Lipase-produced hydroxytyrosyl eicosapentaenoate is an excellent antioxidant for the stabilization of omega-3 bulk oils, emulsions and microcapsules

• Main Authors: TO Akanbi, Colin Barrow
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: 2018
• Subjects: Analytical chemistry not elsewhere classified; Medicinal and biomolecular chemistry not elsewhere classified; Organic chemistry not elsewhere classified; Theoretical and computational chemistry not elsewhere classified; Science & Technology; Life Sciences & Biomedicine; Physical Sciences; Biochemistry & Molecular Biology; Chemistry; Multidisciplinary; hydroxytyrosol; eicosapentaenoic acid; antioxidant; microencapsulation; lipase; Candida antarctica B; enzyme; conjugation; PHENOLIC-COMPOUNDS; STRUCTURED LIPIDS; TUNA OIL; ESTERS; ACID; DERIVATIVES; TYROSOL; WATER; FISH; Centre for Chemistry and Biotechnology; School of Life and Environmental Sciences; 3401 Analytical chemistry; 3404 Medicinal and biomolecular chemistry; 3405 Organic chemistry; Antarc*; Antarctica
• Online Access: http://hdl.handle.net/10536/DRO/DU:30107974; https://figshare.com/articles/journal_contribution/Lipase-produced_hydroxytyrosyl_eicosapentaenoate_is_an_excellent_antioxidant_for_the_stabilization_of_omega-3_bulk_oils_emulsions_and_microcapsules/20814109

In this study, several lipophilic hydroxytyrosyl esters were prepared enzymatically using immobilized lipase from Candida antarctica B. Oxidation tests showed that these conjugates are excellent antioxidants in lipid-based matrices, with hydroxytyrosyl eicosapentaenoate showing the highest antioxidant activity. Hydroxytyrosyl eicosapentaenoate effectively stabilized bulk fish oil, fish-oil-in-water emulsions and microencapsulated fish oil. The stabilizing effect of this antioxidant may either be because it orients itself with the omega-3 fatty acids in the oil, thereby protecting them against oxidation, or because this unstable fatty acid can preferentially oxidise, thus providing an additional mechanism of antioxidant protection. Hydroxytyrosyl eicosapentaenoate itself was stable for one year when stored at -20 °C.