Modelling grouped survival times in toxicological studies using generalized additive models

• Main Authors: SG Candy, BJ Sfiligoj, CK King, Julie Mondon
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: 2014
• Subjects: Dose–response model; Generalized Additive Model; Grouped survival times; Time–response model; 050204 Environmental Impact Assessment; 970105 Expanding Knowledge in the Environmental Sciences; Centre for Integrative Ecology; Environmental Sustainability Research Group; School of Life and Environmental Sciences; Antarctic; Gam; Antarc*
• Online Access: http://hdl.handle.net/10536/DRO/DU:30069277; https://figshare.com/articles/journal_contribution/Modelling_grouped_survival_times_in_toxicological_studies_using_generalized_additive_models/20917198

A method for combining a proportional-hazards survival time model with a bioassay model where the log-hazard function is modelled as a linear or smoothing spline function of log-concentration combined with a smoothing spline function of time is described. The combined model is fitted to mortality nu...