Target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill?
Abstract Background The most common pesticide products for controlling malaria-transmitting mosquitoes combine two distinct modes of action: 1) conventional insecticidal activity which kills mosquitoes exposed to the pesticide and 2) deterrence of mosquitoes away from protected humans. While deterre...
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ftdoajarticles:oai:doaj.org/article:005fce51ff1d40a8ada0733feeb1856b 2023-05-15T15:16:13+02:00 Target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill? Moore Sarah J Chitnis Nakul Killeen Gerry F Okumu Fredros O 2011-07-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-207 https://doaj.org/article/005fce51ff1d40a8ada0733feeb1856b EN eng BMC http://www.malariajournal.com/content/10/1/207 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-207 1475-2875 https://doaj.org/article/005fce51ff1d40a8ada0733feeb1856b Malaria Journal, Vol 10, Iss 1, p 207 (2011) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-207 2022-12-30T21:44:18Z Abstract Background The most common pesticide products for controlling malaria-transmitting mosquitoes combine two distinct modes of action: 1) conventional insecticidal activity which kills mosquitoes exposed to the pesticide and 2) deterrence of mosquitoes away from protected humans. While deterrence enhances personal or household protection of long-lasting insecticidal nets and indoor residual sprays, it may also attenuate or even reverse communal protection if it diverts mosquitoes to non-users rather than killing them outright. Methods A process-explicit model of malaria transmission is described which captures the sequential interaction between deterrent and toxic actions of vector control pesticides and accounts for the distinctive impacts of toxic activities which kill mosquitoes before or after they have fed upon the occupant of a covered house or sleeping space. Results Increasing deterrency increases personal protection but consistently reduces communal protection because deterrent sub-lethal exposure inevitably reduces the proportion subsequently exposed to higher lethal doses. If the high coverage targets of the World Health Organization are achieved, purely toxic products with no deterrence are predicted to generally provide superior protection to non-users and even users, especially where vectors feed exclusively on humans and a substantial amount of transmission occurs outdoors. Remarkably, this is even the case if that product confers no personal protection and only kills mosquitoes after they have fed. Conclusions Products with purely mosquito-toxic profiles may, therefore, be preferable for programmes with universal coverage targets, rather than those with equivalent toxicity but which also have higher deterrence. However, if purely mosquito-toxic products confer little personal protection because they do not deter mosquitoes and only kill them after they have fed, then they will require aggressive "catch up" campaigns, with behaviour change communication strategies that emphasize the communal ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 10 1 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Moore Sarah J Chitnis Nakul Killeen Gerry F Okumu Fredros O Target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill? |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The most common pesticide products for controlling malaria-transmitting mosquitoes combine two distinct modes of action: 1) conventional insecticidal activity which kills mosquitoes exposed to the pesticide and 2) deterrence of mosquitoes away from protected humans. While deterrence enhances personal or household protection of long-lasting insecticidal nets and indoor residual sprays, it may also attenuate or even reverse communal protection if it diverts mosquitoes to non-users rather than killing them outright. Methods A process-explicit model of malaria transmission is described which captures the sequential interaction between deterrent and toxic actions of vector control pesticides and accounts for the distinctive impacts of toxic activities which kill mosquitoes before or after they have fed upon the occupant of a covered house or sleeping space. Results Increasing deterrency increases personal protection but consistently reduces communal protection because deterrent sub-lethal exposure inevitably reduces the proportion subsequently exposed to higher lethal doses. If the high coverage targets of the World Health Organization are achieved, purely toxic products with no deterrence are predicted to generally provide superior protection to non-users and even users, especially where vectors feed exclusively on humans and a substantial amount of transmission occurs outdoors. Remarkably, this is even the case if that product confers no personal protection and only kills mosquitoes after they have fed. Conclusions Products with purely mosquito-toxic profiles may, therefore, be preferable for programmes with universal coverage targets, rather than those with equivalent toxicity but which also have higher deterrence. However, if purely mosquito-toxic products confer little personal protection because they do not deter mosquitoes and only kill them after they have fed, then they will require aggressive "catch up" campaigns, with behaviour change communication strategies that emphasize the communal ... |
format |
Article in Journal/Newspaper |
author |
Moore Sarah J Chitnis Nakul Killeen Gerry F Okumu Fredros O |
author_facet |
Moore Sarah J Chitnis Nakul Killeen Gerry F Okumu Fredros O |
author_sort |
Moore Sarah J |
title |
Target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill? |
title_short |
Target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill? |
title_full |
Target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill? |
title_fullStr |
Target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill? |
title_full_unstemmed |
Target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill? |
title_sort |
target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill? |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-207 https://doaj.org/article/005fce51ff1d40a8ada0733feeb1856b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 10, Iss 1, p 207 (2011) |
op_relation |
http://www.malariajournal.com/content/10/1/207 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-207 1475-2875 https://doaj.org/article/005fce51ff1d40a8ada0733feeb1856b |
op_doi |
https://doi.org/10.1186/1475-2875-10-207 |
container_title |
Malaria Journal |
container_volume |
10 |
container_issue |
1 |
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1766346505464053760 |