alun L Lloyd Feasible introgression of an anti-pathogen transgene into an urban mosquito population without using gene-drive. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Introgressing anti-pathogen constructs into wild vector populations could reduce disease transmission. It is generally assumed that such introgression would require linking an anti-pathogen gene with a selfish genetic element or similar technologies. Yet none of the proposed transgenic anti-pathogen gene-drive mechanisms are likely to be implemented as public health measures in the near future. Thus, much attention now focuses instead on transgenic strategies aimed at mosquito population suppression, an approach generally perceived to be practical. By contrast, aiming to replace vector competent mosquito populations with vector incompetent populations by releasing mosquitoes carrying a single anti-pathogen gene without a gene-drive mechanism is widely considered impractical.Here we use Skeeter Buster, a previously published stochastic, spatially explicit model of Aedes aegypti to investigate whether a number of approaches for releasing mosquitoes with only an anti-pathogen construct would be efficient and effective in the tropical city of Iquitos, Peru. To assess the performance of such releases using realistic release numbers, we compare the transient and long-term effects of this strategy with two other genetic control strategies that have been developed in Ae. aegypti: release of a strain with female-specific lethality, and a strain with both female-specific lethality and an anti-pathogen gene. We find that releasing mosquitoes carrying only an anti-pathogen construct can substantially decrease vector competence of a natural population, even at release ratios well below that required for the two currently feasible alternatives that rely on population reduction. Finally, although current genetic control strategies based on population reduction are compromised by immigration of wild-type mosquitoes, releasing mosquitoes carrying only an anti-pathogen gene is considerably more robust to such immigration.Contrary to the widely held view that transgenic control programs aimed at population replacement require ... |
format |
Article in Journal/Newspaper |
author |
Kenichi W Okamoto Michael A Robert Fred Gould Alun L Lloyd |
author_facet |
Kenichi W Okamoto Michael A Robert Fred Gould Alun L Lloyd |
author_sort |
Kenichi W Okamoto |
title |
Feasible introgression of an anti-pathogen transgene into an urban mosquito population without using gene-drive. |
title_short |
Feasible introgression of an anti-pathogen transgene into an urban mosquito population without using gene-drive. |
title_full |
Feasible introgression of an anti-pathogen transgene into an urban mosquito population without using gene-drive. |
title_fullStr |
Feasible introgression of an anti-pathogen transgene into an urban mosquito population without using gene-drive. |
title_full_unstemmed |
Feasible introgression of an anti-pathogen transgene into an urban mosquito population without using gene-drive. |
title_sort |
feasible introgression of an anti-pathogen transgene into an urban mosquito population without using gene-drive. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0002827 https://doaj.org/article/018fd28e3f7c4d60960cfdbe1a85bc3b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e2827 (2014) |
op_relation |
http://europepmc.org/articles/PMC4081001?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002827 https://doaj.org/article/018fd28e3f7c4d60960cfdbe1a85bc3b |
op_doi |
https://doi.org/10.1371/journal.pntd.0002827 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
8 |
container_issue |
7 |
container_start_page |
e2827 |
_version_ |
1766347166341660672 |