QTLs Associated with Resistance to Cardiomyopathy Syndrome in Atlantic Salmon
AbstractCardiomyopathy syndrome (CMS) caused by piscine myocarditis virus is a major disease affecting the Norwegian Atlantic salmon industry. Three different populations of Atlantic salmon from the Mowi breeding program were used in this study. The first 2 populations (population 1 and 2) were natu...
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ftdeakinunifig:oai:figshare.com:article/24419818 2024-09-09T19:30:17+00:00 QTLs Associated with Resistance to Cardiomyopathy Syndrome in Atlantic Salmon S Boison J Ding E Leder B Gjerde PH Bergtun A Norris M Baranski Nick Robinson 2019-09-01T00:00:00Z http://hdl.handle.net/10779/DRO/DU:24419818.v3 https://figshare.com/articles/journal_contribution/QTLs_Associated_with_Resistance_to_Cardiomyopathy_Syndrome_in_Atlantic_Salmon/24419818 unknown http://hdl.handle.net/10779/DRO/DU:24419818.v3 https://figshare.com/articles/journal_contribution/QTLs_Associated_with_Resistance_to_Cardiomyopathy_Syndrome_in_Atlantic_Salmon/24419818 CC BY-NC 4.0 Biological sciences Evolutionary biology Genetics Atlantic salmon cardiomyopathy syndrome CLASS-I COXSACKIEVIRUS DISEASE RESISTANCE field outbreak genetic correlations GENETIC EVALUATION Genetics & Heredity heritability INFECTIOUS PANCREATIC NECROSIS Life Sciences & Biomedicine POPULATION PREDICTION QTL analysis SALAR L Science & Technology SELECTION STATE Text Journal contribution 2019 ftdeakinunifig 2024-06-20T00:31:11Z AbstractCardiomyopathy syndrome (CMS) caused by piscine myocarditis virus is a major disease affecting the Norwegian Atlantic salmon industry. Three different populations of Atlantic salmon from the Mowi breeding program were used in this study. The first 2 populations (population 1 and 2) were naturally infected in a field outbreak, while the third population (population 3) went through a controlled challenged test. The aim of the study was to estimate the heritability, the genetic correlation between populations and perform genome-wide association analysis for resistance to this disease. Survival data from population 1 and 2 and heart atrium histology score data from population 3 was analyzed. A total of 571, 4312, and 901 fish from population 1, 2, and 3, respectively were genotyped with a noncommercial 55,735 Affymetrix marker panel. Genomic heritability ranged from 0.12 to 0.46 and the highest estimate was obtained from the challenge test dataset. The genetic correlation between populations was moderate (0.51–0.61). Two chromosomal regions (SSA27 and SSA12) contained single nucleotide polymorphisms associated with resistance to CMS. The highest association signal (P = 6.9751 × 10−27) was found on chromosome 27. Four genes with functional roles affecting viral resistance (magi1, pi4kb, bnip2, and ha1f) were found to map closely to the identified quantitative trait loci (QTLs). In conclusion, genetic variation for resistance to CMS was observed in all 3 populations. Two important quantitative trait loci were detected which together explain half of the total genetic variance, suggesting strong potential application for marker-assisted selection and genomic predictions to improve CMS resistance. Article in Journal/Newspaper Atlantic salmon DRO - Deakin Research Online |
institution |
Open Polar |
collection |
DRO - Deakin Research Online |
op_collection_id |
ftdeakinunifig |
language |
unknown |
topic |
Biological sciences Evolutionary biology Genetics Atlantic salmon cardiomyopathy syndrome CLASS-I COXSACKIEVIRUS DISEASE RESISTANCE field outbreak genetic correlations GENETIC EVALUATION Genetics & Heredity heritability INFECTIOUS PANCREATIC NECROSIS Life Sciences & Biomedicine POPULATION PREDICTION QTL analysis SALAR L Science & Technology SELECTION STATE |
spellingShingle |
