An epidemiological and clinicopathological study of type 1 vs. type 2 morphological subtypes of papillary renal cell carcinoma– results from a nation-wide study covering 50 years in Iceland ...

• Main Authors: Runarsson, Thorri Geir, Bergmann, Andreas, Erlingsdottir, Gigja, Petursdottir, Vigdis, Heitmann, Leon Arnar, Johannesson, Aevar, Asbjornsson, Viktor, Axelsson, Tomas, Hilmarsson, Rafn, Gudbjartsson, Tomas
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: figshare 2024
• Subjects: Medicine; Cell Biology; Biotechnology; Biological Sciences not elsewhere classified; Mathematical Sciences not elsewhere classified; Developmental Biology; Cancer; Science Policy; Iceland
• Online Access: https://dx.doi.org/10.6084/m9.figshare.c.7232099; https://springernature.figshare.com/collections/An_epidemiological_and_clinicopathological_study_of_type_1_vs_type_2_morphological_subtypes_of_papillary_renal_cell_carcinoma_results_from_a_nation-wide_study_covering_50_years_in_Iceland/7232099

Abstract Introduction Papillary renal cell carcinoma (pRCC) is the second most common histology of renal cell carcinoma (RCC), accounting for 10–15% of cases. Traditionally, pRCC is divided into type 1 and type 2, although this division is currently debated as a prognostic factor of survival. Our aim was to investigate the epidemiology and survival of the pRCC subtypes in a whole nation cohort of patients during a 50-year period. Materials and methods A Population based retrospective study including consecutive cases of RCC in Iceland from 1971–2020. Comparisons were made between histological classifications of RCC, with emphasis on pRCC subtypes (type 1 vs. 2) for outcome estimation. Changes in RCC incidence were analyzed in 5-year intervals after age standardization. The Kaplan–Meier method and Cox regression were used for outcome analysis. Results A total of 1.725 cases were identified, with 74.4%, 2.1% and 9.2% having clear cell (ccRCC), chromophobe (chRCC), and pRCC, respectively. The age standardized ...