The fur seal — a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution
Mammary gland involution requires co-ordination of milk production, immune responses, apoptosis and remodeling. Initiation and progression of each of these components involves integral control by the mammary gland. Although cell-based culture models and genetically manipulated animals have shed ligh...
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ftdeakinunifig:oai:figshare.com:article/21000646 2023-05-15T15:23:12+02:00 The fur seal — a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution Julie Sharp Christophe Lefevre A Brennan Kevin Nicholas 2007-03-01T00:00:00Z http://hdl.handle.net/10536/DRO/DU:30040974 https://figshare.com/articles/journal_contribution/The_fur_seal_a_model_lactation_phenotype_to_explore_molecular_factors_involved_in_the_initiation_of_apoptosis_at_involution/21000646 unknown http://hdl.handle.net/10536/DRO/DU:30040974 https://figshare.com/articles/journal_contribution/The_fur_seal_a_model_lactation_phenotype_to_explore_molecular_factors_involved_in_the_initiation_of_apoptosis_at_involution/21000646 All Rights Reserved Uncategorized Fur seal Lactation Local control Mammary gland Involution Acute phase response Science & Technology Life Sciences & Biomedicine Oncology Endocrinology & Metabolism Physiology MAMMARY-GLAND INVOLUTION WALLABY MACROPUS-EUGENII PROGRAMMED CELL-DEATH GROWTH-FACTOR-I EPITHELIAL-CELLS TAMMAR WALLABY ALPHA-LACTALBUMIN GENE-EXPRESSION ARCTOCEPHALUS-GAZELLA ATTENDANCE PATTERNS Text Journal contribution 2007 ftdeakinunifig 2022-11-17T22:17:45Z Mammary gland involution requires co-ordination of milk production, immune responses, apoptosis and remodeling. Initiation and progression of each of these components involves integral control by the mammary gland. Although cell-based culture models and genetically manipulated animals have shed light on these processes, the factors controlling each step in the involution cascade are still poorly understood. The fur seal displays a unique lactation phenotype. During the lactation cycle the mammary gland downregulates milk production and initiates an immune response but fails to initiate the apoptotic phase of involution, allowing the female fur seal to undertake long foraging trips of up to 28 days between suckling bouts. Upon return to shore the female continues feeding her pup following resumption of lactation and milk production. Expression profiling of genes involved in this lactation cycle provides valuable tools for investigation of the factors responsible for the initiation of apoptosis at involution. Other Non-Article Part of Journal/Newspaper Arctocephalus gazella DRO - Deakin Research Online |
institution |
Open Polar |
collection |
DRO - Deakin Research Online |
op_collection_id |
ftdeakinunifig |
language |
unknown |
topic |
Uncategorized Fur seal Lactation Local control Mammary gland Involution Acute phase response Science & Technology Life Sciences & Biomedicine Oncology Endocrinology & Metabolism Physiology MAMMARY-GLAND INVOLUTION WALLABY MACROPUS-EUGENII PROGRAMMED CELL-DEATH GROWTH-FACTOR-I EPITHELIAL-CELLS TAMMAR WALLABY ALPHA-LACTALBUMIN GENE-EXPRESSION ARCTOCEPHALUS-GAZELLA ATTENDANCE PATTERNS |
spellingShingle |
Uncategorized Fur seal Lactation Local control Mammary gland Involution Acute phase response Science & Technology Life Sciences & Biomedicine Oncology Endocrinology & Metabolism Physiology MAMMARY-GLAND INVOLUTION WALLABY MACROPUS-EUGENII PROGRAMMED CELL-DEATH GROWTH-FACTOR-I EPITHELIAL-CELLS TAMMAR WALLABY ALPHA-LACTALBUMIN GENE-EXPRESSION ARCTOCEPHALUS-GAZELLA ATTENDANCE PATTERNS Julie Sharp Christophe Lefevre A Brennan Kevin Nicholas The fur seal — a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution |
topic_facet |
Uncategorized Fur seal Lactation Local control Mammary gland Involution Acute phase response Science & Technology Life Sciences & Biomedicine Oncology Endocrinology & Metabolism Physiology MAMMARY-GLAND INVOLUTION WALLABY MACROPUS-EUGENII PROGRAMMED CELL-DEATH GROWTH-FACTOR-I EPITHELIAL-CELLS TAMMAR WALLABY ALPHA-LACTALBUMIN GENE-EXPRESSION ARCTOCEPHALUS-GAZELLA ATTENDANCE PATTERNS |
description |
Mammary gland involution requires co-ordination of milk production, immune responses, apoptosis and remodeling. Initiation and progression of each of these components involves integral control by the mammary gland. Although cell-based culture models and genetically manipulated animals have shed light on these processes, the factors controlling each step in the involution cascade are still poorly understood. The fur seal displays a unique lactation phenotype. During the lactation cycle the mammary gland downregulates milk production and initiates an immune response but fails to initiate the apoptotic phase of involution, allowing the female fur seal to undertake long foraging trips of up to 28 days between suckling bouts. Upon return to shore the female continues feeding her pup following resumption of lactation and milk production. Expression profiling of genes involved in this lactation cycle provides valuable tools for investigation of the factors responsible for the initiation of apoptosis at involution. |
format |
Other Non-Article Part of Journal/Newspaper |
author |
Julie Sharp Christophe Lefevre A Brennan Kevin Nicholas |
author_facet |
Julie Sharp Christophe Lefevre A Brennan Kevin Nicholas |
author_sort |
Julie Sharp |
title |
The fur seal — a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution |
title_short |
The fur seal — a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution |
title_full |
The fur seal — a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution |
title_fullStr |
The fur seal — a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution |
title_full_unstemmed |
The fur seal — a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution |
title_sort |
fur seal — a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution |
publishDate |
2007 |
url |
http://hdl.handle.net/10536/DRO/DU:30040974 https://figshare.com/articles/journal_contribution/The_fur_seal_a_model_lactation_phenotype_to_explore_molecular_factors_involved_in_the_initiation_of_apoptosis_at_involution/21000646 |
genre |
Arctocephalus gazella |
genre_facet |
Arctocephalus gazella |
op_relation |
http://hdl.handle.net/10536/DRO/DU:30040974 https://figshare.com/articles/journal_contribution/The_fur_seal_a_model_lactation_phenotype_to_explore_molecular_factors_involved_in_the_initiation_of_apoptosis_at_involution/21000646 |
op_rights |
All Rights Reserved |
_version_ |
1766353913781420032 |