Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour
Abstract Background Viliuisk encephalomyelitis (VE) is a rare endemic neurodegenerative disease occurring in the Yakut population of Northeastern Siberia. The main clinical features of VE are spasticity, dysarthria, dementia, central paresis and paralysis, and cortical atrophy observed via MRI. Many...
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ftdatacite:10.6084/m9.figshare.c.5214789.v1 2023-05-15T15:10:47+02:00 Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour Kuznetsova, Veronika Tyakht, Alexander Akhmadishina, Lyudmila Odintsova, Vera Klimenko, Natalia Kostryukova, Elena Vakhitova, Maria Grigoryeva, Tatyana Malanin, Sergey Vladimirtsev, Vsevolod Nikitina, Raisa Volok, Viktor Osakovskiy, Vladimir Sivtseva, Tatiana Platonov, Fyodor Alexeev, Dmitry Karganova, Galina 2020 https://dx.doi.org/10.6084/m9.figshare.c.5214789.v1 https://springernature.figshare.com/collections/Gut_microbiome_signature_of_Viliuisk_encephalomyelitis_in_Yakuts_includes_an_increase_in_microbes_linked_to_lean_body_mass_and_eating_behaviour/5214789/1 unknown figshare https://dx.doi.org/10.1186/s13023-020-01612-4 https://dx.doi.org/10.6084/m9.figshare.c.5214789 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Neuroscience Physiology FOS Biological sciences Biotechnology Evolutionary Biology Ecology 69999 Biological Sciences not elsewhere classified Science Policy Computational Biology Collection article 2020 ftdatacite https://doi.org/10.6084/m9.figshare.c.5214789.v1 https://doi.org/10.1186/s13023-020-01612-4 https://doi.org/10.6084/m9.figshare.c.5214789 2021-11-05T12:55:41Z Abstract Background Viliuisk encephalomyelitis (VE) is a rare endemic neurodegenerative disease occurring in the Yakut population of Northeastern Siberia. The main clinical features of VE are spasticity, dysarthria, dementia, central paresis and paralysis, and cortical atrophy observed via MRI. Many hypotheses have been proposed regarding its etiology, including infectious agents, genetics, environmental factors, and immunopathology. Each of these hypotheses has been supported to some extent by epidemiological and experimental data. Nevertheless, none of them has been decisively proven. Gut microbiome is one of the factors that might be involved in VE pathogenesis. Results Here we performed a pilot survey of the stool microbiomes of Yakut subjects with VE (n = 6) and without VE (n = 11). 16S rRNA sequencing showed that in comparison with the control group, the Yakuts with VE had increased proportions of Methanobrevibacter and Christensenella, which are reported to be linked to body mass index, metabolism, dietary habits and potentially to neurodegenerative disorders. The identified associations suggest that the microbiome may be involved in VE. Overall, the Yakut microbiome was quite specific in comparison with other populations, such as metropolitan Russians and native inhabitants of the Canadian Arctic. Conclusions Describing the gut microbiome of indigenous human populations will help to elucidate the impact of dietary and environmental factors on microbial community structure and identify risks linked to the lifestyles of such groups as well as endemic diseases. Article in Journal/Newspaper Arctic Yakut Yakuts Siberia DataCite Metadata Store (German National Library of Science and Technology) Arctic |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
Neuroscience Physiology FOS Biological sciences Biotechnology Evolutionary Biology Ecology 69999 Biological Sciences not elsewhere classified Science Policy Computational Biology |
spellingShingle |
Neuroscience Physiology FOS Biological sciences Biotechnology Evolutionary Biology Ecology 69999 Biological Sciences not elsewhere classified Science Policy Computational Biology Kuznetsova, Veronika Tyakht, Alexander Akhmadishina, Lyudmila Odintsova, Vera Klimenko, Natalia Kostryukova, Elena Vakhitova, Maria Grigoryeva, Tatyana Malanin, Sergey Vladimirtsev, Vsevolod Nikitina, Raisa Volok, Viktor Osakovskiy, Vladimir Sivtseva, Tatiana Platonov, Fyodor Alexeev, Dmitry Karganova, Galina Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
topic_facet |
Neuroscience Physiology FOS Biological sciences Biotechnology Evolutionary Biology Ecology 69999 Biological Sciences not elsewhere classified Science Policy Computational Biology |
description |
Abstract Background Viliuisk encephalomyelitis (VE) is a rare endemic neurodegenerative disease occurring in the Yakut population of Northeastern Siberia. The main clinical features of VE are spasticity, dysarthria, dementia, central paresis and paralysis, and cortical atrophy observed via MRI. Many hypotheses have been proposed regarding its etiology, including infectious agents, genetics, environmental factors, and immunopathology. Each of these hypotheses has been supported to some extent by epidemiological and experimental data. Nevertheless, none of them has been decisively proven. Gut microbiome is one of the factors that might be involved in VE pathogenesis. Results Here we performed a pilot survey of the stool microbiomes of Yakut subjects with VE (n = 6) and without VE (n = 11). 16S rRNA sequencing showed that in comparison with the control group, the Yakuts with VE had increased proportions of Methanobrevibacter and Christensenella, which are reported to be linked to body mass index, metabolism, dietary habits and potentially to neurodegenerative disorders. The identified associations suggest that the microbiome may be involved in VE. Overall, the Yakut microbiome was quite specific in comparison with other populations, such as metropolitan Russians and native inhabitants of the Canadian Arctic. Conclusions Describing the gut microbiome of indigenous human populations will help to elucidate the impact of dietary and environmental factors on microbial community structure and identify risks linked to the lifestyles of such groups as well as endemic diseases. |
format |
Article in Journal/Newspaper |
author |
Kuznetsova, Veronika Tyakht, Alexander Akhmadishina, Lyudmila Odintsova, Vera Klimenko, Natalia Kostryukova, Elena Vakhitova, Maria Grigoryeva, Tatyana Malanin, Sergey Vladimirtsev, Vsevolod Nikitina, Raisa Volok, Viktor Osakovskiy, Vladimir Sivtseva, Tatiana Platonov, Fyodor Alexeev, Dmitry Karganova, Galina |
author_facet |
Kuznetsova, Veronika Tyakht, Alexander Akhmadishina, Lyudmila Odintsova, Vera Klimenko, Natalia Kostryukova, Elena Vakhitova, Maria Grigoryeva, Tatyana Malanin, Sergey Vladimirtsev, Vsevolod Nikitina, Raisa Volok, Viktor Osakovskiy, Vladimir Sivtseva, Tatiana Platonov, Fyodor Alexeev, Dmitry Karganova, Galina |
author_sort |
Kuznetsova, Veronika |
title |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_short |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_full |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_fullStr |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_full_unstemmed |
Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
title_sort |
gut microbiome signature of viliuisk encephalomyelitis in yakuts includes an increase in microbes linked to lean body mass and eating behaviour |
publisher |
figshare |
publishDate |
2020 |
url |
https://dx.doi.org/10.6084/m9.figshare.c.5214789.v1 https://springernature.figshare.com/collections/Gut_microbiome_signature_of_Viliuisk_encephalomyelitis_in_Yakuts_includes_an_increase_in_microbes_linked_to_lean_body_mass_and_eating_behaviour/5214789/1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Yakut Yakuts Siberia |
genre_facet |
Arctic Yakut Yakuts Siberia |
op_relation |
https://dx.doi.org/10.1186/s13023-020-01612-4 https://dx.doi.org/10.6084/m9.figshare.c.5214789 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.c.5214789.v1 https://doi.org/10.1186/s13023-020-01612-4 https://doi.org/10.6084/m9.figshare.c.5214789 |
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