Genome-wide allele frequency studies in Pacific oyster families identify candidate genes for tolerance to ostreid herpesvirus 1 (OsHV-1) ...

• Main Authors: Divilov, Konstantin, Merz, Noah, Schoolfield, Blaine, Green, Timothy J., Langdon, Chris
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: figshare 2023
• Subjects: Genetics; FOS Biological sciences; Pacific; Crassostrea gigas; Pacific oyster
• Online Access: https://dx.doi.org/10.6084/m9.figshare.c.6894257.v1; https://springernature.figshare.com/collections/Genome-wide_allele_frequency_studies_in_Pacific_oyster_families_identify_candidate_genes_for_tolerance_to_ostreid_herpesvirus_1_OsHV-1_/6894257/1

Abstract Background Host genetics influences the development of infectious diseases in many agricultural animal species. Identifying genes associated with disease development has the potential to make selective breeding for disease tolerance more likely to succeed through the selection of different genes in diverse signaling pathways. In this study, four families of Pacific oysters (Crassostrea gigas) were identified to be segregating for a quantitative trait locus (QTL) on chromosome 8. This QTL was previously found to be associated with basal antiviral gene expression and survival to ostreid herpesvirus 1 (OsHV-1) mortality events in Tomales Bay, California. Individuals from these four families were phenotyped and genotyped in an attempt to find candidate genes associated with the QTL on chromosome 8. Results Genome-wide allele frequencies of oysters from each family prior to being planting in Tomales Bay were compared with the allele frequencies of oysters from respective families that survived an OsHV-1 ...