The past, current and future trends in DNA vaccine immunisations
This review focuses on DNA vaccines, denoting the last two decades since the early substantiation of preclinical protection was published in Science in 1993 by Ulmer et al. In spite of being safely administered and easily engineered and manufactured DNA vaccine, it holds the future prospects of immu...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2015
|
Subjects: | |
Online Access: | https://doi.org/10.1016/S2221-1691(15)30366-X https://doaj.org/article/01466f7a0f394dcab8c263e6f7f38bca |
id |
ftdoajarticles:oai:doaj.org/article:01466f7a0f394dcab8c263e6f7f38bca |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:01466f7a0f394dcab8c263e6f7f38bca 2023-05-15T15:08:33+02:00 The past, current and future trends in DNA vaccine immunisations Sidgi Syed Anwer Abdo Hasson Juma Khalifa Zayid Al-Busaidi Talal Abdulmalek Sallam 2015-05-01T00:00:00Z https://doi.org/10.1016/S2221-1691(15)30366-X https://doaj.org/article/01466f7a0f394dcab8c263e6f7f38bca EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S222116911530366X https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/S2221-1691(15)30366-X https://doaj.org/article/01466f7a0f394dcab8c263e6f7f38bca Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 5, Pp 344-353 (2015) Plasmid DNA Clinical trials Vaccine Bioechnology Immunotherapy Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2015 ftdoajarticles https://doi.org/10.1016/S2221-1691(15)30366-X 2022-12-31T01:17:52Z This review focuses on DNA vaccines, denoting the last two decades since the early substantiation of preclinical protection was published in Science in 1993 by Ulmer et al. In spite of being safely administered and easily engineered and manufactured DNA vaccine, it holds the future prospects of immunization by inducing potent cellular immune responses against infectious and non-infectious diseases. It is well documented that injection of DNA plasmid encoding a desired gene of interest can result in the subsequent expression of its products and lead to the induction of an immune response within a host. This is pertinent to prophylactic and therapeutic vaccination approach when the peculiar gene produces a protective epitope from a pathogen. The recent studies demonstrated by a number of research centers showed that these immune responses evoke protective immunity against several infectious diseases and cancers, which provides adequate support for the use of this approach. We attempt in this review to provide an informative and unbiased overview of the general principles and concept of DNA vaccines technology with a summary of a novel approach to the DNA vaccine, present investigations that describe the mechanism(s) of protective immunity provoked by DNA immunization and to highlight the advantages and disadvantages of DNA immunisation. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Ulmer ENVELOPE(-86.000,-86.000,-77.500,-77.500) Asian Pacific Journal of Tropical Biomedicine 5 5 344 353 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Plasmid DNA Clinical trials Vaccine Bioechnology Immunotherapy Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Plasmid DNA Clinical trials Vaccine Bioechnology Immunotherapy Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Sidgi Syed Anwer Abdo Hasson Juma Khalifa Zayid Al-Busaidi Talal Abdulmalek Sallam The past, current and future trends in DNA vaccine immunisations |
topic_facet |
Plasmid DNA Clinical trials Vaccine Bioechnology Immunotherapy Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
This review focuses on DNA vaccines, denoting the last two decades since the early substantiation of preclinical protection was published in Science in 1993 by Ulmer et al. In spite of being safely administered and easily engineered and manufactured DNA vaccine, it holds the future prospects of immunization by inducing potent cellular immune responses against infectious and non-infectious diseases. It is well documented that injection of DNA plasmid encoding a desired gene of interest can result in the subsequent expression of its products and lead to the induction of an immune response within a host. This is pertinent to prophylactic and therapeutic vaccination approach when the peculiar gene produces a protective epitope from a pathogen. The recent studies demonstrated by a number of research centers showed that these immune responses evoke protective immunity against several infectious diseases and cancers, which provides adequate support for the use of this approach. We attempt in this review to provide an informative and unbiased overview of the general principles and concept of DNA vaccines technology with a summary of a novel approach to the DNA vaccine, present investigations that describe the mechanism(s) of protective immunity provoked by DNA immunization and to highlight the advantages and disadvantages of DNA immunisation. |
format |
Article in Journal/Newspaper |
author |
Sidgi Syed Anwer Abdo Hasson Juma Khalifa Zayid Al-Busaidi Talal Abdulmalek Sallam |
author_facet |
Sidgi Syed Anwer Abdo Hasson Juma Khalifa Zayid Al-Busaidi Talal Abdulmalek Sallam |
author_sort |
Sidgi Syed Anwer Abdo Hasson |
title |
The past, current and future trends in DNA vaccine immunisations |
title_short |
The past, current and future trends in DNA vaccine immunisations |
title_full |
The past, current and future trends in DNA vaccine immunisations |
title_fullStr |
The past, current and future trends in DNA vaccine immunisations |
title_full_unstemmed |
The past, current and future trends in DNA vaccine immunisations |
title_sort |
past, current and future trends in dna vaccine immunisations |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2015 |
url |
https://doi.org/10.1016/S2221-1691(15)30366-X https://doaj.org/article/01466f7a0f394dcab8c263e6f7f38bca |
long_lat |
ENVELOPE(-86.000,-86.000,-77.500,-77.500) |
geographic |
Arctic Ulmer |
geographic_facet |
Arctic Ulmer |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 5, Pp 344-353 (2015) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S222116911530366X https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/S2221-1691(15)30366-X https://doaj.org/article/01466f7a0f394dcab8c263e6f7f38bca |
op_doi |
https://doi.org/10.1016/S2221-1691(15)30366-X |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
5 |
container_issue |
5 |
container_start_page |
344 |
op_container_end_page |
353 |
_version_ |
1766339890562203648 |