Supplementary material from "Convergent molecular evolution of thermogenesis and circadian rhythm in Arctic ruminants" ...
The muskox and reindeer are the only ruminants that have evolved to survive in harsh Arctic environments. However, the genetic basis of this Arctic adaptation remains largely unclear. Here, we compared a de novo assembled muskox genome with reindeer and other ruminant genomes to identify convergent...
Main Authors: | , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | unknown |
Published: |
The Royal Society
2023
|
Subjects: | |
Online Access: | https://dx.doi.org/10.6084/m9.figshare.c.6644026 https://rs.figshare.com/collections/Supplementary_material_from_Convergent_molecular_evolution_of_thermogenesis_and_circadian_rhythm_in_Arctic_ruminants_/6644026 |
id |
ftdatacite:10.6084/m9.figshare.c.6644026 |
---|---|
record_format |
openpolar |
spelling |
ftdatacite:10.6084/m9.figshare.c.6644026 2024-04-28T08:06:33+00:00 Supplementary material from "Convergent molecular evolution of thermogenesis and circadian rhythm in Arctic ruminants" ... Li, Manman Li, Xinmei Wu, Zhipei Zhang, Guanghui Wang, Nini Dou, Mingle Liu, Shanlin Yang, Chentao Meng, Guanliang Sun, Hailu Hvilsom, Christina Xie, Guoxiang Li, Yang Li, Zhuo hui Wang, Wei Jiang, Yu Heller, Rasmus Wang, Yu 2023 https://dx.doi.org/10.6084/m9.figshare.c.6644026 https://rs.figshare.com/collections/Supplementary_material_from_Convergent_molecular_evolution_of_thermogenesis_and_circadian_rhythm_in_Arctic_ruminants_/6644026 unknown The Royal Society Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 Collection article 2023 ftdatacite https://doi.org/10.6084/m9.figshare.c.6644026 2024-04-02T12:08:10Z The muskox and reindeer are the only ruminants that have evolved to survive in harsh Arctic environments. However, the genetic basis of this Arctic adaptation remains largely unclear. Here, we compared a de novo assembled muskox genome with reindeer and other ruminant genomes to identify convergent amino acid substitutions, rapidly evolving genes and positively selected genes among the two Arctic ruminants. We found these candidate genes were mainly involved in brown adipose tissue (BAT) thermogenesis and circadian rhythm. Furthermore, by integrating transcriptomic data from goat adipose tissues (white and brown), we demonstrated that muskox and reindeer may have evolved modulating mitochondrion, lipid metabolism and angiogenesis pathways to enhance BAT thermogenesis. In addition, results from co-immunoprecipitation experiments prove that convergent amino acid substitution of the angiogenesis-related gene hypoxia-inducible factor 2-alpha ( HIF2A) , resulting in weakening of its interaction with prolyl ... Article in Journal/Newspaper Arctic muskox DataCite Metadata Store (German National Library of Science and Technology) |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
description |
The muskox and reindeer are the only ruminants that have evolved to survive in harsh Arctic environments. However, the genetic basis of this Arctic adaptation remains largely unclear. Here, we compared a de novo assembled muskox genome with reindeer and other ruminant genomes to identify convergent amino acid substitutions, rapidly evolving genes and positively selected genes among the two Arctic ruminants. We found these candidate genes were mainly involved in brown adipose tissue (BAT) thermogenesis and circadian rhythm. Furthermore, by integrating transcriptomic data from goat adipose tissues (white and brown), we demonstrated that muskox and reindeer may have evolved modulating mitochondrion, lipid metabolism and angiogenesis pathways to enhance BAT thermogenesis. In addition, results from co-immunoprecipitation experiments prove that convergent amino acid substitution of the angiogenesis-related gene hypoxia-inducible factor 2-alpha ( HIF2A) , resulting in weakening of its interaction with prolyl ... |
format |
Article in Journal/Newspaper |
author |
Li, Manman Li, Xinmei Wu, Zhipei Zhang, Guanghui Wang, Nini Dou, Mingle Liu, Shanlin Yang, Chentao Meng, Guanliang Sun, Hailu Hvilsom, Christina Xie, Guoxiang Li, Yang Li, Zhuo hui Wang, Wei Jiang, Yu Heller, Rasmus Wang, Yu |
spellingShingle |
Li, Manman Li, Xinmei Wu, Zhipei Zhang, Guanghui Wang, Nini Dou, Mingle Liu, Shanlin Yang, Chentao Meng, Guanliang Sun, Hailu Hvilsom, Christina Xie, Guoxiang Li, Yang Li, Zhuo hui Wang, Wei Jiang, Yu Heller, Rasmus Wang, Yu Supplementary material from "Convergent molecular evolution of thermogenesis and circadian rhythm in Arctic ruminants" ... |
author_facet |
Li, Manman Li, Xinmei Wu, Zhipei Zhang, Guanghui Wang, Nini Dou, Mingle Liu, Shanlin Yang, Chentao Meng, Guanliang Sun, Hailu Hvilsom, Christina Xie, Guoxiang Li, Yang Li, Zhuo hui Wang, Wei Jiang, Yu Heller, Rasmus Wang, Yu |
author_sort |
Li, Manman |
title |
Supplementary material from "Convergent molecular evolution of thermogenesis and circadian rhythm in Arctic ruminants" ... |
title_short |
Supplementary material from "Convergent molecular evolution of thermogenesis and circadian rhythm in Arctic ruminants" ... |
title_full |
Supplementary material from "Convergent molecular evolution of thermogenesis and circadian rhythm in Arctic ruminants" ... |
title_fullStr |
Supplementary material from "Convergent molecular evolution of thermogenesis and circadian rhythm in Arctic ruminants" ... |
title_full_unstemmed |
Supplementary material from "Convergent molecular evolution of thermogenesis and circadian rhythm in Arctic ruminants" ... |
title_sort |
supplementary material from "convergent molecular evolution of thermogenesis and circadian rhythm in arctic ruminants" ... |
publisher |
The Royal Society |
publishDate |
2023 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.6644026 https://rs.figshare.com/collections/Supplementary_material_from_Convergent_molecular_evolution_of_thermogenesis_and_circadian_rhythm_in_Arctic_ruminants_/6644026 |
genre |
Arctic muskox |
genre_facet |
Arctic muskox |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_doi |
https://doi.org/10.6084/m9.figshare.c.6644026 |
_version_ |
1797575995565277184 |