Efecto en los niveles de colesterol total de la Sitagliptina en ratas con diabetes
Diabetes Mellitus (DM) is a syndrome of metabolic disorders with hyperglycemia, which produces an absolute or relative insulin deficiency. The effects of treatment of type II DM with Sitagliptin on lipid metabolism in general or particularly on homeostasis of body cholesterol have been scarcely stud...
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ftdialnet:oai:dialnet.unirioja.es:ART0001459528 2023-05-15T18:05:40+02:00 Efecto en los niveles de colesterol total de la Sitagliptina en ratas con diabetes Rodríguez Vega, Juan Luis Sánchez Moreno, Héctor Melvin García Ishimine, Richard Arellano Sánchez, César Wilson 2020 application/pdf https://dialnet.unirioja.es/servlet/oaiart?codigo=7946097 spa spa https://dialnet.unirioja.es/servlet/oaiart?codigo=7946097 (Revista) ISSN 2414-8695 (Revista) ISSN 2305-8552 LICENCIA DE USO: Los documentos a texto completo incluidos en Dialnet son de acceso libre y propiedad de sus autores y/o editores. Por tanto, cualquier acto de reproducción, distribución, comunicación pública y/o transformación total o parcial requiere el consentimiento expreso y escrito de aquéllos. Cualquier enlace al texto completo de estos documentos deberá hacerse a través de la URL oficial de éstos en Dialnet. Más información: https://dialnet.unirioja.es/info/derechosOAI | INTELLECTUAL PROPERTY RIGHTS STATEMENT: Full text documents hosted by Dialnet are protected by copyright and/or related rights. This digital object is accessible without charge, but its use is subject to the licensing conditions set by its authors or editors. Unless expressly stated otherwise in the licensing conditions, you are free to linking, browsing, printing and making a copy for your own personal purposes. All other acts of reproduction and communication to the public are subject to the licensing conditions expressed by editors and authors and require consent from them. Any link to this document should be made using its official URL in Dialnet. More info: https://dialnet.unirioja.es/info/derechosOAI UCV - HACER: Revista de Investigación y Cultura, ISSN 2305-8552, Vol. 9, Nº. 3 (Julio-Septiembre), 2020, pags. 11-17 text (article) 2020 ftdialnet 2021-11-03T08:40:27Z Diabetes Mellitus (DM) is a syndrome of metabolic disorders with hyperglycemia, which produces an absolute or relative insulin deficiency. The effects of treatment of type II DM with Sitagliptin on lipid metabolism in general or particularly on homeostasis of body cholesterol have been scarcely studied. For this reason, the control of dyslipidemias in patients with type II DM is transcendental, the objective being: to determine the effect on total cholesterol levels of sitapgliptin, in Rattus rattus var. Albinus with streptozotocin induced diabetes. We followed an experimental, prospective longitudinal-sectional study, was selected 20 male albino rats; chosen at random, grouped into n = 10: Gl (Control group), with diabetes induced intraperitoneally in a dose of streptozotocin (40 mg / Kg) and G-II (experimental group), with diabetes induced with Streptozotocin (40mg / kg) and treated with 0.6% Sitagliptin. For measurements were used the Accutrend® Plus kit, which measures the intensity of the color produced in the reactive layer of the test strip, through reflectance photometry. In Group I, a slight increase in serum cholesterol concentration was observed and in Group II, there was a considerable increase in serum cholesterol concentration; according to 1, 5, 15 and 20 days of exposure at 95% confidence, with p <0.05 having statistical significance. Comparing the changes in serum concentration of total cholesterol, an increase in these levels was shown , as an adverse drug reaction of Sitagliptin.Keywords: Serum cholesterol concentration, hyperglycemia, Sitagliptin La Diabetes Mellitus (DM) es un síndrome de alteraciones metabólicas con hiperglucemia, que produce una deficiencia absoluta o relativa de insulina. Los efectos del tratamiento de la DM tipo II con Sitagliptina sobre el metabolismo lipídico en general o particularmente sobre la homeostasis del colesterol corporal han sido escasamente estudiados. Por esta razón resulta trascendental el control de las dislipidemias en los pacientes con DM tipo II, ... Article in Journal/Newspaper Rattus rattus Dialnet - Portada de revistas (Universidad de La Rioja) |
institution |
Open Polar |
collection |
Dialnet - Portada de revistas (Universidad de La Rioja) |
op_collection_id |
ftdialnet |
language |
Spanish |
description |
