Analysis of admixed Greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between Inuit and Europeans ...
Abstract Background Disease prevalence and mean phenotype values differ between many populations, including Inuit and Europeans. Whether these differences are partly explained by genetic differences or solely due to differences in environmental exposures is still unknown, because estimates of the ge...
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ftdatacite:10.6084/m9.figshare.c.7248797.v1 2024-09-15T18:10:14+00:00 Analysis of admixed Greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between Inuit and Europeans ... Lin, Long Andersen, Mette K. Stæger, Frederik Filip Li, Zilong Hanghøj, Kristian Linneberg, Allan Grarup, Niels Jørgensen, Marit Eika Hansen, Torben Moltke, Ida Albrechtsen, Anders 2024 https://dx.doi.org/10.6084/m9.figshare.c.7248797.v1 https://springernature.figshare.com/collections/Analysis_of_admixed_Greenlandic_siblings_shows_that_the_mean_genotypic_values_for_metabolic_phenotypes_differ_between_Inuit_and_Europeans/7248797/1 unknown figshare https://dx.doi.org/10.6084/m9.figshare.c.7248797 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 Genetics FOS: Biological sciences Evolutionary Biology Environmental Sciences not elsewhere classified Ecology Biological Sciences not elsewhere classified Collection article 2024 ftdatacite https://doi.org/10.6084/m9.figshare.c.7248797.v110.6084/m9.figshare.c.7248797 2024-09-02T08:51:48Z Abstract Background Disease prevalence and mean phenotype values differ between many populations, including Inuit and Europeans. Whether these differences are partly explained by genetic differences or solely due to differences in environmental exposures is still unknown, because estimates of the genetic contribution to these means, which we will here refer to as mean genotypic values, are easily confounded, and because studies across genetically diverse populations are lacking. Methods Leveraging the unique genetic properties of the small, admixed and historically isolated Greenlandic population, we estimated the differences in mean genotypic value between Inuit and European genetic ancestry using an admixed sibling design. Analyses were performed across 26 metabolic phenotypes, in 1474 admixed sibling pairs present in a cohort of 5996 Greenlanders. Results After FDR correction for multiple testing, we found significantly lower mean genotypic values in Inuit genetic ancestry compared to European genetic ... Article in Journal/Newspaper greenlander* greenlandic inuit DataCite |
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Genetics FOS: Biological sciences Evolutionary Biology Environmental Sciences not elsewhere classified Ecology Biological Sciences not elsewhere classified |
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Genetics FOS: Biological sciences Evolutionary Biology Environmental Sciences not elsewhere classified Ecology Biological Sciences not elsewhere classified Lin, Long Andersen, Mette K. Stæger, Frederik Filip Li, Zilong Hanghøj, Kristian Linneberg, Allan Grarup, Niels Jørgensen, Marit Eika Hansen, Torben Moltke, Ida Albrechtsen, Anders Analysis of admixed Greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between Inuit and Europeans ... |
topic_facet |
Genetics FOS: Biological sciences Evolutionary Biology Environmental Sciences not elsewhere classified Ecology Biological Sciences not elsewhere classified |
description |
Abstract Background Disease prevalence and mean phenotype values differ between many populations, including Inuit and Europeans. Whether these differences are partly explained by genetic differences or solely due to differences in environmental exposures is still unknown, because estimates of the genetic contribution to these means, which we will here refer to as mean genotypic values, are easily confounded, and because studies across genetically diverse populations are lacking. Methods Leveraging the unique genetic properties of the small, admixed and historically isolated Greenlandic population, we estimated the differences in mean genotypic value between Inuit and European genetic ancestry using an admixed sibling design. Analyses were performed across 26 metabolic phenotypes, in 1474 admixed sibling pairs present in a cohort of 5996 Greenlanders. Results After FDR correction for multiple testing, we found significantly lower mean genotypic values in Inuit genetic ancestry compared to European genetic ... |
format |
Article in Journal/Newspaper |
author |
Lin, Long Andersen, Mette K. Stæger, Frederik Filip Li, Zilong Hanghøj, Kristian Linneberg, Allan Grarup, Niels Jørgensen, Marit Eika Hansen, Torben Moltke, Ida Albrechtsen, Anders |
author_facet |
Lin, Long Andersen, Mette K. Stæger, Frederik Filip Li, Zilong Hanghøj, Kristian Linneberg, Allan Grarup, Niels Jørgensen, Marit Eika Hansen, Torben Moltke, Ida Albrechtsen, Anders |
author_sort |
Lin, Long |
title |
Analysis of admixed Greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between Inuit and Europeans ... |
title_short |
Analysis of admixed Greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between Inuit and Europeans ... |
title_full |
Analysis of admixed Greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between Inuit and Europeans ... |
title_fullStr |
Analysis of admixed Greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between Inuit and Europeans ... |
title_full_unstemmed |
Analysis of admixed Greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between Inuit and Europeans ... |
title_sort |
analysis of admixed greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between inuit and europeans ... |
publisher |
figshare |
publishDate |
2024 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.7248797.v1 https://springernature.figshare.com/collections/Analysis_of_admixed_Greenlandic_siblings_shows_that_the_mean_genotypic_values_for_metabolic_phenotypes_differ_between_Inuit_and_Europeans/7248797/1 |
genre |
greenlander* greenlandic inuit |
genre_facet |
greenlander* greenlandic inuit |
op_relation |
https://dx.doi.org/10.6084/m9.figshare.c.7248797 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_doi |
https://doi.org/10.6084/m9.figshare.c.7248797.v110.6084/m9.figshare.c.7248797 |
_version_ |
1810447831506354176 |