Design considerations for pulsed-flow comprehensive two-dimensional GC: Dynamic flow model approach

• Main Authors: PMA Harvey, Robert Shellie, PR Haddad
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: 2010
• Subjects: Analytical chemistry not elsewhere classified; Other chemical sciences not elsewhere classified; Uncategorised value; Antarctic; Antarc*
• Online Access: http://hdl.handle.net/10536/DRO/DU:30113915; https://figshare.com/articles/journal_contribution/Design_considerations_for_pulsed-flow_comprehensive_two-dimensional_GC_Dynamic_flow_model_approach/20792494

A dynamic flow model, which maps carrier gas pressures and carrier gas flow rates through the first dimension separation column, the modulator sample loop, and the second dimension separation column(s) in a pulsed-flow modulation comprehensive two-dimensional gas chromatography (PFM-GC×GC) system is described. The dynamic flow model assists design of a PFM-GC×GC modulator and leads to rapid determination of pneumatic conditions, timing parameters, and the dimensions of the separation columns and connecting tubing used to construct the PFM-GC×GC system. Three significant innovations are introduced in this manuscript, which were all uncovered by using the dynamic flow model. A symmetric flow path modulator improves baseline stability, appropriate selection of the flow restrictors in the first dimension column assembly provides a generally more stable and robust system, and these restrictors increase the modulation period flexibility of the PFM-GC×GC system. The flexibility of a PFMGC×GC system resulting from these innovations is illustrated using the same modulation interface to analyze Special Antarctic Blend (SAB) diesel using 3 s and 9 s modulation periods.