Maternal cholestasis during pregnancy programs metabolic disease in offspring
The intrauterine environment is a major contributor to increased rates of metabolic disease in adults. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease of pregnancy that affects 0.5%-2% of pregnant women and is characterized by increased bile acid levels in the maternal serum. The infl...
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American Society for Clinical Investigation
2013
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ftdatacite:10.7892/boris.43271 2023-05-15T17:42:35+02:00 Maternal cholestasis during pregnancy programs metabolic disease in offspring Papacleovoulou, Georgia Abu-Hayyeh, Shadi Owen, Bryn M. Baumann, Marc Marin, Jose J. G. Jarvelin, Marjo-Riitta Williamson, Catherine Nikolova, Vanya Nikolopoulou, Evanthia Vaarasmaki, Marja Briz, Oscar Knisely, A. S. Albrecht, Christiane Huang, Xiao Jansen, Eugene Ovadia, Caroline 2013 application/pdf https://dx.doi.org/10.7892/boris.43271 http://boris.unibe.ch/43271/ en eng American Society for Clinical Investigation info:eu-repo/semantics/openAccess 610 Medicine & health 570 Life sciences; biology CreativeWork article 2013 ftdatacite https://doi.org/10.7892/boris.43271 2021-11-05T12:55:41Z The intrauterine environment is a major contributor to increased rates of metabolic disease in adults. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease of pregnancy that affects 0.5%-2% of pregnant women and is characterized by increased bile acid levels in the maternal serum. The influence of ICP on the metabolic health of offspring is unknown. We analyzed the Northern Finland birth cohort 1985-1986 database and found that 16-year-old children of mothers with ICP had altered lipid profiles. Males had increased BMI, and females exhibited increased waist and hip girth compared with the offspring of uncomplicated pregnancies. We further investigated the effect of maternal cholestasis on the metabolism of adult offspring in the mouse. Females from cholestatic mothers developed a severe obese, diabetic phenotype with hepatosteatosis following a Western diet, whereas matched mice not exposed to cholestasis in utero did not. Female littermates were susceptible to metabolic disease before dietary challenge. Human and mouse studies showed an accumulation of lipids in the fetoplacental unit and increased transplacental cholesterol transport in cholestatic pregnancy. We believe this is the first report showing that cholestatic pregnancy in the absence of altered maternal BMI or diabetes can program metabolic disease in the offspring. Article in Journal/Newspaper Northern Finland DataCite Metadata Store (German National Library of Science and Technology) |
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Open Polar |
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DataCite Metadata Store (German National Library of Science and Technology) |
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language |
English |
topic |
610 Medicine & health 570 Life sciences; biology |
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610 Medicine & health 570 Life sciences; biology Papacleovoulou, Georgia Abu-Hayyeh, Shadi Owen, Bryn M. Baumann, Marc Marin, Jose J. G. Jarvelin, Marjo-Riitta Williamson, Catherine Nikolova, Vanya Nikolopoulou, Evanthia Vaarasmaki, Marja Briz, Oscar Knisely, A. S. Albrecht, Christiane Huang, Xiao Jansen, Eugene Ovadia, Caroline Maternal cholestasis during pregnancy programs metabolic disease in offspring |
topic_facet |
610 Medicine & health 570 Life sciences; biology |
description |
The intrauterine environment is a major contributor to increased rates of metabolic disease in adults. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease of pregnancy that affects 0.5%-2% of pregnant women and is characterized by increased bile acid levels in the maternal serum. The influence of ICP on the metabolic health of offspring is unknown. We analyzed the Northern Finland birth cohort 1985-1986 database and found that 16-year-old children of mothers with ICP had altered lipid profiles. Males had increased BMI, and females exhibited increased waist and hip girth compared with the offspring of uncomplicated pregnancies. We further investigated the effect of maternal cholestasis on the metabolism of adult offspring in the mouse. Females from cholestatic mothers developed a severe obese, diabetic phenotype with hepatosteatosis following a Western diet, whereas matched mice not exposed to cholestasis in utero did not. Female littermates were susceptible to metabolic disease before dietary challenge. Human and mouse studies showed an accumulation of lipids in the fetoplacental unit and increased transplacental cholesterol transport in cholestatic pregnancy. We believe this is the first report showing that cholestatic pregnancy in the absence of altered maternal BMI or diabetes can program metabolic disease in the offspring. |
format |
Article in Journal/Newspaper |
author |
Papacleovoulou, Georgia Abu-Hayyeh, Shadi Owen, Bryn M. Baumann, Marc Marin, Jose J. G. Jarvelin, Marjo-Riitta Williamson, Catherine Nikolova, Vanya Nikolopoulou, Evanthia Vaarasmaki, Marja Briz, Oscar Knisely, A. S. Albrecht, Christiane Huang, Xiao Jansen, Eugene Ovadia, Caroline |
author_facet |
Papacleovoulou, Georgia Abu-Hayyeh, Shadi Owen, Bryn M. Baumann, Marc Marin, Jose J. G. Jarvelin, Marjo-Riitta Williamson, Catherine Nikolova, Vanya Nikolopoulou, Evanthia Vaarasmaki, Marja Briz, Oscar Knisely, A. S. Albrecht, Christiane Huang, Xiao Jansen, Eugene Ovadia, Caroline |
author_sort |
Papacleovoulou, Georgia |
title |
Maternal cholestasis during pregnancy programs metabolic disease in offspring |
title_short |
Maternal cholestasis during pregnancy programs metabolic disease in offspring |
title_full |
Maternal cholestasis during pregnancy programs metabolic disease in offspring |
title_fullStr |
Maternal cholestasis during pregnancy programs metabolic disease in offspring |
title_full_unstemmed |
Maternal cholestasis during pregnancy programs metabolic disease in offspring |
title_sort |
maternal cholestasis during pregnancy programs metabolic disease in offspring |
publisher |
American Society for Clinical Investigation |
publishDate |
2013 |
url |
https://dx.doi.org/10.7892/boris.43271 http://boris.unibe.ch/43271/ |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.7892/boris.43271 |
_version_ |
1766144467215056896 |