Quality of anti-malarials collected in the private and informal sectors in Guyana and Suriname
Abstract Background Despite a significant reduction in the number of malaria cases in Guyana and Suriname, this disease remains a major problem in the interior of both countries, especially in areas with gold mining and logging operations, where malaria is endemic. National malaria control programme...
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ftdoajarticles:oai:doaj.org/article:002e1b37aa70477c86266b1018b56fc0 2023-05-15T15:16:17+02:00 Quality of anti-malarials collected in the private and informal sectors in Guyana and Suriname Evans Lawrence Coignez Veerle Barojas Adrian Bempong Daniel Bradby Sanford Dijiba Yanga James Makeida Bretas Gustavo Adhin Malti Ceron Nicolas Hinds-Semple Alison Chibwe Kennedy Lukulay Patrick Pribluda Victor 2012-06-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-203 https://doaj.org/article/002e1b37aa70477c86266b1018b56fc0 EN eng BMC http://www.malariajournal.com/content/11/1/203 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-203 1475-2875 https://doaj.org/article/002e1b37aa70477c86266b1018b56fc0 Malaria Journal, Vol 11, Iss 1, p 203 (2012) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-203 2022-12-31T13:51:43Z Abstract Background Despite a significant reduction in the number of malaria cases in Guyana and Suriname, this disease remains a major problem in the interior of both countries, especially in areas with gold mining and logging operations, where malaria is endemic. National malaria control programmes in these countries provide treatment to patients with medicines that are procured and distributed through regulated processes in the public sector. However, availability to medicines in licensed facilities (private sector) and unlicensed facilities (informal sector) is common, posing the risk of access to and use of non-recommended treatments and/or poor quality products. Methods To assess the quality of circulating anti-malarial medicines, samples were purchased in the private and informal sectors of Guyana and Suriname in 2009. The sampling sites were selected based on epidemiological data and/or distance from health facilities. Samples were analysed for identity, content, dissolution or disintegration, impurities, and uniformity of dosage units or weight variation according to manufacturer, pharmacopeial, or other validated method. Results Quality issues were observed in 45 of 77 (58%) anti-malarial medicines sampled in Guyana of which 30 failed visual & physical inspection and 18 failed quality control tests. The proportion of monotherapy and ACT medicines failing quality control tests was 43% (13/30) and 11% (5/47) respectively. A higher proportion of medicines sampled from the private sector 34% (11/32) failed quality control tests versus 16% (7/45) in the informal sector. In Suriname, 58 medicines were sampled, of which 50 (86%) were Artecom®, the fixed-dose combination of piperaquine-dihydroartemisinin-trimethoprim co-blistered with a primaquine phosphate tablet. All Artecom samples were found to lack a label claim for primaquine, thus failing visual and physical inspection. Conclusions The findings of the studies in both countries point to significant problems with the quality of anti-malarial medicines ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Evans Lawrence Coignez Veerle Barojas Adrian Bempong Daniel Bradby Sanford Dijiba Yanga James Makeida Bretas Gustavo Adhin Malti Ceron Nicolas Hinds-Semple Alison Chibwe Kennedy Lukulay Patrick Pribluda Victor Quality of anti-malarials collected in the private and informal sectors in Guyana and Suriname |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Despite a significant reduction in the number of malaria cases in Guyana and Suriname, this disease remains a major problem in the interior of both countries, especially in areas with gold mining and logging operations, where malaria is endemic. National malaria control programmes in these countries provide treatment to patients with medicines that are procured and distributed through regulated processes in the public sector. However, availability to medicines in licensed facilities (private sector) and unlicensed facilities (informal sector) is common, posing the risk of access to and use of non-recommended treatments and/or poor quality products. Methods To assess the quality of circulating anti-malarial medicines, samples were purchased in the private and informal sectors of Guyana and Suriname in 2009. The sampling sites were selected based on epidemiological data and/or distance from health facilities. Samples were analysed for identity, content, dissolution or disintegration, impurities, and uniformity of dosage units or weight variation according to manufacturer, pharmacopeial, or other validated method. Results Quality issues were observed in 45 of 77 (58%) anti-malarial medicines sampled in Guyana of which 30 failed visual & physical inspection and 18 failed quality control tests. The proportion of monotherapy and ACT medicines failing quality control tests was 43% (13/30) and 11% (5/47) respectively. A higher proportion of medicines sampled from the private sector 34% (11/32) failed quality control tests versus 16% (7/45) in the informal sector. In Suriname, 58 medicines were sampled, of which 50 (86%) were Artecom®, the fixed-dose combination of piperaquine-dihydroartemisinin-trimethoprim co-blistered with a primaquine phosphate tablet. All Artecom samples were found to lack a label claim for primaquine, thus failing visual and physical inspection. Conclusions The findings of the studies in both countries point to significant problems with the quality of anti-malarial medicines ... |
format |
Article in Journal/Newspaper |
author |
Evans Lawrence Coignez Veerle Barojas Adrian Bempong Daniel Bradby Sanford Dijiba Yanga James Makeida Bretas Gustavo Adhin Malti Ceron Nicolas Hinds-Semple Alison Chibwe Kennedy Lukulay Patrick Pribluda Victor |
author_facet |
Evans Lawrence Coignez Veerle Barojas Adrian Bempong Daniel Bradby Sanford Dijiba Yanga James Makeida Bretas Gustavo Adhin Malti Ceron Nicolas Hinds-Semple Alison Chibwe Kennedy Lukulay Patrick Pribluda Victor |
author_sort |
Evans Lawrence |
title |
Quality of anti-malarials collected in the private and informal sectors in Guyana and Suriname |
title_short |
Quality of anti-malarials collected in the private and informal sectors in Guyana and Suriname |
title_full |
Quality of anti-malarials collected in the private and informal sectors in Guyana and Suriname |
title_fullStr |
Quality of anti-malarials collected in the private and informal sectors in Guyana and Suriname |
title_full_unstemmed |
Quality of anti-malarials collected in the private and informal sectors in Guyana and Suriname |
title_sort |
quality of anti-malarials collected in the private and informal sectors in guyana and suriname |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-203 https://doaj.org/article/002e1b37aa70477c86266b1018b56fc0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 203 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/203 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-203 1475-2875 https://doaj.org/article/002e1b37aa70477c86266b1018b56fc0 |
op_doi |
https://doi.org/10.1186/1475-2875-11-203 |
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Malaria Journal |
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11 |
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1 |
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1766346565400657920 |