YG-1 Extract Improves Acute Pulmonary Inflammation by Inducing Bronchodilation and Inhibiting Inflammatory Cytokines
YG-1 extract used in this study is a mixture of Lonicera japonica , Arctic Fructus , and Scutellariae Radix . The present study was designed to investigate the effect of YG-1 extract on bronchodilatation (ex vivo) and acute bronchial and pulmonary inflammation relief (in vivo). Ex vivo: The bronchod...
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ftdoajarticles:oai:doaj.org/article:013771c95dba4f09806111843798c522 2023-05-15T15:16:20+02:00 YG-1 Extract Improves Acute Pulmonary Inflammation by Inducing Bronchodilation and Inhibiting Inflammatory Cytokines Hye-Yoom Kim Jung-Joo Yoon Dae-Sung Kim Dae-Gill Kang Ho-Sub Lee 2021-09-01T00:00:00Z https://doi.org/10.3390/nu13103414 https://doaj.org/article/013771c95dba4f09806111843798c522 EN eng MDPI AG https://www.mdpi.com/2072-6643/13/10/3414 https://doaj.org/toc/2072-6643 doi:10.3390/nu13103414 2072-6643 https://doaj.org/article/013771c95dba4f09806111843798c522 Nutrients, Vol 13, Iss 3414, p 3414 (2021) YG-1 extract bronchodilation fine particulate matter (PM2.5) acute lung injury airway inflammation Nutrition. Foods and food supply TX341-641 article 2021 ftdoajarticles https://doi.org/10.3390/nu13103414 2022-12-31T11:01:45Z YG-1 extract used in this study is a mixture of Lonicera japonica , Arctic Fructus , and Scutellariae Radix . The present study was designed to investigate the effect of YG-1 extract on bronchodilatation (ex vivo) and acute bronchial and pulmonary inflammation relief (in vivo). Ex vivo: The bronchodilation reaction was confirmed by treatment with YG-1 concentration-accumulation (0.01, 0.03, 0.1, 0.3, and 1 mg/mL) in the bronchial tissue ring pre-contracted by acetylcholine (10 μM). As a result, YG-1 extract is considered to affect bronchodilation by increased cyclic adenosine monophosphate, cAMP) levels through the β2-adrenergic receptor. In vivo: experiments were performed in C57BL/6 mice were divided into the following groups: control group; PM2.5 (fine particulate matter)-exposed group (PM2.5, 200 μg/kg/mL saline); and PM2.5-exposed + YG-1 extract (200 mg/kg/day) group. The PM2.5 (200 μg/kg/mL saline) was exposed for 1 h for 5 days using an ultrasonic nebulizer aerosol chamber to instill fine dust in the bronchi and lungs, thereby inducing acute lung and bronchial inflammation. From two days before PM2.5 exposure, YG-1 extract (200 mg/kg/day) was administered orally for 7 days. The PM2.5 exposure was involved in airway remodeling and inflammation, suggesting that YG-1 treatment improves acute bronchial and pulmonary inflammation by inhibiting the inflammatory cytokines (NLRP3/caspase-1 pathway). The application of YG-1 extract with broncho-dilating effect to acute bronchial and pulmonary inflammation animal models has great significance in developing therapeutic agents for respiratory diseases. Therefore, these results can provide essential data for the development of novel respiratory symptom relievers. Our study provides strong evidence that YG-1 extracts reduce the prevalence of respiratory symptoms and the incidence of non-specific lung diseases and improve bronchial and lung function. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Nutrients 13 10 3414 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
YG-1 extract bronchodilation fine particulate matter (PM2.5) acute lung injury airway inflammation Nutrition. Foods and food supply TX341-641 |
spellingShingle |
YG-1 extract bronchodilation fine particulate matter (PM2.5) acute lung injury airway inflammation Nutrition. Foods and food supply TX341-641 Hye-Yoom Kim Jung-Joo Yoon Dae-Sung Kim Dae-Gill Kang Ho-Sub Lee YG-1 Extract Improves Acute Pulmonary Inflammation by Inducing Bronchodilation and Inhibiting Inflammatory Cytokines |
