Genetic grouping and geographic distribution of Piscine orthoreovirus-1 (PRV-1) in farmed Atlantic salmon in Norway
Abstract Piscine orthoreovirus-1 (PRV-1) is the causative agent of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar). However, it has been shown that PRV-1 variants differ in their ability to induce HSMI. The objective of this work was to identify the PRV-1 varian...
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ftdatacite:10.6084/m9.figshare.c.5663544 2023-05-15T15:30:55+02:00 Genetic grouping and geographic distribution of Piscine orthoreovirus-1 (PRV-1) in farmed Atlantic salmon in Norway Vatne, Nina A. Stormoen, Marit Lund, Morten Devold, Magnus Rimstad, Espen Wessel, Øystein 2021 https://dx.doi.org/10.6084/m9.figshare.c.5663544 https://springernature.figshare.com/collections/Genetic_grouping_and_geographic_distribution_of_Piscine_orthoreovirus-1_PRV-1_in_farmed_Atlantic_salmon_in_Norway/5663544 unknown figshare https://dx.doi.org/10.1186/s13567-021-01000-1 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Molecular Biology Evolutionary Biology FOS Biological sciences 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Sociology FOS Sociology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified 110309 Infectious Diseases FOS Health sciences 60506 Virology Collection article 2021 ftdatacite https://doi.org/10.6084/m9.figshare.c.5663544 https://doi.org/10.1186/s13567-021-01000-1 2021-11-05T12:55:41Z Abstract Piscine orthoreovirus-1 (PRV-1) is the causative agent of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar). However, it has been shown that PRV-1 variants differ in their ability to induce HSMI. The objective of this work was to identify the PRV-1 variants in Norwegian aquaculture and their geographical distribution. Sequencing and subsequent analysis of the five genomic segments (S1, S4, M2, L1 and L2) putatively linked to virulence, made out the basis of the study. Thirty-seven Norwegian PRV-1 isolates were sequenced, and they grouped into eight genogroups based on combinations of the five analyzed genomic segments. Two groups were defined as high-virulent and two low-virulent, based on comparison with PRV-1 reference isolates with known virulence. The remaining four groups were of unknown virulence. The geographic distribution indicated a higher frequency of the high-virulent isolates in the mid- and northern regions. The present study confirms circulation of both high- and low-virulent isolates of PRV-1 in farmed Atlantic salmon in Norway. To reduce the impact of PRV-1 related disease, detection and differentiation between high- and low-virulent genogroups of PRV-1 could be a targeted approach for reduction of high-virulent variants. Article in Journal/Newspaper Atlantic salmon Salmo salar DataCite Metadata Store (German National Library of Science and Technology) Norway |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
Molecular Biology Evolutionary Biology FOS Biological sciences 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Sociology FOS Sociology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified 110309 Infectious Diseases FOS Health sciences 60506 Virology |
spellingShingle |
Molecular Biology Evolutionary Biology FOS Biological sciences 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Sociology FOS Sociology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified 110309 Infectious Diseases FOS Health sciences 60506 Virology Vatne, Nina A. Stormoen, Marit Lund, Morten Devold, Magnus Rimstad, Espen Wessel, Øystein Genetic grouping and geographic distribution of Piscine orthoreovirus-1 (PRV-1) in farmed Atlantic salmon in Norway |
topic_facet |
Molecular Biology Evolutionary Biology FOS Biological sciences 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Sociology FOS Sociology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified 110309 Infectious Diseases FOS Health sciences 60506 Virology |
description |
Abstract Piscine orthoreovirus-1 (PRV-1) is the causative agent of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar). However, it has been shown that PRV-1 variants differ in their ability to induce HSMI. The objective of this work was to identify the PRV-1 variants in Norwegian aquaculture and their geographical distribution. Sequencing and subsequent analysis of the five genomic segments (S1, S4, M2, L1 and L2) putatively linked to virulence, made out the basis of the study. Thirty-seven Norwegian PRV-1 isolates were sequenced, and they grouped into eight genogroups based on combinations of the five analyzed genomic segments. Two groups were defined as high-virulent and two low-virulent, based on comparison with PRV-1 reference isolates with known virulence. The remaining four groups were of unknown virulence. The geographic distribution indicated a higher frequency of the high-virulent isolates in the mid- and northern regions. The present study confirms circulation of both high- and low-virulent isolates of PRV-1 in farmed Atlantic salmon in Norway. To reduce the impact of PRV-1 related disease, detection and differentiation between high- and low-virulent genogroups of PRV-1 could be a targeted approach for reduction of high-virulent variants. |
format |
Article in Journal/Newspaper |
author |
Vatne, Nina A. Stormoen, Marit Lund, Morten Devold, Magnus Rimstad, Espen Wessel, Øystein |
author_facet |
Vatne, Nina A. Stormoen, Marit Lund, Morten Devold, Magnus Rimstad, Espen Wessel, Øystein |
author_sort |
Vatne, Nina A. |
title |
Genetic grouping and geographic distribution of Piscine orthoreovirus-1 (PRV-1) in farmed Atlantic salmon in Norway |
title_short |
Genetic grouping and geographic distribution of Piscine orthoreovirus-1 (PRV-1) in farmed Atlantic salmon in Norway |
title_full |
Genetic grouping and geographic distribution of Piscine orthoreovirus-1 (PRV-1) in farmed Atlantic salmon in Norway |
title_fullStr |
Genetic grouping and geographic distribution of Piscine orthoreovirus-1 (PRV-1) in farmed Atlantic salmon in Norway |
title_full_unstemmed |
Genetic grouping and geographic distribution of Piscine orthoreovirus-1 (PRV-1) in farmed Atlantic salmon in Norway |
title_sort |
genetic grouping and geographic distribution of piscine orthoreovirus-1 (prv-1) in farmed atlantic salmon in norway |
publisher |
figshare |
publishDate |
2021 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.5663544 https://springernature.figshare.com/collections/Genetic_grouping_and_geographic_distribution_of_Piscine_orthoreovirus-1_PRV-1_in_farmed_Atlantic_salmon_in_Norway/5663544 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
https://dx.doi.org/10.1186/s13567-021-01000-1 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.5663544 https://doi.org/10.1186/s13567-021-01000-1 |
_version_ |
1766361402689191936 |