An investigation on the cytogenotoxic effects of a spurge species (Euphorbia grisophylla) with partial ethnomedical use in Turkey
The effects of the aqueous extract obtained from the aerial parts of Euphorbia grisophylla M.L.S.Khan, a herbaceous member of the Euphorbiaceae family, which is common in other parts of the world outside the Antarctic continent, on genotoxic, cytotoxic, and oxidative parameters were investigated. Ex...
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Çukurova Üniversitesi
2022
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ftdergipark2ojs:oai:dergipark.org.tr:article/1215929 2023-05-15T14:10:48+02:00 An investigation on the cytogenotoxic effects of a spurge species (Euphorbia grisophylla) with partial ethnomedical use in Turkey POLAT, Sedat İLA, Hasan Basri 2022-12-07 application/pdf https://dergipark.org.tr/tr/pub/cunas/issue/75039/1215929 eng eng Çukurova Üniversitesi Cukurova University https://dergipark.org.tr/tr/download/article-file/2818391 https://dergipark.org.tr/tr/pub/cunas/issue/75039/1215929 Volume: 2, Issue: 1 11-26 2822-2938 Cukurova University Journal of Natural and Applied Sciences - Euphorbia grisophylla;Cytogenotoxicity;Micronucleus (MN) test;Ames/Salmonella test;Comet assay Temel Bilimler Basic Sciences info:eu-repo/semantics/article 2022 ftdergipark2ojs 2023-03-23T18:06:18Z The effects of the aqueous extract obtained from the aerial parts of Euphorbia grisophylla M.L.S.Khan, a herbaceous member of the Euphorbiaceae family, which is common in other parts of the world outside the Antarctic continent, on genotoxic, cytotoxic, and oxidative parameters were investigated. Experiments were carried out under short-term and in vitro conditions with sublethal concentrations of the test substance extract. According to the first results, the plant extract did not significantly affect the oxidative stress indicators in cell culture. Similarly, it increased the micronucleus ratio in lymphocytes insignificantly, but the concentration-effect relationship is significant in the 24-hour treatment. Again, the test substance did not induce an evident reversion-type mutation in the Ames test. However, the percentage of damaged cells in the Comet test and the genetic damage index increased significantly except for the lowest concentration. The cytotoxic effect observed in the context of the same pattern with these findings is remarkable. In conclusion, the slightly clastogenic and cytotoxic effect of Euphorbia grisophylla aqueous extract, not based on the oxidative attack, may provide a new projection for further research, like cancer therapy. Article in Journal/Newspaper Antarc* Antarctic DergiPark Akademik (E-Journals) Antarctic The Antarctic |
institution |
Open Polar |
collection |
DergiPark Akademik (E-Journals) |
op_collection_id |
ftdergipark2ojs |
language |
English |
topic |
Euphorbia grisophylla;Cytogenotoxicity;Micronucleus (MN) test;Ames/Salmonella test;Comet assay Temel Bilimler Basic Sciences |
spellingShingle |
Euphorbia grisophylla;Cytogenotoxicity;Micronucleus (MN) test;Ames/Salmonella test;Comet assay Temel Bilimler Basic Sciences POLAT, Sedat İLA, Hasan Basri An investigation on the cytogenotoxic effects of a spurge species (Euphorbia grisophylla) with partial ethnomedical use in Turkey |
topic_facet |
Euphorbia grisophylla;Cytogenotoxicity;Micronucleus (MN) test;Ames/Salmonella test;Comet assay Temel Bilimler Basic Sciences |
description |
The effects of the aqueous extract obtained from the aerial parts of Euphorbia grisophylla M.L.S.Khan, a herbaceous member of the Euphorbiaceae family, which is common in other parts of the world outside the Antarctic continent, on genotoxic, cytotoxic, and oxidative parameters were investigated. Experiments were carried out under short-term and in vitro conditions with sublethal concentrations of the test substance extract. According to the first results, the plant extract did not significantly affect the oxidative stress indicators in cell culture. Similarly, it increased the micronucleus ratio in lymphocytes insignificantly, but the concentration-effect relationship is significant in the 24-hour treatment. Again, the test substance did not induce an evident reversion-type mutation in the Ames test. However, the percentage of damaged cells in the Comet test and the genetic damage index increased significantly except for the lowest concentration. The cytotoxic effect observed in the context of the same pattern with these findings is remarkable. In conclusion, the slightly clastogenic and cytotoxic effect of Euphorbia grisophylla aqueous extract, not based on the oxidative attack, may provide a new projection for further research, like cancer therapy. |
format |
Article in Journal/Newspaper |
author |
POLAT, Sedat İLA, Hasan Basri |
author_facet |
POLAT, Sedat İLA, Hasan Basri |
author_sort |
POLAT, Sedat |
title |
An investigation on the cytogenotoxic effects of a spurge species (Euphorbia grisophylla) with partial ethnomedical use in Turkey |
title_short |
An investigation on the cytogenotoxic effects of a spurge species (Euphorbia grisophylla) with partial ethnomedical use in Turkey |
title_full |
An investigation on the cytogenotoxic effects of a spurge species (Euphorbia grisophylla) with partial ethnomedical use in Turkey |
title_fullStr |
An investigation on the cytogenotoxic effects of a spurge species (Euphorbia grisophylla) with partial ethnomedical use in Turkey |
title_full_unstemmed |
An investigation on the cytogenotoxic effects of a spurge species (Euphorbia grisophylla) with partial ethnomedical use in Turkey |
title_sort |
investigation on the cytogenotoxic effects of a spurge species (euphorbia grisophylla) with partial ethnomedical use in turkey |
publisher |
Çukurova Üniversitesi |
publishDate |
2022 |
url |
https://dergipark.org.tr/tr/pub/cunas/issue/75039/1215929 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Volume: 2, Issue: 1 11-26 2822-2938 Cukurova University Journal of Natural and Applied Sciences - |
op_relation |
https://dergipark.org.tr/tr/download/article-file/2818391 https://dergipark.org.tr/tr/pub/cunas/issue/75039/1215929 |
_version_ |
1766282893874692096 |