Anti-lipogenic effect of Senna alata leaf extract in high-fat diet-induced obese mice
Objective: To examine the effect of Senna alata (S. alata) leaf extracts on the regulation of lipid metabolism in high-fat diet-induced obese mice. Methods: The obesity condition was induced in the male ICR mice by feeding them with high-fat diet (45 kcal% fat) for 12 weeks. At the 7th week of diet...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:00ddc003a63e445580ea3346be1ee816 2023-05-15T15:16:13+02:00 Anti-lipogenic effect of Senna alata leaf extract in high-fat diet-induced obese mice Jarinyaporn Naowaboot Supaporn Wannasiri 2016-03-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2015.12.006 https://doaj.org/article/00ddc003a63e445580ea3346be1ee816 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115308728 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.12.006 https://doaj.org/article/00ddc003a63e445580ea3346be1ee816 Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 3, Pp 232-238 (2016) Senna alata Obesity Insulin resistance Dyslipidemia Lipogenesis Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2016 ftdoajarticles https://doi.org/10.1016/j.apjtb.2015.12.006 2022-12-31T14:24:19Z Objective: To examine the effect of Senna alata (S. alata) leaf extracts on the regulation of lipid metabolism in high-fat diet-induced obese mice. Methods: The obesity condition was induced in the male ICR mice by feeding them with high-fat diet (45 kcal% fat) for 12 weeks. At the 7th week of diet feeding, the obese mice were treated with the water extract of S. alata leaf at 250 and 500 mg/kg/day, respectively, that continued for six weeks. At the end of the treatment period, the biochemical parameters were determined. The hepatic histology and the gene and protein expressions were also examined. Results: In comparison with the obese control mice, the mice treated with S. alata showed a significant reduction in the elevated blood glucose levels and a decrease in the serum insulin and leptin levels. A reduction in the serum total cholesterol, triglyceride, non-esterified fatty acid, and hepatic triglyceride levels were also observed. The histological examination of the obese mice treated with S. alata showed a reduced lipid accumulation in the liver tissue. Hepatic lipogenic gene expression showed that S. alata decreased the activity of sterol regulatory element binding protein 1c, fatty acid synthase, and acetyl-CoA carboxylase. S. alata could suppress hepatic peroxisome proliferator-activated receptor gamma (PPARγ) protein. Moreover, the protein expression of PPARα in liver tissue was clearly increased by S. alata treatment. Conclusion: The treatment with S. alata could decrease several parameters of impaired lipid metabolism in the obese mice by downregulating sterol regulatory element binding protein 1c and PPARγ and upregulating PPARα. This study is the first report on the role of S. alata leaf extract in alleviating the abnormal lipid metabolism in obese conditions. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 6 3 232 238 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Senna alata Obesity Insulin resistance Dyslipidemia Lipogenesis Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Senna alata Obesity Insulin resistance Dyslipidemia Lipogenesis Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Jarinyaporn Naowaboot Supaporn Wannasiri Anti-lipogenic effect of Senna alata leaf extract in high-fat diet-induced obese mice |
topic_facet |
Senna alata Obesity Insulin resistance Dyslipidemia Lipogenesis Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To examine the effect of Senna alata (S. alata) leaf extracts on the regulation of lipid metabolism in high-fat diet-induced obese mice. Methods: The obesity condition was induced in the male ICR mice by feeding them with high-fat diet (45 kcal% fat) for 12 weeks. At the 7th week of diet feeding, the obese mice were treated with the water extract of S. alata leaf at 250 and 500 mg/kg/day, respectively, that continued for six weeks. At the end of the treatment period, the biochemical parameters were determined. The hepatic histology and the gene and protein expressions were also examined. Results: In comparison with the obese control mice, the mice treated with S. alata showed a significant reduction in the elevated blood glucose levels and a decrease in the serum insulin and leptin levels. A reduction in the serum total cholesterol, triglyceride, non-esterified fatty acid, and hepatic triglyceride levels were also observed. The histological examination of the obese mice treated with S. alata showed a reduced lipid accumulation in the liver tissue. Hepatic lipogenic gene expression showed that S. alata decreased the activity of sterol regulatory element binding protein 1c, fatty acid synthase, and acetyl-CoA carboxylase. S. alata could suppress hepatic peroxisome proliferator-activated receptor gamma (PPARγ) protein. Moreover, the protein expression of PPARα in liver tissue was clearly increased by S. alata treatment. Conclusion: The treatment with S. alata could decrease several parameters of impaired lipid metabolism in the obese mice by downregulating sterol regulatory element binding protein 1c and PPARγ and upregulating PPARα. This study is the first report on the role of S. alata leaf extract in alleviating the abnormal lipid metabolism in obese conditions. |
format |
Article in Journal/Newspaper |
author |
Jarinyaporn Naowaboot Supaporn Wannasiri |
author_facet |
Jarinyaporn Naowaboot Supaporn Wannasiri |
author_sort |
Jarinyaporn Naowaboot |
title |
Anti-lipogenic effect of Senna alata leaf extract in high-fat diet-induced obese mice |
title_short |
Anti-lipogenic effect of Senna alata leaf extract in high-fat diet-induced obese mice |
title_full |
Anti-lipogenic effect of Senna alata leaf extract in high-fat diet-induced obese mice |
title_fullStr |
Anti-lipogenic effect of Senna alata leaf extract in high-fat diet-induced obese mice |
title_full_unstemmed |
Anti-lipogenic effect of Senna alata leaf extract in high-fat diet-induced obese mice |
title_sort |
anti-lipogenic effect of senna alata leaf extract in high-fat diet-induced obese mice |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2016 |
url |
https://doi.org/10.1016/j.apjtb.2015.12.006 https://doaj.org/article/00ddc003a63e445580ea3346be1ee816 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 3, Pp 232-238 (2016) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115308728 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.12.006 https://doaj.org/article/00ddc003a63e445580ea3346be1ee816 |
op_doi |
https://doi.org/10.1016/j.apjtb.2015.12.006 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
6 |
container_issue |
3 |
container_start_page |
232 |
op_container_end_page |
238 |
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1766346512804085760 |