Biological sciences Evolutionary biology Genetics Atlantic salmon cardiomyopathy syndrome CLASS-I COXSACKIEVIRUS DISEASE RESISTANCE field outbreak genetic correlations GENETIC EVALUATION Genetics & Heredity heritability INFECTIOUS PANCREATIC NECROSIS Life Sciences & Biomedicine POPULATION PREDICTION QTL analysis SALAR L Science & Technology SELECTION STATE S Boison J Ding E Leder B Gjerde PH Bergtun A Norris M Baranski Nick Robinson QTLs Associated with Resistance to Cardiomyopathy Syndrome in Atlantic Salmon |
topic_facet |
Biological sciences Evolutionary biology Genetics Atlantic salmon cardiomyopathy syndrome CLASS-I COXSACKIEVIRUS DISEASE RESISTANCE field outbreak genetic correlations GENETIC EVALUATION Genetics & Heredity heritability INFECTIOUS PANCREATIC NECROSIS Life Sciences & Biomedicine POPULATION PREDICTION QTL analysis SALAR L Science & Technology SELECTION STATE |
description |
AbstractCardiomyopathy syndrome (CMS) caused by piscine myocarditis virus is a major disease affecting the Norwegian Atlantic salmon industry. Three different populations of Atlantic salmon from the Mowi breeding program were used in this study. The first 2 populations (population 1 and 2) were naturally infected in a field outbreak, while the third population (population 3) went through a controlled challenged test. The aim of the study was to estimate the heritability, the genetic correlation between populations and perform genome-wide association analysis for resistance to this disease. Survival data from population 1 and 2 and heart atrium histology score data from population 3 was analyzed. A total of 571, 4312, and 901 fish from population 1, 2, and 3, respectively were genotyped with a noncommercial 55,735 Affymetrix marker panel. Genomic heritability ranged from 0.12 to 0.46 and the highest estimate was obtained from the challenge test dataset. The genetic correlation between populations was moderate (0.51–0.61). Two chromosomal regions (SSA27 and SSA12) contained single nucleotide polymorphisms associated with resistance to CMS. The highest association signal (P = 6.9751 × 10−27) was found on chromosome 27. Four genes with functional roles affecting viral resistance (magi1, pi4kb, bnip2, and ha1f) were found to map closely to the identified quantitative trait loci (QTLs). In conclusion, genetic variation for resistance to CMS was observed in all 3 populations. Two important quantitative trait loci were detected which together explain half of the total genetic variance, suggesting strong potential application for marker-assisted selection and genomic predictions to improve CMS resistance. |
format |
Article in Journal/Newspaper |
author |
S Boison J Ding E Leder B Gjerde PH Bergtun A Norris M Baranski Nick Robinson |
author_facet |
S Boison J Ding E Leder B Gjerde PH Bergtun A Norris M Baranski Nick Robinson |
author_sort |
S Boison |
title |
QTLs Associated with Resistance to Cardiomyopathy Syndrome in Atlantic Salmon |
title_short |
QTLs Associated with Resistance to Cardiomyopathy Syndrome in Atlantic Salmon |
title_full |
QTLs Associated with Resistance to Cardiomyopathy Syndrome in Atlantic Salmon |
title_fullStr |
QTLs Associated with Resistance to Cardiomyopathy Syndrome in Atlantic Salmon |
title_full_unstemmed |
QTLs Associated with Resistance to Cardiomyopathy Syndrome in Atlantic Salmon |
title_sort |
qtls associated with resistance to cardiomyopathy syndrome in atlantic salmon |
publishDate |
2019 |
url |
http://hdl.handle.net/10779/DRO/DU:24419818.v3 https://figshare.com/articles/journal_contribution/QTLs_Associated_with_Resistance_to_Cardiomyopathy_Syndrome_in_Atlantic_Salmon/24419818 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
http://hdl.handle.net/10779/DRO/DU:24419818.v3 https://figshare.com/articles/journal_contribution/QTLs_Associated_with_Resistance_to_Cardiomyopathy_Syndrome_in_Atlantic_Salmon/24419818 |
op_rights |
CC BY-NC 4.0 |
_version_ |
1809899277284016128 |