Cancer incidence and mortality after a first-ever venous thrombosis: a cohort study in northern Sweden ...

• Main Authors: Hägg, Lovisa, Ehrs, Felicia, Lind, Marcus, Johansson, Magdalena
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: figshare 2024
• Subjects: Medicine; Biotechnology; Environmental Sciences not elsewhere classified; Biological Sciences not elsewhere classified; Cancer; Science Policy; Hematology; Northern Sweden
• Online Access: https://dx.doi.org/10.6084/m9.figshare.c.7413670.v1; https://springernature.figshare.com/collections/Cancer_incidence_and_mortality_after_a_first-ever_venous_thrombosis_a_cohort_study_in_northern_Sweden/7413670/1

Abstract Background Venous thromboembolism (VTE) has a high mortality rate and can be the first manifestation of cancer. We investigated the incidence of cancer after first-ever VTE and the association between VTE and all-cause mortality. Methods A Swedish cohort study that included 105,997 participants without previous cancer who underwent a health examination from 1985–2014 was conducted. Manually validated first-ever VTE events, incident cancer according to the Swedish cancer registry, and mortality were registered. Participants were followed until September 5, 2014. Results The mean age at inclusion was 46.2 years, and 50.3% of participants were female. We identified 1303 persons in the cohort with a VTE and no previous cancer. Among these, 179 (13.7%) were diagnosed with cancer after the VTE event, resulting in a cancer incidence of 26.4 (95% CI 22.8–30.6) cases per 1000 person-years. The incidence was highest during the first 6 months after the VTE. In the study population, VTE was associated with an ...