Risk factors for persistent gestational trophoblastic neoplasia

• Main Authors: Kuyumcuoglu U., Guzel A.I., Erdemoglu M., Celik Y.
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2011
• Subjects: Gestational Trophoblastic Neoplasms; Persistent; Risk Factors; GTN-P
• Online Access: https://hdl.handle.net/11468/24974

This retrospective study evaluated the risk factors for persistent gestational trophoblastic disease (GTN) and determined their odds ratios. This study included 100 cases with GTN admitted to our clinic. Possible risk factors recorded were age, gravidity, parity, size of the neoplasia, and ?-human chorionic gonadotropin levels (?-hCG) before and after the procedure. Statistical analyses consisted of the independent sample t-test and logistic regression using the statistical package SPSS ver. 15.0 for Windows (SPSS, Chicago, IL, USA). Twenty of the cases had persistent GTN, and the differences between these and the others cases were evaluated. The size of the neoplasia and histopathological type of GTN had no statistical relationship with persistence, whereas age, gravidity, and ?-hCG levels were significant risk factors for persistent GTN (p < 0.05). The odds ratios (95% confidence interval (CI)) for age, gravidity, and pre- and post-evacuation ?-hCG levels determined using logistic regression were 4.678 (0.97-22.44), 7.315 (1.16-46.16), 2.637 (1.41-4.94), and 2.339 (1.52-3.60), respectively. Patient age, gravidity, and ?-hCG levels were risk factors for persistent GTN, whereas the size of the neoplasia and histopathological type of GTN were not significant risk factors. © 2010 Old City Publishing, Inc.