Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016
Background The atherosclerotic effect of an adverse lipid profile is assumed to accumulate throughout life, leading to increased risk of myocardial infarction (MI). Still, little is known about age at onset and duration of unfavorable lipid levels before MI. Methods and Results Longitudinal data on...
Published in: | Journal of the American Heart Association |
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ftdoajarticles:oai:doaj.org/article:005402130a294871af7d260ec60d3e35 2023-09-05T13:23:47+02:00 Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 Grethe Albrektsen Tom Wilsgaard Ivar Heuch Maja‐Lisa Løchen Dag Steinar Thelle Inger Njølstad Sameline Grimsgaard Kaare Harald Bønaa 2023-07-01T00:00:00Z https://doi.org/10.1161/JAHA.122.030010 https://doaj.org/article/005402130a294871af7d260ec60d3e35 EN eng Wiley https://www.ahajournals.org/doi/10.1161/JAHA.122.030010 https://doaj.org/toc/2047-9980 doi:10.1161/JAHA.122.030010 2047-9980 https://doaj.org/article/005402130a294871af7d260ec60d3e35 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 14 (2023) incident myocardial infarction lipid profile longitudinal study Diseases of the circulatory (Cardiovascular) system RC666-701 article 2023 ftdoajarticles https://doi.org/10.1161/JAHA.122.030010 2023-08-20T00:35:11Z Background The atherosclerotic effect of an adverse lipid profile is assumed to accumulate throughout life, leading to increased risk of myocardial infarction (MI). Still, little is known about age at onset and duration of unfavorable lipid levels before MI. Methods and Results Longitudinal data on serum lipid levels for 26 130 individuals (50.5% women, aged 20–89 years) were obtained from 7 population‐based health surveys in Tromsø, Norway. Diagnoses of MI were obtained from national registers. A linear mixed model was applied to compare age‐ and sex‐specific mean values of total cholesterol, high‐density lipoprotein cholesterol (HDL‐C), and triglyceride concentration by MI status (MI versus non‐MI). Already from young adulthood, 20 to 35 years before the incident MI, individuals with a subsequent incident MI had on average more adverse lipid levels than individuals of the same age and sex without MI. Analogous to a dose–response relationship, there was a clear trend toward more severe adverse lipid levels the lower the age at incident MI (P<0.001, test for trend through ordered categories <55, 55–74, ≥75 years). This trend was particularly pronounced for high‐density lipoprotein cholesterol in percentage of total cholesterol (both sexes) and for the relative relationship between triglyceride, high‐density lipoprotein cholesterol, and total cholesterol level (women). The difference in mean lipid level by MI status was just as large in women as in men, but the age pattern differed (P≤0.05, tests of 3‐way interaction). Conclusions Compared with general population mean levels, adverse lipid levels were seen 20 to 35 years before the incident MI in both men and women. Article in Journal/Newspaper Tromsø Directory of Open Access Journals: DOAJ Articles Norway Tromsø Journal of the American Heart Association 12 14 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
incident myocardial infarction lipid profile longitudinal study Diseases of the circulatory (Cardiovascular) system RC666-701 |
spellingShingle |
incident myocardial infarction lipid profile longitudinal study Diseases of the circulatory (Cardiovascular) system RC666-701 Grethe Albrektsen Tom Wilsgaard Ivar Heuch Maja‐Lisa Løchen Dag Steinar Thelle Inger Njølstad Sameline Grimsgaard Kaare Harald Bønaa Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 |
topic_facet |
incident myocardial infarction lipid profile longitudinal study Diseases of the circulatory (Cardiovascular) system RC666-701 |
description |
Background The atherosclerotic effect of an adverse lipid profile is assumed to accumulate throughout life, leading to increased risk of myocardial infarction (MI). Still, little is known about age at onset and duration of unfavorable lipid levels before MI. Methods and Results Longitudinal data on serum lipid levels for 26 130 individuals (50.5% women, aged 20–89 years) were obtained from 7 population‐based health surveys in Tromsø, Norway. Diagnoses of MI were obtained from national registers. A linear mixed model was applied to compare age‐ and sex‐specific mean values of total cholesterol, high‐density lipoprotein cholesterol (HDL‐C), and triglyceride concentration by MI status (MI versus non‐MI). Already from young adulthood, 20 to 35 years before the incident MI, individuals with a subsequent incident MI had on average more adverse lipid levels than individuals of the same age and sex without MI. Analogous to a dose–response relationship, there was a clear trend toward more severe adverse lipid levels the lower the age at incident MI (P<0.001, test for trend through ordered categories <55, 55–74, ≥75 years). This trend was particularly pronounced for high‐density lipoprotein cholesterol in percentage of total cholesterol (both sexes) and for the relative relationship between triglyceride, high‐density lipoprotein cholesterol, and total cholesterol level (women). The difference in mean lipid level by MI status was just as large in women as in men, but the age pattern differed (P≤0.05, tests of 3‐way interaction). Conclusions Compared with general population mean levels, adverse lipid levels were seen 20 to 35 years before the incident MI in both men and women. |
format |
Article in Journal/Newspaper |
author |
Grethe Albrektsen Tom Wilsgaard Ivar Heuch Maja‐Lisa Løchen Dag Steinar Thelle Inger Njølstad Sameline Grimsgaard Kaare Harald Bønaa |
author_facet |
Grethe Albrektsen Tom Wilsgaard Ivar Heuch Maja‐Lisa Løchen Dag Steinar Thelle Inger Njølstad Sameline Grimsgaard Kaare Harald Bønaa |
author_sort |
Grethe Albrektsen |
title |
Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 |
title_short |
Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 |
title_full |
Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 |
title_fullStr |
Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 |
title_full_unstemmed |
Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 |
title_sort |
lipid levels during adult lifetime in men and women with and without a subsequent incident myocardial infarction: a longitudinal analysis of data from the tromsø study 1974 to 2016 |
publisher |
Wiley |
publishDate |
2023 |
url |
https://doi.org/10.1161/JAHA.122.030010 https://doaj.org/article/005402130a294871af7d260ec60d3e35 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 14 (2023) |
op_relation |
https://www.ahajournals.org/doi/10.1161/JAHA.122.030010 https://doaj.org/toc/2047-9980 doi:10.1161/JAHA.122.030010 2047-9980 https://doaj.org/article/005402130a294871af7d260ec60d3e35 |
op_doi |
https://doi.org/10.1161/JAHA.122.030010 |
container_title |
Journal of the American Heart Association |
container_volume |
12 |
container_issue |
14 |
_version_ |
1776204358829998080 |