Diabetes Mellitus (DM) is a syndrome of metabolic disorders with hyperglycemia, which produces an absolute or relative insulin deficiency. The effects of treatment of type II DM with Sitagliptin on lipid metabolism in general or particularly on homeostasis of body cholesterol have been scarcely studied. For this reason, the control of dyslipidemias in patients with type II DM is transcendental, the objective being: to determine the effect on total cholesterol levels of sitapgliptin, in Rattus rattus var. Albinus with streptozotocin induced diabetes. We followed an experimental, prospective longitudinal-sectional study, was selected 20 male albino rats; chosen at random, grouped into n = 10: Gl (Control group), with diabetes induced intraperitoneally in a dose of streptozotocin (40 mg / Kg) and G-II (experimental group), with diabetes induced with Streptozotocin (40mg / kg) and treated with 0.6% Sitagliptin. For measurements were used the Accutrend® Plus kit, which measures the intensity of the color produced in the reactive layer of the test strip, through reflectance photometry. In Group I, a slight increase in serum cholesterol concentration was observed and in Group II, there was a considerable increase in serum cholesterol concentration; according to 1, 5, 15 and 20 days of exposure at 95% confidence, with p <0.05 having statistical significance. Comparing the changes in serum concentration of total cholesterol, an increase in these levels was shown , as an adverse drug reaction of Sitagliptin.Keywords: Serum cholesterol concentration, hyperglycemia, Sitagliptin La Diabetes Mellitus (DM) es un síndrome de alteraciones metabólicas con hiperglucemia, que produce una deficiencia absoluta o relativa de insulina. Los efectos del tratamiento de la DM tipo II con Sitagliptina sobre el metabolismo lipídico en general o particularmente sobre la homeostasis del colesterol corporal han sido escasamente estudiados. Por esta razón resulta trascendental el control de las dislipidemias en los pacientes con DM tipo II, ... |
format |
Article in Journal/Newspaper |
author |
Rodríguez Vega, Juan Luis Sánchez Moreno, Héctor Melvin García Ishimine, Richard Arellano Sánchez, César Wilson |
spellingShingle |
Rodríguez Vega, Juan Luis Sánchez Moreno, Héctor Melvin García Ishimine, Richard Arellano Sánchez, César Wilson Efecto en los niveles de colesterol total de la Sitagliptina en ratas con diabetes |
author_facet |
Rodríguez Vega, Juan Luis Sánchez Moreno, Héctor Melvin García Ishimine, Richard Arellano Sánchez, César Wilson |
author_sort |
Rodríguez Vega, Juan Luis |
title |
Efecto en los niveles de colesterol total de la Sitagliptina en ratas con diabetes |
title_short |
Efecto en los niveles de colesterol total de la Sitagliptina en ratas con diabetes |
title_full |
Efecto en los niveles de colesterol total de la Sitagliptina en ratas con diabetes |
title_fullStr |
Efecto en los niveles de colesterol total de la Sitagliptina en ratas con diabetes |
title_full_unstemmed |
Efecto en los niveles de colesterol total de la Sitagliptina en ratas con diabetes |
title_sort |
efecto en los niveles de colesterol total de la sitagliptina en ratas con diabetes |
publishDate |
2020 |
url |
https://dialnet.unirioja.es/servlet/oaiart?codigo=7946097 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
UCV - HACER: Revista de Investigación y Cultura, ISSN 2305-8552, Vol. 9, Nº. 3 (Julio-Septiembre), 2020, pags. 11-17 |
op_relation |
https://dialnet.unirioja.es/servlet/oaiart?codigo=7946097 (Revista) ISSN 2414-8695 (Revista) ISSN 2305-8552 |
op_rights |
LICENCIA DE USO: Los documentos a texto completo incluidos en Dialnet son de acceso libre y propiedad de sus autores y/o editores. Por tanto, cualquier acto de reproducción, distribución, comunicación pública y/o transformación total o parcial requiere el consentimiento expreso y escrito de aquéllos. Cualquier enlace al texto completo de estos documentos deberá hacerse a través de la URL oficial de éstos en Dialnet. Más información: https://dialnet.unirioja.es/info/derechosOAI | INTELLECTUAL PROPERTY RIGHTS STATEMENT: Full text documents hosted by Dialnet are protected by copyright and/or related rights. This digital object is accessible without charge, but its use is subject to the licensing conditions set by its authors or editors. Unless expressly stated otherwise in the licensing conditions, you are free to linking, browsing, printing and making a copy for your own personal purposes. All other acts of reproduction and communication to the public are subject to the licensing conditions expressed by editors and authors and require consent from them. Any link to this document should be made using its official URL in Dialnet. More info: https://dialnet.unirioja.es/info/derechosOAI |
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