A network pharmacology approach to decipher the mechanism of total flavonoids from Dracocephalum Moldavica L. in the treatment of cardiovascular diseases ...

• Main Authors: Zheng, Rui-fang, Kader, Kaderyea, Liu, Di-wei, Su, Wen-ling, Xu, Lei, Jin, Yuan-yuan, Xing, Jian-guo
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: figshare 2024
• Subjects: Biochemistry; Medicine; Cell Biology; Molecular Biology; Pharmacology; Chemical Sciences not elsewhere classified; Biological Sciences not elsewhere classified; Information Systems not elsewhere classified; DML
• Online Access: https://dx.doi.org/10.6084/m9.figshare.c.7005115; https://springernature.figshare.com/collections/A_network_pharmacology_approach_to_decipher_the_mechanism_of_total_flavonoids_from_Dracocephalum_Moldavica_L_in_the_treatment_of_cardiovascular_diseases/7005115

Abstract Aim of the study Cardiovascular disease (CVD) seriously endangers human health and is characterized by high mortality and disability. The effectiveness of Dracocephalum moldavica L. in the treatment of CVD has been proven by clinical practice. However, the mechanism by which DML can treat CVD has not been systematically determined. Materials and methods The active compounds in DML were screened by literature mining and pharmacokinetic analysis. Cytoscape software was used to construct the target-disease interaction network of DML in the treatment of CVD. Gene ontology and signalling pathway enrichment analyses were performed. The key target pathway network of DML compounds was constructed and verified by pharmacological experiments in vitro. A hydrogen glucose deprivation/reoxygenation model was established in H9c2 cells using hypoxia and glucose deprivation for 9 h combined with reoxygenation for 2 h. The model simulated myocardial ischaemic reperfusion injury to investigate the effects of total ...