Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer’s mouse models ...

• Main Authors: Petrisko, Tiffany J., Gargus, Matthew, Chu, Shu-Hui, Selvan, Purnika, Whiteson, Katrine L., Tenner, Andrea J.
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: figshare 2023
• Subjects: Biochemistry; Microbiology; FOS: Biological sciences; Cell Biology; Neuroscience; Biological Sciences not elsewhere classified; Mental Health; Arctic
• Online Access: https://dx.doi.org/10.6084/m9.figshare.c.6842839.v1; https://springernature.figshare.com/collections/Influence_of_complement_protein_C1q_or_complement_receptor_C5aR1_on_gut_microbiota_composition_in_wildtype_and_Alzheimer_s_mouse_models/6842839/1

Abstract The contribution of the gut microbiome to neuroinflammation, cognition, and Alzheimer’s disease progression has been highlighted over the past few years. Additionally, inhibition of various components of the complement system has repeatedly been demonstrated to reduce neuroinflammation and improve cognitive performance in AD mouse models. Whether the deletion of these complement components is associated with distinct microbiome composition, which could impact neuroinflammation and cognitive performance in mouse models has not yet been examined. Here, we provide a comprehensive analysis of conditional and constitutive knockouts, pharmacological inhibitors, and various housing paradigms for the animal models and wild-type controls at various ages. We aimed to determine the impact of C1q or C5aR1 inhibition on the microbiome in the Arctic and Tg2576 mouse models of AD, which develop amyloid plaques at different ages and locations. Analysis of fecal samples from WT and Arctic mice following global ...