Source data: Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain ...
There are currently no drugs known to rescue the function of Kv1.1 voltage-gated potassium channels carrying loss-of-function sequence variants underlying the inherited movement disorder, Episodic Ataxia 1 (EA1). The Kwakwaka'wakw First Nations of the Pacific Northwest Coast used Fucus gardneri...
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Online Access: | https://dx.doi.org/10.7280/d1569b https://datadryad.org/stash/dataset/doi:10.7280/D1569B |
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ftdatacite:10.7280/d1569b 2024-02-04T10:00:26+01:00 Source data: Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain ... Manville, Rían Abbott, Geoffrey 2023 https://dx.doi.org/10.7280/d1569b https://datadryad.org/stash/dataset/doi:10.7280/D1569B en eng Dryad Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode cc0-1.0 FOS Biological sciences Dataset dataset 2023 ftdatacite https://doi.org/10.7280/d1569b 2024-01-05T04:51:50Z There are currently no drugs known to rescue the function of Kv1.1 voltage-gated potassium channels carrying loss-of-function sequence variants underlying the inherited movement disorder, Episodic Ataxia 1 (EA1). The Kwakwaka'wakw First Nations of the Pacific Northwest Coast used Fucus gardneri (bladderwrack kelp), Physocarpus capitatus (Pacific ninebark) and Urtica dioica (common nettle) to treat locomotor ataxia. Here, extracts of these plants enhanced wild-type Kv1.1 current, especially at subthreshold potentials. Screening of their constituents revealed that gallic acid and tannic acid similarly augmented wild-type Kv1.1 current, with submicromolar potency. Crucially, the extracts and their constituents also enhanced activity of Kv1.1 channels containing EA1-linked sequence variants. Molecular dynamics simulations revealed that gallic acid augments Kv1.1 activity via a previously unreported small-molecule binding site in the extracellular S1-S2 linker. Thus, traditional Native American ataxia treatments ... Dataset First Nations DataCite Metadata Store (German National Library of Science and Technology) Pacific |
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DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
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English |
topic |
FOS Biological sciences |
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FOS Biological sciences Manville, Rían Abbott, Geoffrey Source data: Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain ... |
topic_facet |
FOS Biological sciences |
description |
There are currently no drugs known to rescue the function of Kv1.1 voltage-gated potassium channels carrying loss-of-function sequence variants underlying the inherited movement disorder, Episodic Ataxia 1 (EA1). The Kwakwaka'wakw First Nations of the Pacific Northwest Coast used Fucus gardneri (bladderwrack kelp), Physocarpus capitatus (Pacific ninebark) and Urtica dioica (common nettle) to treat locomotor ataxia. Here, extracts of these plants enhanced wild-type Kv1.1 current, especially at subthreshold potentials. Screening of their constituents revealed that gallic acid and tannic acid similarly augmented wild-type Kv1.1 current, with submicromolar potency. Crucially, the extracts and their constituents also enhanced activity of Kv1.1 channels containing EA1-linked sequence variants. Molecular dynamics simulations revealed that gallic acid augments Kv1.1 activity via a previously unreported small-molecule binding site in the extracellular S1-S2 linker. Thus, traditional Native American ataxia treatments ... |
format |
Dataset |
author |
Manville, Rían Abbott, Geoffrey |
author_facet |
Manville, Rían Abbott, Geoffrey |
author_sort |
Manville, Rían |
title |
Source data: Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain ... |
title_short |
Source data: Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain ... |
title_full |
Source data: Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain ... |
title_fullStr |
Source data: Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain ... |
title_full_unstemmed |
Source data: Native American ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain ... |
title_sort |
source data: native american ataxia medicines rescue ataxia-linked mutant potassium channel activity via binding to the voltage sensing domain ... |
publisher |
Dryad |
publishDate |
2023 |
url |
https://dx.doi.org/10.7280/d1569b https://datadryad.org/stash/dataset/doi:10.7280/D1569B |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
First Nations |
genre_facet |
First Nations |
op_rights |
Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode cc0-1.0 |
op_doi |
https://doi.org/10.7280/d1569b |
_version_ |
1789965707664949248 |