A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy
Abstract Background Malaria chemoprophylaxis options in pregnancy are limited, and atovaquone–proguanil (AP) is not recommended because of insufficient safety evidence. An anonymous, internet-based survey was disseminated to describe outcomes of pregnancies accidentally exposed to AP. Outcomes of in...
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ftdoajarticles:oai:doaj.org/article:015c150366bb4a128418116f3f2f1b63 2023-05-15T15:06:39+02:00 A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy Kathrine R. Tan Jessica K. Fairley Mengxi Wang Julie R. Gutman 2018-05-01T00:00:00Z https://doi.org/10.1186/s12936-018-2352-z https://doaj.org/article/015c150366bb4a128418116f3f2f1b63 EN eng BMC http://link.springer.com/article/10.1186/s12936-018-2352-z https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2352-z 1475-2875 https://doaj.org/article/015c150366bb4a128418116f3f2f1b63 Malaria Journal, Vol 17, Iss 1, Pp 1-4 (2018) Malaria Pregnancy Prophylaxis Atovaquone–proguanil Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12936-018-2352-z 2022-12-31T04:15:47Z Abstract Background Malaria chemoprophylaxis options in pregnancy are limited, and atovaquone–proguanil (AP) is not recommended because of insufficient safety evidence. An anonymous, internet-based survey was disseminated to describe outcomes of pregnancies accidentally exposed to AP. Outcomes of interest included miscarriage (defined as pregnancy loss before 20 weeks), stillbirth (defined as pregnancy loss at or after 20 weeks), preterm birth or live birth prior to 37 weeks, and the presence of congenital anomalies. Results A total of 487 women responded and reported on 822 pregnancies. Of the 807 pregnancies with information available on exposure and outcomes, 10 (1.2%) had atovaquone–proguanil exposure, all in the first trimester, and all resulted in term births with no birth defects. Conclusions Use of an anti-malarial not recommended in pregnancy is likely to occur before the woman knows of her pregnancy. This study adds to the limited evidence of the safety of AP in pregnancy. Further study on use of AP in pregnancy should be a high priority, as an alternative option for the prevention of malaria in pregnancy in non-immune travellers is urgently needed. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 17 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Malaria Pregnancy Prophylaxis Atovaquone–proguanil Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Pregnancy Prophylaxis Atovaquone–proguanil Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Kathrine R. Tan Jessica K. Fairley Mengxi Wang Julie R. Gutman A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy |
topic_facet |
Malaria Pregnancy Prophylaxis Atovaquone–proguanil Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria chemoprophylaxis options in pregnancy are limited, and atovaquone–proguanil (AP) is not recommended because of insufficient safety evidence. An anonymous, internet-based survey was disseminated to describe outcomes of pregnancies accidentally exposed to AP. Outcomes of interest included miscarriage (defined as pregnancy loss before 20 weeks), stillbirth (defined as pregnancy loss at or after 20 weeks), preterm birth or live birth prior to 37 weeks, and the presence of congenital anomalies. Results A total of 487 women responded and reported on 822 pregnancies. Of the 807 pregnancies with information available on exposure and outcomes, 10 (1.2%) had atovaquone–proguanil exposure, all in the first trimester, and all resulted in term births with no birth defects. Conclusions Use of an anti-malarial not recommended in pregnancy is likely to occur before the woman knows of her pregnancy. This study adds to the limited evidence of the safety of AP in pregnancy. Further study on use of AP in pregnancy should be a high priority, as an alternative option for the prevention of malaria in pregnancy in non-immune travellers is urgently needed. |
format |
Article in Journal/Newspaper |
author |
Kathrine R. Tan Jessica K. Fairley Mengxi Wang Julie R. Gutman |
author_facet |
Kathrine R. Tan Jessica K. Fairley Mengxi Wang Julie R. Gutman |
author_sort |
Kathrine R. Tan |
title |
A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy |
title_short |
A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy |
title_full |
A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy |
title_fullStr |
A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy |
title_full_unstemmed |
A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy |
title_sort |
survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12936-018-2352-z https://doaj.org/article/015c150366bb4a128418116f3f2f1b63 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 17, Iss 1, Pp 1-4 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12936-018-2352-z https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2352-z 1475-2875 https://doaj.org/article/015c150366bb4a128418116f3f2f1b63 |
op_doi |
https://doi.org/10.1186/s12936-018-2352-z |
container_title |
Malaria Journal |
container_volume |
17 |
container_issue |
1 |
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1766338210757083136 |