topic_facet |
YG-1 extract bronchodilation fine particulate matter (PM2.5) acute lung injury airway inflammation Nutrition. Foods and food supply TX341-641 |
description |
YG-1 extract used in this study is a mixture of Lonicera japonica , Arctic Fructus , and Scutellariae Radix . The present study was designed to investigate the effect of YG-1 extract on bronchodilatation (ex vivo) and acute bronchial and pulmonary inflammation relief (in vivo). Ex vivo: The bronchodilation reaction was confirmed by treatment with YG-1 concentration-accumulation (0.01, 0.03, 0.1, 0.3, and 1 mg/mL) in the bronchial tissue ring pre-contracted by acetylcholine (10 μM). As a result, YG-1 extract is considered to affect bronchodilation by increased cyclic adenosine monophosphate, cAMP) levels through the β2-adrenergic receptor. In vivo: experiments were performed in C57BL/6 mice were divided into the following groups: control group; PM2.5 (fine particulate matter)-exposed group (PM2.5, 200 μg/kg/mL saline); and PM2.5-exposed + YG-1 extract (200 mg/kg/day) group. The PM2.5 (200 μg/kg/mL saline) was exposed for 1 h for 5 days using an ultrasonic nebulizer aerosol chamber to instill fine dust in the bronchi and lungs, thereby inducing acute lung and bronchial inflammation. From two days before PM2.5 exposure, YG-1 extract (200 mg/kg/day) was administered orally for 7 days. The PM2.5 exposure was involved in airway remodeling and inflammation, suggesting that YG-1 treatment improves acute bronchial and pulmonary inflammation by inhibiting the inflammatory cytokines (NLRP3/caspase-1 pathway). The application of YG-1 extract with broncho-dilating effect to acute bronchial and pulmonary inflammation animal models has great significance in developing therapeutic agents for respiratory diseases. Therefore, these results can provide essential data for the development of novel respiratory symptom relievers. Our study provides strong evidence that YG-1 extracts reduce the prevalence of respiratory symptoms and the incidence of non-specific lung diseases and improve bronchial and lung function. |
format |
Article in Journal/Newspaper |
author |
Hye-Yoom Kim Jung-Joo Yoon Dae-Sung Kim Dae-Gill Kang Ho-Sub Lee |
author_facet |
Hye-Yoom Kim Jung-Joo Yoon Dae-Sung Kim Dae-Gill Kang Ho-Sub Lee |
author_sort |
Hye-Yoom Kim |
title |
YG-1 Extract Improves Acute Pulmonary Inflammation by Inducing Bronchodilation and Inhibiting Inflammatory Cytokines |
title_short |
YG-1 Extract Improves Acute Pulmonary Inflammation by Inducing Bronchodilation and Inhibiting Inflammatory Cytokines |
title_full |
YG-1 Extract Improves Acute Pulmonary Inflammation by Inducing Bronchodilation and Inhibiting Inflammatory Cytokines |
title_fullStr |
YG-1 Extract Improves Acute Pulmonary Inflammation by Inducing Bronchodilation and Inhibiting Inflammatory Cytokines |
title_full_unstemmed |
YG-1 Extract Improves Acute Pulmonary Inflammation by Inducing Bronchodilation and Inhibiting Inflammatory Cytokines |
title_sort |
yg-1 extract improves acute pulmonary inflammation by inducing bronchodilation and inhibiting inflammatory cytokines |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doi.org/10.3390/nu13103414 https://doaj.org/article/013771c95dba4f09806111843798c522 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Nutrients, Vol 13, Iss 3414, p 3414 (2021) |
op_relation |
https://www.mdpi.com/2072-6643/13/10/3414 https://doaj.org/toc/2072-6643 doi:10.3390/nu13103414 2072-6643 https://doaj.org/article/013771c95dba4f09806111843798c522 |
op_doi |
https://doi.org/10.3390/nu13103414 |
container_title |
Nutrients |
container_volume |
13 |
container_issue |
10 |
container_start_page |
3414 |
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1766346624463798272 |